Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2389873..2390458 Replicon chromosome
Accession NZ_CP027737
Organism Pseudomonas chlororaphis subsp. piscium strain PCL1607

Toxin (Protein)


Gene name PumA Uniprot ID A0A3G7C0N8
Locus tag C4K32_RS10905 Protein ID WP_025804099.1
Coordinates 2390165..2390458 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A3G7CJP2
Locus tag C4K32_RS10900 Protein ID WP_025804100.1
Coordinates 2389873..2390163 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K32_RS10885 2385198..2387678 + 2481 WP_124325843.1 FtsX-like permease family protein -
C4K32_RS10890 2387668..2388744 + 1077 WP_124323951.1 iron ABC transporter permease -
C4K32_RS10895 2388872..2389459 + 588 WP_063429489.1 hypothetical protein -
C4K32_RS10900 2389873..2390163 - 291 WP_025804100.1 putative addiction module antidote protein Antitoxin
C4K32_RS10905 2390165..2390458 - 294 WP_025804099.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4K32_RS10910 2390694..2392088 - 1395 WP_124323952.1 VOC family protein -
C4K32_RS10915 2392351..2393475 + 1125 WP_124323953.1 diguanylate cyclase -
C4K32_RS10920 2393569..2394813 + 1245 WP_124348553.1 M20/M25/M40 family metallo-hydrolase -
C4K32_RS10925 2395014..2395412 + 399 WP_025804095.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-96)

Antitoxin

Uncharacterized protein HI1420

(9-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10837.49 Da        Isoelectric Point: 10.7289

>T100093 WP_025804099.1 NZ_CP027737:c2390458-2390165 [Pseudomonas chlororaphis subsp. piscium]
MEYEILQTTVFAQWHTRLRDLRARIAIARRIERASAGNLGDVKNLGGGLSEMRVNRGAGYRIYFTVRGNTLIVLLLGGDK
STQPADICQARSLAKEF

Download         Length: 294 bp

>T100093 NZ_CP027737:c2390458-2390165 [Pseudomonas chlororaphis subsp. piscium]
ATGGAATACGAGATCCTGCAGACGACCGTCTTTGCCCAATGGCACACCAGACTACGGGACCTGCGCGCCAGGATAGCCAT
CGCTCGGCGTATCGAGCGGGCTTCGGCGGGCAACCTGGGCGATGTGAAAAACCTCGGCGGCGGTCTCTCGGAAATGCGCG
TGAATAGGGGCGCCGGCTACCGCATCTATTTCACGGTTCGCGGCAACACCCTCATCGTCCTGCTGCTGGGCGGCGACAAG
TCCACCCAGCCTGCCGATATCTGCCAGGCCCGTTCCCTGGCCAAGGAGTTCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10249.81 Da        Isoelectric Point: 8.0096

>AT100093 WP_025804100.1 NZ_CP027737:c2390163-2389873 [Pseudomonas chlororaphis subsp. piscium]
MSDTLVPFDIATLLDSDQAISEYLSQVLADGDTDELIRALGHVARARGMTQIAKATGQGRASLYKAFAPGAKPRFDTVVK
VMRALGLQLCTTVPRG

Download         Length: 291 bp

>AT100093 NZ_CP027737:c2390163-2389873 [Pseudomonas chlororaphis subsp. piscium]
ATGTCCGACACACTGGTTCCCTTCGACATCGCCACCCTGCTCGACAGCGACCAGGCGATCAGCGAATACCTGTCCCAGGT
CCTGGCCGATGGCGATACCGATGAACTGATCCGCGCCCTGGGCCATGTCGCCAGGGCCCGGGGCATGACGCAGATTGCCA
AGGCCACCGGCCAGGGCCGGGCCAGCCTCTACAAGGCCTTTGCCCCGGGCGCCAAGCCGCGCTTCGATACCGTGGTCAAG
GTCATGCGCGCGCTGGGCCTGCAGTTGTGCACCACAGTGCCCCGAGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G7C0N8

Antitoxin

Source ID Structure
AlphaFold DB A0A3G7CJP2

References