Detailed information of TA system TA100145

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 337985..338655
• Replicon: chromosome
• Accession: NZ_CP027746
• Organism: Pseudomonas chlororaphis subsp. aurantiaca strain DSM 19603

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: C4K17_RS01470
• Protein ID: WP_081362979.1
• Coordinates: 337985..338413 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A3G7DZE9
• Locus tag: C4K17_RS01475
• Protein ID: WP_009046453.1
• Coordinates: 338410..338655 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4K17_RS01455	333104..335362	+	2259	WP_081362982.1	TonB-dependent receptor	-
C4K17_RS01460	335409..336734	+	1326	WP_081362981.1	LLM class flavin-dependent oxidoreductase	-
C4K17_RS01465	336819..337856	+	1038	WP_081362980.1	L-glyceraldehyde 3-phosphate reductase	-
C4K17_RS01470	337985..338413	-	429	WP_081362979.1	type II toxin-antitoxin system VapC family toxin	Toxin
C4K17_RS01475	338410..338655	-	246	WP_009046453.1	plasmid stabilization protein	Antitoxin
C4K17_RS01480	338795..339634	-	840	WP_081362978.1	taurine dioxygenase	-
C4K17_RS01485	339862..340701	-	840	WP_081362977.1	taurine ABC transporter permease TauC	-
C4K17_RS01490	340698..341492	-	795	WP_081362976.1	taurine ABC transporter ATP-binding subunit	-
C4K17_RS01495	341588..342565	-	978	WP_081362975.1	taurine ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15853.36 Da
• Isoelectric Point: 5.4927

>T100145 WP_081362979.1 NZ_CP027746:c338413-337985 [Pseudomonas chlororaphis subsp. aurantiaca]
MIVLDTNVLSELMRPQPDTAVLLWIEAQPVEDLYISAMTMAEILHGIARLPHGKRKQTLHASAVAMFEEDFIDRIVPFGT
QAALYYAHLVSHRERSGQPINLVDAQIAAICRVHDAAIATRNTKDFTDTGLIVINPWLPLEV

Nucleotide

• Length: 429 bp

>T100145 NZ_CP027746:c338413-337985 [Pseudomonas chlororaphis subsp. aurantiaca]
ATGATAGTACTCGACACAAATGTGTTGTCAGAACTGATGCGCCCTCAACCGGATACGGCGGTATTGCTGTGGATCGAAGC
GCAACCCGTCGAGGACCTCTACATCAGCGCTATGACCATGGCCGAGATTCTCCACGGTATCGCGCGCCTGCCCCACGGCA
AGCGCAAACAGACGCTGCATGCATCGGCGGTGGCCATGTTCGAGGAAGACTTCATCGACCGGATCGTGCCCTTCGGAACC
CAAGCAGCTCTTTACTACGCGCATCTGGTTTCGCATCGCGAAAGGTCAGGCCAGCCGATCAATCTGGTGGATGCGCAAAT
TGCAGCGATATGCCGGGTCCACGACGCCGCGATCGCCACTCGTAACACCAAGGATTTCACCGACACCGGGCTGATCGTTA
TCAACCCCTGGCTGCCGCTCGAGGTCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9103.27 Da
• Isoelectric Point: 6.2314

>AT100145 WP_009046453.1 NZ_CP027746:c338655-338410 [Pseudomonas chlororaphis subsp. aurantiaca]
MASLTIRNLDDHIKERLRIEAAHNGHSMEEEARLILRRALSRTADSQGLGSRIRARFAETGGVELELPERTEPARLVDLG
E

Nucleotide

• Length: 246 bp

>AT100145 NZ_CP027746:c338655-338410 [Pseudomonas chlororaphis subsp. aurantiaca]
ATGGCCAGCCTTACGATCCGTAATCTGGACGACCACATCAAAGAACGCCTGCGCATCGAGGCCGCTCACAATGGTCATTC
CATGGAAGAAGAAGCCCGATTGATTTTGCGCCGCGCATTGAGCAGGACAGCTGACAGCCAAGGCCTGGGCAGCCGTATCA
GGGCACGCTTTGCCGAGACCGGCGGAGTAGAGCTGGAGCTGCCTGAACGTACCGAACCGGCACGCTTGGTGGACCTGGGC
GAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3G7DZE9