Detailed information of TA system TA100096

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 314164..314834
• Replicon: chromosome
• Accession: NZ_CP027738
• Organism: Pseudomonas chlororaphis subsp. piscium strain ChPhzS135

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: C4K31_RS01380
• Protein ID: WP_009046452.1
• Coordinates: 314164..314592 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A3G7DZE9
• Locus tag: C4K31_RS01385
• Protein ID: WP_009046453.1
• Coordinates: 314589..314834 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4K31_RS01350	309374..309853	-	480	WP_063427781.1	DoxX family protein	-
C4K31_RS01355	309910..310650	-	741	WP_063427782.1	SDR family oxidoreductase	-
C4K31_RS01360	310780..311670	+	891	WP_025808442.1	LysR family transcriptional regulator	-
C4K31_RS01365	311795..311977	+	183	WP_009041685.1	type II toxin-antitoxin system HicA family toxin	-
C4K31_RS01370	312007..312408	+	402	WP_025808441.1	type II toxin-antitoxin system HicB family antitoxin	-
C4K31_RS01375	312997..314034	+	1038	WP_063427783.1	L-glyceraldehyde 3-phosphate reductase	-
C4K31_RS01380	314164..314592	-	429	WP_009046452.1	type II toxin-antitoxin system VapC family toxin	Toxin
C4K31_RS01385	314589..314834	-	246	WP_009046453.1	plasmid stabilization protein	Antitoxin
C4K31_RS01390	314974..315813	-	840	WP_106696248.1	taurine dioxygenase	-
C4K31_RS01395	316051..316890	-	840	WP_063427785.1	taurine ABC transporter permease TauC	-
C4K31_RS01400	316887..317681	-	795	WP_063427786.1	taurine ABC transporter ATP-binding subunit	-
C4K31_RS01405	317791..318768	-	978	WP_025808435.1	taurine ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15867.39 Da
• Isoelectric Point: 5.4927

>T100096 WP_009046452.1 NZ_CP027738:c314592-314164 [Pseudomonas chlororaphis subsp. piscium]
MIVLDTNVLSELMRPQPDTAVLLWIEAQPVEDLYISAMTMAEILHGIARLPHGKRKQTLHASALAMFEEDFIDRIVPFGT
QAALYYAHLVSHRERSGQPINLVDAQIAAICRVHDAAIATRNTKDFTDTGLIVINPWLPLEV

Nucleotide

• Length: 429 bp

>T100096 NZ_CP027738:c314592-314164 [Pseudomonas chlororaphis subsp. piscium]
ATGATAGTACTCGACACAAATGTGTTGTCAGAACTGATGCGCCCTCAACCGGATACGGCGGTATTGCTGTGGATCGAAGC
GCAACCCGTCGAGGACCTCTACATCAGCGCTATGACCATGGCCGAGATTCTCCACGGCATCGCGCGCCTGCCTCACGGCA
AGCGCAAACAGACGCTGCATGCATCGGCGCTGGCCATGTTCGAGGAAGACTTCATCGACCGGATCGTGCCCTTCGGAACC
CAAGCGGCTCTTTACTACGCGCATCTGGTCTCGCATCGCGAAAGATCAGGCCAGCCGATCAATCTGGTGGATGCGCAAAT
TGCAGCGATATGCCGGGTCCACGACGCCGCGATCGCCACTCGTAACACCAAGGATTTCACCGACACCGGGCTGATCGTTA
TCAACCCCTGGCTGCCGCTCGAGGTCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9103.27 Da
• Isoelectric Point: 6.2314

>AT100096 WP_009046453.1 NZ_CP027738:c314834-314589 [Pseudomonas chlororaphis subsp. piscium]
MASLTIRNLDDHIKERLRIEAAHNGHSMEEEARLILRRALSRTADSQGLGSRIRARFAETGGVELELPERTEPARLVDLG
E

Nucleotide

• Length: 246 bp

>AT100096 NZ_CP027738:c314834-314589 [Pseudomonas chlororaphis subsp. piscium]
ATGGCCAGCCTTACGATCCGCAATCTGGACGACCACATCAAAGAACGCCTGCGCATCGAGGCCGCTCACAATGGTCATTC
CATGGAAGAAGAAGCCCGATTGATTTTGCGCCGCGCATTGAGCAGGACAGCTGACAGCCAAGGCCTGGGCAGCCGTATCA
GGGCACGCTTTGCCGAGACCGGCGGAGTAGAGTTGGAGCTGCCTGAACGTACCGAACCGGCACGCTTGGTGGACCTGGGC
GAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3G7DZE9