Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/- |
| Location | 19192..20524 | Replicon | chromosome |
| Accession | NZ_JMHU01000006 | ||
| Organism | Ligilactobacillus animalis strain 381-IL-28 NODE_6_length_144356_cov_27.537725 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | A0A062X0Y1 |
| Locus tag | Lani381_RS09405 | Protein ID | WP_052006344.1 |
| Coordinates | 19192..19830 (+) | Length | 213 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | A0A062X614 |
| Locus tag | Lani381_RS03055 | Protein ID | WP_035447700.1 |
| Coordinates | 19805..20524 (+) | Length | 240 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| Lani381_RS03025 (Lani381_0622) | 14774..15667 | + | 894 | WP_035447694.1 | hypothetical protein | - |
| Lani381_RS03030 (Lani381_0623) | 15716..16861 | + | 1146 | WP_035447696.1 | hypothetical protein | - |
| Lani381_RS03035 (Lani381_0624) | 17100..17477 | - | 378 | WP_052006343.1 | TetR/AcrR family transcriptional regulator | - |
| Lani381_RS09780 (Lani381_0625) | 17668..17841 | + | 174 | WP_010688191.1 | hypothetical protein | - |
| Lani381_RS03040 (Lani381_0626) | 17942..18382 | + | 441 | WP_010688190.1 | DUF697 domain-containing protein | - |
| Lani381_RS03045 (Lani381_0627) | 18441..19133 | + | 693 | WP_035447698.1 | YjjG family noncanonical pyrimidine nucleotidase | - |
| Lani381_RS09405 (Lani381_0628) | 19192..19830 | + | 639 | WP_052006344.1 | hypothetical protein | Toxin |
| Lani381_RS03055 (Lani381_0629) | 19805..20524 | + | 720 | WP_035447700.1 | DUF4065 domain-containing protein | Antitoxin |
| Lani381_RS03060 (Lani381_0630) | 20799..24419 | + | 3621 | WP_103050411.1 | DNA-directed RNA polymerase subunit beta | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 213 a.a. Molecular weight: 25300.92 Da Isoelectric Point: 6.9699
>T10014 WP_052006344.1 NZ_JMHU01000006:19192-19830 [Ligilactobacillus animalis]
MSDTLVVLSKLIDAISEEYLYFSQKFIQKVNMSKYNLRKLNIGNIMRDDYFLHELIPGYLKFSAILMEKIEYDFLDYLLD
FDFSYRVKSQKTTYDKIRQYSYREKSLGGISVNKSLNDLVGFRIILADIEKNLDGIRDLLTLKCDDKKLFRFIDRDVGGY
HAIHCYFKINNYSFPWELQIWDSANKADNFFAHEEHERKRMVESNASYDRFS
MSDTLVVLSKLIDAISEEYLYFSQKFIQKVNMSKYNLRKLNIGNIMRDDYFLHELIPGYLKFSAILMEKIEYDFLDYLLD
FDFSYRVKSQKTTYDKIRQYSYREKSLGGISVNKSLNDLVGFRIILADIEKNLDGIRDLLTLKCDDKKLFRFIDRDVGGY
HAIHCYFKINNYSFPWELQIWDSANKADNFFAHEEHERKRMVESNASYDRFS
Download Length: 639 bp
>T10014 NZ_JMHU01000006:19192-19830 [Ligilactobacillus animalis]
ATGTCAGATACATTAGTAGTACTATCAAAGTTGATCGATGCTATTTCAGAAGAGTATTTATATTTTTCTCAAAAATTTAT
ACAAAAAGTAAATATGAGCAAATATAATTTACGGAAACTAAATATAGGCAATATTATGCGAGATGATTATTTCTTACATG
AACTTATCCCAGGATATTTAAAATTTTCAGCTATTTTGATGGAAAAGATAGAATATGACTTTCTAGATTATTTATTGGAT
TTTGATTTTAGTTATCGTGTGAAATCCCAAAAGACGACCTATGATAAAATCAGACAGTACTCTTACAGGGAAAAATCTCT
TGGCGGAATTTCTGTAAATAAATCATTAAATGATTTGGTGGGTTTTCGGATCATTTTGGCAGATATTGAAAAAAATCTAG
ACGGAATTAGAGATTTATTAACTTTAAAGTGTGATGATAAGAAGTTATTTCGATTTATTGATCGTGATGTTGGTGGATAT
CATGCAATTCATTGTTATTTCAAGATCAATAACTATAGTTTTCCGTGGGAATTACAGATTTGGGATTCTGCAAACAAAGC
TGATAATTTTTTTGCGCATGAAGAACATGAACGAAAGAGGATGGTGGAAAGTAATGCTTCATATGATCGCTTTAGCTAA
ATGTCAGATACATTAGTAGTACTATCAAAGTTGATCGATGCTATTTCAGAAGAGTATTTATATTTTTCTCAAAAATTTAT
ACAAAAAGTAAATATGAGCAAATATAATTTACGGAAACTAAATATAGGCAATATTATGCGAGATGATTATTTCTTACATG
AACTTATCCCAGGATATTTAAAATTTTCAGCTATTTTGATGGAAAAGATAGAATATGACTTTCTAGATTATTTATTGGAT
TTTGATTTTAGTTATCGTGTGAAATCCCAAAAGACGACCTATGATAAAATCAGACAGTACTCTTACAGGGAAAAATCTCT
TGGCGGAATTTCTGTAAATAAATCATTAAATGATTTGGTGGGTTTTCGGATCATTTTGGCAGATATTGAAAAAAATCTAG
ACGGAATTAGAGATTTATTAACTTTAAAGTGTGATGATAAGAAGTTATTTCGATTTATTGATCGTGATGTTGGTGGATAT
CATGCAATTCATTGTTATTTCAAGATCAATAACTATAGTTTTCCGTGGGAATTACAGATTTGGGATTCTGCAAACAAAGC
TGATAATTTTTTTGCGCATGAAGAACATGAACGAAAGAGGATGGTGGAAAGTAATGCTTCATATGATCGCTTTAGCTAA
Antitoxin
Download Length: 240 a.a. Molecular weight: 27681.57 Da Isoelectric Point: 6.6985
>AT10014 WP_035447700.1 NZ_JMHU01000006:19805-20524 [Ligilactobacillus animalis]
MLHMIALAKQNGIALAYHFAATDKEEFLKKRSELRNISPDFLAGISIHVINSEGTTFADIQSMDPYFSDAIQLDSVSELV
EKVRRLSQLNATDIAAYLVQRYHLNSFLLQKTLYYIYADYLEKYREPPFIADFEAFEHGPVEREVYRKNKYTDELEKSGL
FEGKLAVYPKTAELLLTIKTTVEQCKQQYIAAWDDPGKNLTHRKGTPWSRARARQENLKILDEDICAYHHLERLPTLTK
MLHMIALAKQNGIALAYHFAATDKEEFLKKRSELRNISPDFLAGISIHVINSEGTTFADIQSMDPYFSDAIQLDSVSELV
EKVRRLSQLNATDIAAYLVQRYHLNSFLLQKTLYYIYADYLEKYREPPFIADFEAFEHGPVEREVYRKNKYTDELEKSGL
FEGKLAVYPKTAELLLTIKTTVEQCKQQYIAAWDDPGKNLTHRKGTPWSRARARQENLKILDEDICAYHHLERLPTLTK
Download Length: 720 bp
>AT10014 NZ_JMHU01000006:19805-20524 [Ligilactobacillus animalis]
ATGCTTCATATGATCGCTTTAGCTAAGCAAAATGGAATCGCATTAGCTTATCATTTTGCTGCAACAGACAAAGAAGAATT
TTTAAAAAAAAGAAGTGAATTACGAAATATTTCGCCAGACTTTTTGGCGGGGATCAGTATTCATGTGATAAACAGCGAAG
GAACAACTTTTGCAGATATTCAGAGTATGGATCCATATTTTTCTGATGCAATACAACTAGATAGCGTATCTGAATTAGTT
GAAAAGGTCAGACGGTTGAGTCAATTGAATGCCACTGATATTGCAGCTTATTTAGTACAACGCTACCATTTAAATTCTTT
CTTATTACAAAAGACGCTATATTATATTTATGCTGATTACTTAGAAAAATATCGTGAACCTCCCTTTATCGCTGACTTTG
AAGCATTTGAACATGGACCGGTCGAAAGAGAAGTCTATCGTAAAAATAAATATACTGATGAATTAGAAAAGTCAGGTTTA
TTTGAGGGAAAATTAGCGGTCTACCCAAAAACTGCAGAATTACTTTTGACGATCAAAACAACAGTTGAACAGTGTAAGCA
ACAATATATTGCAGCTTGGGATGATCCGGGGAAAAATTTGACCCATCGAAAAGGGACTCCTTGGAGTCGTGCGCGTGCCA
GGCAAGAAAATTTGAAAATTTTAGATGAAGATATTTGCGCTTATCATCATTTAGAACGTTTGCCGACACTGACGAAATAG
ATGCTTCATATGATCGCTTTAGCTAAGCAAAATGGAATCGCATTAGCTTATCATTTTGCTGCAACAGACAAAGAAGAATT
TTTAAAAAAAAGAAGTGAATTACGAAATATTTCGCCAGACTTTTTGGCGGGGATCAGTATTCATGTGATAAACAGCGAAG
GAACAACTTTTGCAGATATTCAGAGTATGGATCCATATTTTTCTGATGCAATACAACTAGATAGCGTATCTGAATTAGTT
GAAAAGGTCAGACGGTTGAGTCAATTGAATGCCACTGATATTGCAGCTTATTTAGTACAACGCTACCATTTAAATTCTTT
CTTATTACAAAAGACGCTATATTATATTTATGCTGATTACTTAGAAAAATATCGTGAACCTCCCTTTATCGCTGACTTTG
AAGCATTTGAACATGGACCGGTCGAAAGAGAAGTCTATCGTAAAAATAAATATACTGATGAATTAGAAAAGTCAGGTTTA
TTTGAGGGAAAATTAGCGGTCTACCCAAAAACTGCAGAATTACTTTTGACGATCAAAACAACAGTTGAACAGTGTAAGCA
ACAATATATTGCAGCTTGGGATGATCCGGGGAAAAATTTGACCCATCGAAAAGGGACTCCTTGGAGTCGTGCGCGTGCCA
GGCAAGAAAATTTGAAAATTTTAGATGAAGATATTTGCGCTTATCATCATTTAGAACGTTTGCCGACACTGACGAAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A062X0Y1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A062X614 |
References
(1) Tatsuaki Kurata et al. (2022) A hyperpromiscuous antitoxin protein domain for the neutralization of diverse toxin domains. Proceedings of The National Academy of Sciences of The United States of America 119(6):e2102212119. [PubMed:35121656]