Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1858513..1859102 Replicon chromosome
Accession NZ_CP027732
Organism Pseudomonas sp. R4-35-07

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C4J89_RS08580 Protein ID WP_124361955.1
Coordinates 1858513..1858686 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C4J89_RS08585 Protein ID WP_048729935.1
Coordinates 1858698..1859102 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4J89_RS08550 1854236..1854772 + 537 WP_124414238.1 DsbE family thiol:disulfide interchange protein -
C4J89_RS08555 1854769..1855242 + 474 WP_124361950.1 cytochrome c-type biogenesis protein CcmH -
C4J89_RS08560 1855235..1856419 + 1185 WP_124414239.1 c-type cytochrome biogenesis protein CcmI -
C4J89_RS08565 1856435..1856830 + 396 WP_124361952.1 hypothetical protein -
C4J89_RS08570 1856998..1857273 - 276 WP_124361953.1 DUF3077 domain-containing protein -
C4J89_RS08575 1857751..1858317 + 567 WP_124414240.1 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN -
C4J89_RS08580 1858513..1858686 + 174 WP_124361955.1 type II toxin-antitoxin system HicA family toxin Toxin
C4J89_RS08585 1858698..1859102 + 405 WP_048729935.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C4J89_RS08590 1859099..1860295 - 1197 WP_124414241.1 MFS transporter -
C4J89_RS08595 1860536..1861540 - 1005 WP_124414242.1 sulfate ABC transporter substrate-binding protein -
C4J89_RS08600 1861637..1862461 - 825 WP_124414243.1 ion transporter -
C4J89_RS08605 1862493..1863368 - 876 WP_124414244.1 urea transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(1-54)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6653.77 Da        Isoelectric Point: 10.8750

>T100058 WP_124361955.1 NZ_CP027732:1858513-1858686 [Pseudomonas sp. R4-35-07]
MIKELQEAGWVLDRVTGSHHIFTHRYNPYTIPVPHPKKDLPLGTVRSIRKRAGLFQF

Download         Length: 174 bp

>T100058 NZ_CP027732:1858513-1858686 [Pseudomonas sp. R4-35-07]
TTGATCAAAGAGCTGCAAGAGGCGGGTTGGGTGCTGGATCGTGTCACCGGCAGCCATCACATTTTTACCCACCGCTATAA
CCCGTACACGATCCCGGTGCCTCATCCGAAGAAAGATCTTCCCTTGGGCACCGTCAGAAGCATCAGGAAACGCGCCGGGC
TGTTTCAGTTTTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14703.69 Da        Isoelectric Point: 4.6000

>AT100058 WP_048729935.1 NZ_CP027732:1858698-1859102 [Pseudomonas sp. R4-35-07]
MQYPICIEWGDDFTATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHIMLQEIAAEGGVIPMPTSVANHHAHEDYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRS

Download         Length: 405 bp

>AT100058 NZ_CP027732:1858698-1859102 [Pseudomonas sp. R4-35-07]
ATGCAATACCCAATCTGTATCGAATGGGGCGATGACTTTACCGCCACCGGTATCCAGATCCCCGATATTCCGGGCGCTGT
CACCGCTGGGGACAGTTTTGAAGAGGCGTATAACGCGGCCGTGGAGGTTGCGCACATCATGCTGCAGGAGATCGCCGCCG
AGGGCGGAGTGATTCCGATGCCAACCTCGGTCGCCAATCATCACGCCCATGAAGACTACGCCGGCATGGGCTGGGGCATG
TTGGAGCTGGATATCTCGCCCTATCTGGGCAAGACCGAGAAGGTCAACGTGACCTTGCCCGGCTATGTGATCCAACGCAT
CGACCGTTACGTGCGCGAGCATAAAGTCAAAAGCCGCTCGTCATTTCTGGCGGACGCGGCTTTGGAGAAGTTGGTGCGTT
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References