Detailed information of TA system TA100091

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 314139..314809
• Replicon: chromosome
• Accession: NZ_CP027737
• Organism: Pseudomonas chlororaphis subsp. piscium strain PCL1607

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: C4K32_RS01380
• Protein ID: WP_124323278.1
• Coordinates: 314139..314567 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A3G7DZE9
• Locus tag: C4K32_RS01385
• Protein ID: WP_009046453.1
• Coordinates: 314564..314809 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4K32_RS01350	309347..309826	-	480	WP_063427781.1	DoxX family protein	-
C4K32_RS01355	309883..310623	-	741	WP_063427782.1	SDR family oxidoreductase	-
C4K32_RS01360	310753..311643	+	891	WP_124323276.1	LysR family transcriptional regulator	-
C4K32_RS01365	311768..311950	+	183	WP_009041685.1	type II toxin-antitoxin system HicA family toxin	-
C4K32_RS01370	311980..312381	+	402	WP_025808441.1	type II toxin-antitoxin system HicB family antitoxin	-
C4K32_RS01375	312972..314009	+	1038	WP_124348441.1	L-glyceraldehyde 3-phosphate reductase	-
C4K32_RS01380	314139..314567	-	429	WP_124323278.1	type II toxin-antitoxin system VapC family toxin	Toxin
C4K32_RS01385	314564..314809	-	246	WP_009046453.1	plasmid stabilization protein	Antitoxin
C4K32_RS01390	314949..315788	-	840	WP_124323279.1	taurine dioxygenase	-
C4K32_RS01395	316026..316865	-	840	WP_124323280.1	taurine ABC transporter permease TauC	-
C4K32_RS01400	316862..317656	-	795	WP_023970012.1	taurine ABC transporter ATP-binding subunit	-
C4K32_RS01405	317767..318744	-	978	WP_124323281.1	taurine ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15862.37 Da
• Isoelectric Point: 5.4577

>T100091 WP_124323278.1 NZ_CP027737:c314567-314139 [Pseudomonas chlororaphis subsp. piscium]
MIVLDTNVLSELMHPQPDTAVLLWIEAQPVEDLYISAMTMAEILHGIARLPHGKRKQTLHASALAMFEEDFIDRIVPFGT
QAALYYAHLVSHRERSGQPINLVDAQIAAICRVHDAAIATRNTKDFTDTGLIVINPWLPLEI

Nucleotide

• Length: 429 bp

>T100091 NZ_CP027737:c314567-314139 [Pseudomonas chlororaphis subsp. piscium]
ATGATAGTACTCGACACAAATGTGTTGTCAGAACTGATGCACCCTCAACCGGATACGGCGGTATTGCTGTGGATCGAAGC
GCAACCCGTCGAGGACCTCTACATCAGCGCCATGACCATGGCCGAGATTCTCCACGGTATCGCGCGTCTGCCCCACGGCA
AGCGCAAACAGACGCTGCATGCATCGGCGCTGGCCATGTTCGAGGAAGACTTCATCGACCGGATCGTGCCCTTCGGAACC
CAGGCGGCTCTTTACTACGCGCATCTGGTCTCGCATCGCGAAAGATCAGGCCAGCCGATCAACCTGGTGGACGCGCAGAT
TGCAGCGATATGCCGGGTCCATGACGCCGCGATTGCCACCCGCAACACCAAGGATTTCACCGACACTGGGCTGATCGTTA
TCAACCCCTGGCTACCGCTGGAAATCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9103.27 Da
• Isoelectric Point: 6.2314

>AT100091 WP_009046453.1 NZ_CP027737:c314809-314564 [Pseudomonas chlororaphis subsp. piscium]
MASLTIRNLDDHIKERLRIEAAHNGHSMEEEARLILRRALSRTADSQGLGSRIRARFAETGGVELELPERTEPARLVDLG
E

Nucleotide

• Length: 246 bp

>AT100091 NZ_CP027737:c314809-314564 [Pseudomonas chlororaphis subsp. piscium]
ATGGCCAGCCTTACGATCCGCAATCTGGACGACCACATCAAAGAACGCCTGCGCATCGAGGCCGCTCACAATGGTCATTC
CATGGAAGAAGAAGCCCGATTGATTTTGCGCCGCGCATTGAGCAGGACAGCTGACAGCCAAGGCCTGGGCAGCCGTATCA
GGGCACGCTTTGCCGAGACCGGCGGAGTAGAGTTGGAGCTGCCTGAACGTACCGAACCGGCACGCTTGGTGGACCTGGGC
GAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3G7DZE9