Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2315694..2316313 Replicon chromosome
Accession NZ_CP027736
Organism Pseudomonas chlororaphis subsp. piscium strain PCL1391

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G7DMG3
Locus tag C4K33_RS10495 Protein ID WP_009048155.1
Coordinates 2316131..2316313 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A285IZU0
Locus tag C4K33_RS10490 Protein ID WP_007923747.1
Coordinates 2315694..2316095 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K33_RS10470 2311808..2313697 + 1890 WP_063429462.1 PAS domain S-box protein -
C4K33_RS10475 2313694..2314329 + 636 WP_063429464.1 response regulator transcription factor -
C4K33_RS10480 2314423..2315187 + 765 WP_063429471.1 hypothetical protein -
C4K33_RS10490 2315694..2316095 - 402 WP_007923747.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C4K33_RS10495 2316131..2316313 - 183 WP_009048155.1 type II toxin-antitoxin system HicA family toxin Toxin
C4K33_RS10500 2316605..2316886 - 282 WP_063429473.1 hypothetical protein -
C4K33_RS10505 2317242..2317598 - 357 WP_063429475.1 hypothetical protein -
C4K33_RS10510 2317583..2318365 - 783 WP_063429476.1 hypothetical protein -
C4K33_RS10515 2318376..2318921 - 546 WP_081251618.1 PAAR domain-containing protein -
C4K33_RS10520 2319234..2321063 + 1830 WP_081251635.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6799.98 Da        Isoelectric Point: 10.9678

>T100087 WP_009048155.1 NZ_CP027736:c2316313-2316131 [Pseudomonas chlororaphis subsp. piscium]
VQSRQLIKELEAAGWVLERVTGSHHLFKHPYRPETVPVPHPKKDLPRGTVRAIQKLAGLI

Download         Length: 183 bp

>T100087 NZ_CP027736:c2316313-2316131 [Pseudomonas chlororaphis subsp. piscium]
GTGCAAAGCAGACAGTTGATCAAGGAGCTTGAAGCCGCAGGCTGGGTGCTGGAGCGCGTTACCGGTAGCCATCATCTGTT
CAAGCATCCCTACCGGCCCGAGACCGTTCCGGTGCCTCACCCGAAGAAAGATCTGCCACGGGGGACGGTCAGGGCCATCC
AGAAACTGGCCGGGCTGATATAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14579.54 Da        Isoelectric Point: 4.6017

>AT100087 WP_007923747.1 NZ_CP027736:c2316095-2315694 [Pseudomonas chlororaphis subsp. piscium]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIAHVMLEELAREGQAIPLPSPTGTHRANPDFEGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Download         Length: 402 bp

>AT100087 NZ_CP027736:c2316095-2315694 [Pseudomonas chlororaphis subsp. piscium]
GTGCAATATCCCATCTGCATCGAGTGGGGCGACGAGCACACTGCTACCGGCATCCAGATTCCTGACATTCCGGGCGCGGT
AACCGCCGGCGACACCTTCGAGGCCGCGTATAGCGCCGCCATCGAGATCGCCCACGTCATGCTCGAAGAGCTGGCCCGTG
AGGGGCAAGCCATTCCCCTGCCCTCGCCCACCGGCACGCACCGCGCCAACCCCGACTTCGAGGGGATGGGCTGGGGCATG
CTGGATATCGATATCACGCCTTACCTGGGCAAAACCGAGAAGGTCAATGTGACCCTGCCGGGTTACGTGATTCAACGAAT
CGACCGCTTTGTGCGGGAGCACAACATCAAGAGCCGATCGTCATTCCTGGCGGATGCGGCGATGGAAAAGCTGGGGCGTT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G7DMG3

Antitoxin

Source ID Structure
AlphaFold DB A0A285IZU0

References