Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 1567605..1568227 | Replicon | chromosome |
Accession | NZ_CP027738 | ||
Organism | Pseudomonas chlororaphis subsp. piscium strain ChPhzS135 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | A0A2N8AR08 |
Locus tag | C4K31_RS07175 | Protein ID | WP_007929414.1 |
Coordinates | 1568045..1568227 (-) | Length | 61 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A2N8AQX2 |
Locus tag | C4K31_RS07170 | Protein ID | WP_063429381.1 |
Coordinates | 1567605..1568012 (-) | Length | 136 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C4K31_RS07150 | 1562907..1563800 | + | 894 | WP_173678573.1 | LysR family transcriptional regulator | - |
C4K31_RS07155 | 1564036..1565814 | + | 1779 | WP_063428837.1 | GGDEF and EAL domain-containing protein | - |
C4K31_RS07160 | 1565848..1566762 | - | 915 | WP_063428839.1 | SGNH/GDSL hydrolase family protein | - |
C4K31_RS07165 | 1566892..1567359 | - | 468 | WP_063428841.1 | GAF domain-containing protein | - |
C4K31_RS07170 | 1567605..1568012 | - | 408 | WP_063429381.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
C4K31_RS07175 | 1568045..1568227 | - | 183 | WP_007929414.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
C4K31_RS07185 | 1568946..1569830 | - | 885 | WP_009047472.1 | alpha/beta hydrolase | - |
C4K31_RS07190 | 1570182..1570874 | - | 693 | WP_025804997.1 | 16S rRNA pseudouridine(516) synthase | - |
C4K31_RS07195 | 1570908..1571141 | - | 234 | WP_036997815.1 | cysteine-rich CWC family protein | - |
C4K31_RS07200 | 1571134..1572621 | - | 1488 | WP_025804999.1 | sensor domain-containing diguanylate cyclase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6850.15 Da Isoelectric Point: 11.6709
>T100098 WP_007929414.1 NZ_CP027738:c1568227-1568045 [Pseudomonas chlororaphis subsp. piscium]
VNSRYLIGQIVADGWYLVRVRGSHHHFRHPSKPGLVTVPHPKKDLLRKTAISILKQALLM
VNSRYLIGQIVADGWYLVRVRGSHHHFRHPSKPGLVTVPHPKKDLLRKTAISILKQALLM
Download Length: 183 bp
>T100098 NZ_CP027738:c1568227-1568045 [Pseudomonas chlororaphis subsp. piscium]
GTGAACAGTCGGTATTTGATCGGCCAAATCGTCGCAGACGGTTGGTATCTGGTCAGGGTCAGAGGCAGTCACCACCATTT
CAGGCACCCCAGTAAACCGGGGCTGGTGACAGTTCCACATCCCAAAAAGGACCTGCTGAGAAAAACCGCCATCAGCATTC
TGAAACAGGCGCTGCTCATGTGA
GTGAACAGTCGGTATTTGATCGGCCAAATCGTCGCAGACGGTTGGTATCTGGTCAGGGTCAGAGGCAGTCACCACCATTT
CAGGCACCCCAGTAAACCGGGGCTGGTGACAGTTCCACATCCCAAAAAGGACCTGCTGAGAAAAACCGCCATCAGCATTC
TGAAACAGGCGCTGCTCATGTGA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14604.60 Da Isoelectric Point: 4.3638
>AT100098 WP_063429381.1 NZ_CP027738:c1568012-1567605 [Pseudomonas chlororaphis subsp. piscium]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAAIPPANKVTLHAANPQYAGCTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAAIPPANKVTLHAANPQYAGCTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD
Download Length: 408 bp
>AT100098 NZ_CP027738:c1568012-1567605 [Pseudomonas chlororaphis subsp. piscium]
ATGCTTTACCCGATTGCAATTTCAATGGGCGATGACGAACACGCCTGGGGCGTGGAAGTCCCCGACATTCCTGGCTGTTT
CTCGGCCGGCGACGACCTCGACGACGCCATGGCCATGGCCCGCGAAGCCATCGAAGGGCACTTCGAGATTCTCGCCGAAG
ACGGCGCCGCCATCCCACCCGCCAACAAGGTCACCCTGCACGCGGCCAACCCTCAGTATGCAGGCTGCACCTGGGCGCTG
ATCGACATCGATGTCACCAAGTACCTGGGCAAGGCGCAGAAGCTCAACATCACCCTGCCCGGCTACCTGCTGAACCGCAT
CGACGAATACGTGCTGCATCACCCGGAAGCAAAAAGCCGCTCGGGTTTTCTCGCTTCGGCTGCATTGAAGGTATTGCAGC
AGGACTGA
ATGCTTTACCCGATTGCAATTTCAATGGGCGATGACGAACACGCCTGGGGCGTGGAAGTCCCCGACATTCCTGGCTGTTT
CTCGGCCGGCGACGACCTCGACGACGCCATGGCCATGGCCCGCGAAGCCATCGAAGGGCACTTCGAGATTCTCGCCGAAG
ACGGCGCCGCCATCCCACCCGCCAACAAGGTCACCCTGCACGCGGCCAACCCTCAGTATGCAGGCTGCACCTGGGCGCTG
ATCGACATCGATGTCACCAAGTACCTGGGCAAGGCGCAGAAGCTCAACATCACCCTGCCCGGCTACCTGCTGAACCGCAT
CGACGAATACGTGCTGCATCACCCGGAAGCAAAAAGCCGCTCGGGTTTTCTCGCTTCGGCTGCATTGAAGGTATTGCAGC
AGGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2N8AR08 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2N8AQX2 |