Detailed information of TA system TA100072

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1831448..1832052
• Replicon: chromosome
• Accession: NZ_CP027734
• Organism: Pseudomonas sp. R1-43-08

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A3G8C3H2
• Locus tag: C4J87_RS08410
• Protein ID: WP_057722727.1
• Coordinates: 1831448..1831636 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C4J87_RS08415
• Protein ID: WP_048729935.1
• Coordinates: 1831648..1832052 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4J87_RS08385	1827658..1828194	+	537	WP_124366412.1	DsbE family thiol:disulfide interchange protein	-
C4J87_RS08390	1828191..1828664	+	474	WP_124366413.1	cytochrome c-type biogenesis protein CcmH	-
C4J87_RS08395	1828657..1829841	+	1185	WP_124366414.1	c-type cytochrome biogenesis protein CcmI	-
C4J87_RS08400	1829857..1830252	+	396	WP_124366415.1	hypothetical protein	-
C4J87_RS08405	1830701..1831267	+	567	WP_124366416.1	phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN	-
C4J87_RS08410	1831448..1831636	+	189	WP_057722727.1	type II toxin-antitoxin system HicA family toxin	Toxin
C4J87_RS08415	1831648..1832052	+	405	WP_048729935.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C4J87_RS08420	1832049..1833244	-	1196	Protein_1621	MFS transporter	-
C4J87_RS08425	1833469..1834473	-	1005	WP_124366417.1	sulfate ABC transporter substrate-binding protein	-
C4J87_RS08430	1834570..1835394	-	825	WP_124361959.1	ion transporter	-
C4J87_RS08435	1835426..1836301	-	876	WP_124366418.1	urea transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7204.45 Da
• Isoelectric Point: 11.2000

>T100072 WP_057722727.1 NZ_CP027734:1831448-1831636 [Pseudomonas sp. R1-43-08]
VQSRLLIKELLEAGWVLDRVTGSHHIFTHRYNPYTIPVPHPKKDLPLGTVRSIRKRAGLFQF

Nucleotide

• Length: 189 bp

>T100072 NZ_CP027734:1831448-1831636 [Pseudomonas sp. R1-43-08]
GTGCAAAGCAGGCTATTGATCAAGGAATTGCTGGAAGCGGGTTGGGTGCTGGATCGCGTCACCGGCAGCCATCACATTTT
TACCCACCGCTATAACCCGTACACGATTCCGGTGCCTCATCCGAAGAAGGATCTTCCCTTGGGCACCGTCAGAAGCATCA
GGAAACGCGCCGGGCTGTTTCAGTTTTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14703.69 Da
• Isoelectric Point: 4.6000

>AT100072 WP_048729935.1 NZ_CP027734:1831648-1832052 [Pseudomonas sp. R1-43-08]
MQYPICIEWGDDFTATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHIMLQEIAAEGGVIPMPTSVANHHAHEDYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRS

Nucleotide

• Length: 405 bp

>AT100072 NZ_CP027734:1831648-1832052 [Pseudomonas sp. R1-43-08]
ATGCAATACCCAATCTGTATCGAATGGGGCGATGACTTCACCGCCACCGGTATCCAGATCCCCGATATTCCGGGTGCTGT
CACCGCCGGGGACAGTTTTGAAGAGGCGTACAACGCGGCCGTGGAGGTTGCACACATCATGCTGCAGGAGATCGCCGCCG
AGGGCGGAGTGATTCCGATGCCAACCTCAGTCGCCAATCATCACGCCCATGAAGACTACGCCGGCATGGGCTGGGGCATG
TTGGAGCTGGACATCTCGCCCTATCTGGGCAAGACCGAGAAGGTCAACGTGACCTTGCCCGGCTATGTCATCCAACGCAT
CGACCGTTACGTGCGCGAGCATAAAGTCAAAAGCCGCTCGTCATTTCTGGCGGACGCGGCTTTGGAGAAGTTGGTGCGGT
CTTAA

Structures

Toxin

• AlphaFold DB: A0A3G8C3H2