Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 6046185..6046774 Replicon chromosome
Accession NZ_CP027744
Organism Pseudomonas chlororaphis subsp. aurantiaca strain M71

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag C4K19_RS27370 Protein ID WP_124312233.1
Coordinates 6046475..6046774 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag C4K19_RS27365 Protein ID WP_041987449.1
Coordinates 6046185..6046478 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K19_RS27345 6041726..6042889 - 1164 WP_124312230.1 acyltransferase -
C4K19_RS27350 6043084..6044274 - 1191 WP_124309654.1 serine hydrolase -
C4K19_RS27355 6044401..6045288 + 888 WP_124312231.1 LysR family transcriptional regulator -
C4K19_RS27360 6045660..6046052 + 393 WP_124312232.1 hypothetical protein -
C4K19_RS27365 6046185..6046478 - 294 WP_041987449.1 putative addiction module antidote protein Antitoxin
C4K19_RS27370 6046475..6046774 - 300 WP_124312233.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4K19_RS27375 6046945..6047394 + 450 WP_009051078.1 DUF3828 domain-containing protein -
C4K19_RS27380 6047419..6048429 - 1011 WP_173424526.1 NAD(P)-dependent alcohol dehydrogenase -
C4K19_RS27385 6048487..6048786 - 300 WP_124309658.1 ArsR family transcriptional regulator -
C4K19_RS27390 6048850..6049941 - 1092 WP_124309659.1 nitrite reductase, copper-containing -
C4K19_RS27395 6050167..6050409 + 243 WP_007924102.1 exodeoxyribonuclease VII small subunit -
C4K19_RS27400 6050406..6051293 + 888 WP_038575447.1 (2E,6E)-farnesyl diphosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11237.99 Da        Isoelectric Point: 10.3437

>T100143 WP_124312233.1 NZ_CP027744:c6046774-6046475 [Pseudomonas chlororaphis subsp. aurantiaca]
MIEIKQTATFMEWENRLKDSRARALIAARIFRLANGLAGDVSPVGEGVSELRIHYGPGYRVYFQQCGLQLVILLCGGDKS
RQSRDIELAKQLARRWSRS

Download         Length: 300 bp

>T100143 NZ_CP027744:c6046774-6046475 [Pseudomonas chlororaphis subsp. aurantiaca]
ATGATCGAGATCAAACAGACCGCGACCTTTATGGAGTGGGAAAACAGGCTCAAGGATTCCAGAGCCAGGGCGTTGATCGC
TGCGCGGATTTTTCGCCTGGCCAACGGCCTTGCCGGGGACGTGTCTCCGGTGGGCGAAGGCGTCAGTGAGTTGCGCATCC
ATTACGGGCCGGGCTACCGGGTTTACTTCCAGCAGTGCGGCCTGCAACTCGTCATCCTGTTATGCGGCGGCGACAAGAGT
CGCCAGAGCCGAGATATCGAACTGGCCAAACAGCTGGCCCGTCGTTGGAGCCGATCATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10446.94 Da        Isoelectric Point: 5.6558

>AT100143 WP_041987449.1 NZ_CP027744:c6046478-6046185 [Pseudomonas chlororaphis subsp. aurantiaca]
MNEPLFDYDPATSLRDPQAIALFMADAFETGDAGYIAKALGVVARAKGMTELAHETGLSREQLYRSFSDKGNPTLKTLLA
VMRALGLDMTARVHGAS

Download         Length: 294 bp

>AT100143 NZ_CP027744:c6046478-6046185 [Pseudomonas chlororaphis subsp. aurantiaca]
ATGAACGAACCGCTTTTCGACTATGACCCCGCCACGTCCCTGCGTGACCCGCAGGCCATTGCCCTGTTCATGGCGGACGC
CTTCGAGACCGGCGATGCCGGCTACATCGCCAAAGCCCTGGGCGTGGTGGCGCGGGCCAAGGGCATGACCGAACTGGCCC
ATGAAACCGGGCTGTCCCGCGAGCAGCTGTACCGCTCGTTCAGCGACAAGGGCAACCCGACCCTGAAGACCCTGCTGGCG
GTGATGCGCGCCCTGGGGCTGGACATGACGGCGCGGGTGCATGGGGCGTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References