Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2360964..2361549 Replicon chromosome
Accession NZ_CP027744
Organism Pseudomonas chlororaphis subsp. aurantiaca strain M71

Toxin (Protein)


Gene name PumA Uniprot ID A0A7S5HMS4
Locus tag C4K19_RS10985 Protein ID WP_016705075.1
Coordinates 2361256..2361549 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A3G7ICX6
Locus tag C4K19_RS10980 Protein ID WP_038580367.1
Coordinates 2360964..2361254 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K19_RS10965 2356280..2358796 + 2517 WP_206426775.1 FtsX-like permease family protein -
C4K19_RS10970 2358786..2359862 + 1077 WP_124310795.1 iron ABC transporter permease -
C4K19_RS10975 2359976..2360563 + 588 WP_124308120.1 hypothetical protein -
C4K19_RS10980 2360964..2361254 - 291 WP_038580367.1 putative addiction module antidote protein Antitoxin
C4K19_RS10985 2361256..2361549 - 294 WP_016705075.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4K19_RS10990 2361784..2363178 - 1395 WP_124310796.1 VOC family protein -
C4K19_RS10995 2363440..2364564 + 1125 WP_124310797.1 diguanylate cyclase -
C4K19_RS11000 2364658..2365902 + 1245 WP_124310798.1 M20/M25/M40 family metallo-hydrolase -
C4K19_RS11005 2366149..2366547 + 399 WP_009048182.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-97)

Antitoxin

Uncharacterized protein HI1420

(8-94)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10699.27 Da        Isoelectric Point: 10.0959

>T100141 WP_016705075.1 NZ_CP027744:c2361549-2361256 [Pseudomonas chlororaphis subsp. aurantiaca]
MDYEILQTTVFAQWHTTLRDLRARIAIARRIERASAGNLGDVKNLGGGLSEMRVNTGAGYRLYFTVRGNTLIVLLLGGDK
SSQPADICQARSLAKEF

Download         Length: 294 bp

>T100141 NZ_CP027744:c2361549-2361256 [Pseudomonas chlororaphis subsp. aurantiaca]
ATGGATTACGAGATCCTGCAGACGACCGTCTTTGCCCAATGGCACACCACACTACGGGACCTGCGCGCCAGGATAGCCAT
CGCTCGGCGTATCGAGCGGGCTTCGGCGGGCAACCTGGGCGATGTGAAAAACCTCGGCGGCGGTCTCTCGGAAATGCGCG
TGAACACAGGCGCCGGCTACCGCCTCTATTTCACGGTTCGCGGCAATACCCTCATCGTCCTGCTGCTGGGTGGCGACAAG
TCCAGCCAACCTGCCGATATCTGCCAGGCCCGTTCCCTGGCCAAGGAGTTCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10239.78 Da        Isoelectric Point: 8.0096

>AT100141 WP_038580367.1 NZ_CP027744:c2361254-2360964 [Pseudomonas chlororaphis subsp. aurantiaca]
MSDTLVPFDIAALLDSDQAISEYLSQVLADGDTDELIRALGHVARARGMTQIAKTTGQGRASLYKAFAPGAKPRFDTVVK
VMRALGLQLCTTVSRG

Download         Length: 291 bp

>AT100141 NZ_CP027744:c2361254-2360964 [Pseudomonas chlororaphis subsp. aurantiaca]
ATGTCCGACACACTGGTTCCCTTCGACATCGCCGCCCTGCTCGACAGCGACCAGGCGATCAGCGAATACCTGTCCCAGGT
CCTGGCCGATGGCGATACCGACGAACTGATCCGCGCCCTGGGGCACGTCGCCAGGGCCCGGGGCATGACGCAGATTGCCA
AGACCACCGGCCAGGGCCGGGCCAGCCTCTACAAGGCTTTTGCCCCGGGGGCCAAGCCGCGCTTCGATACCGTGGTCAAG
GTCATGCGCGCGCTGGGCCTGCAGCTGTGCACCACTGTGTCCCGAGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7S5HMS4

Antitoxin

Source ID Structure
AlphaFold DB A0A3G7ICX6

References