Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2389878..2390463 Replicon chromosome
Accession NZ_CP027739
Organism Pseudomonas chlororaphis subsp. piscium strain ToZa7

Toxin (Protein)


Gene name PumA Uniprot ID A0A3G7C0N8
Locus tag C4K30_RS10915 Protein ID WP_025804099.1
Coordinates 2390170..2390463 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A3G7CJP2
Locus tag C4K30_RS10910 Protein ID WP_025804100.1
Coordinates 2389878..2390168 (-) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K30_RS10895 2385203..2387683 + 2481 WP_063430875.1 FtsX-like permease family protein -
C4K30_RS10900 2387673..2388749 + 1077 WP_063429487.1 iron ABC transporter permease -
C4K30_RS10905 2388877..2389464 + 588 WP_063429489.1 hypothetical protein -
C4K30_RS10910 2389878..2390168 - 291 WP_025804100.1 putative addiction module antidote protein Antitoxin
C4K30_RS10915 2390170..2390463 - 294 WP_025804099.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4K30_RS10920 2390699..2392093 - 1395 WP_063429491.1 VOC family protein -
C4K30_RS10925 2392356..2393480 + 1125 WP_051519186.1 diguanylate cyclase -
C4K30_RS10930 2393574..2394818 + 1245 WP_025804096.1 M20/M25/M40 family metallo-hydrolase -
C4K30_RS10935 2395019..2395417 + 399 WP_025804095.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 98 a.a.        Molecular weight: 10837.49 Da        Isoelectric Point: 10.7289

>T100105 WP_025804099.1 NZ_CP027739:c2390463-2390170 [Pseudomonas chlororaphis subsp. piscium]
MEYEILQTTVFAQWHTRLRDLRARIAIARRIERASAGNLGDVKNLGGGLSEMRVNRGAGYRIYFTVRGNTLIVLLLGGDK
STQPADICQARSLAKEF

Download         Length: 294 bp

>T100105 NZ_CP027739:c2390463-2390170 [Pseudomonas chlororaphis subsp. piscium]
ATGGAATACGAGATCCTGCAGACGACCGTCTTTGCCCAATGGCACACCAGACTACGGGACCTGCGCGCCAGGATAGCCAT
CGCTCGGCGTATCGAGCGGGCTTCGGCGGGCAACCTGGGCGATGTGAAAAACCTCGGCGGCGGTCTCTCGGAAATGCGCG
TGAATAGGGGCGCCGGCTACCGCATCTATTTCACGGTTCGCGGCAACACCCTCATCGTCCTGCTGCTGGGCGGCGACAAG
TCCACCCAGCCTGCCGATATCTGCCAGGCCCGTTCCCTGGCCAAGGAGTTCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10249.81 Da        Isoelectric Point: 8.0096

>AT100105 WP_025804100.1 NZ_CP027739:c2390168-2389878 [Pseudomonas chlororaphis subsp. piscium]
MSDTLVPFDIATLLDSDQAISEYLSQVLADGDTDELIRALGHVARARGMTQIAKATGQGRASLYKAFAPGAKPRFDTVVK
VMRALGLQLCTTVPRG

Download         Length: 291 bp

>AT100105 NZ_CP027739:c2390168-2389878 [Pseudomonas chlororaphis subsp. piscium]
ATGTCCGACACACTGGTTCCCTTCGACATCGCCACCCTGCTCGACAGCGACCAGGCGATCAGCGAATACCTGTCCCAGGT
CCTGGCCGATGGCGATACCGATGAACTGATCCGCGCCCTGGGCCATGTCGCCAGGGCCCGGGGCATGACGCAGATTGCCA
AGGCCACCGGCCAGGGCCGGGCCAGCCTCTACAAGGCCTTTGCCCCGGGCGCCAAGCCGCGCTTCGATACCGTGGTCAAG
GTCATGCGCGCGCTGGGCCTGCAGTTGTGCACCACAGTGCCCCGAGGCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3G7C0N8


Antitoxin

Source ID Structure
AlphaFold DB A0A3G7CJP2

References