Detailed information of TA system TA100051

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 1520191..1520704
• Replicon: chromosome
• Accession: NZ_CP027731
• Organism: Pseudomonas sp. R2-60-08W

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C4J90_RS06835
• Protein ID: WP_124361707.1
• Coordinates: 1520191..1520475 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C4J90_RS06840
• Protein ID: WP_124361708.1
• Coordinates: 1520465..1520704 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4J90_RS06815	1516377..1517318	+	942	WP_124419473.1	hydroxymethylglutaryl-CoA lyase	-
C4J90_RS06820	1517377..1518708	+	1332	WP_124361704.1	MFS transporter	-
C4J90_RS06825	1518709..1519197	-	489	WP_124419474.1	DMT family transporter	-
C4J90_RS06830	1519266..1520183	+	918	WP_124419475.1	LysR family transcriptional regulator	-
C4J90_RS06835	1520191..1520475	-	285	WP_124361707.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C4J90_RS06840	1520465..1520704	-	240	WP_124361708.1	ribbon-helix-helix protein, CopG family	Antitoxin
C4J90_RS06845	1520805..1521239	+	435	WP_124419476.1	fosfomycin resistance glutathione transferase	-
C4J90_RS06850	1521269..1521910	+	642	WP_124361710.1	LysE family translocator	-
C4J90_RS06855	1522031..1522558	+	528	WP_124361711.1	DUF4142 domain-containing protein	-
C4J90_RS06860	1522613..1523038	-	426	WP_124361712.1	low affinity iron permease family protein	-
C4J90_RS06865	1523215..1523997	+	783	WP_124419477.1	GNAT family N-acetyltransferase	-
C4J90_RS06870	1523998..1524498	-	501	WP_124419478.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-41)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11014.73 Da
• Isoelectric Point: 10.1506

>T100051 WP_124361707.1 NZ_CP027731:c1520475-1520191 [Pseudomonas sp. R2-60-08W]
MQVEWLRTALRNLDDEAAFIAEENPKAAYEFVQAILAGLEHIAQFPALGKTGRVPGTREWVVPRWPYIVPYRIREGRLQV
MRIFHTRRQPPTSW

Nucleotide

• Length: 285 bp

>T100051 NZ_CP027731:c1520475-1520191 [Pseudomonas sp. R2-60-08W]
ATGCAGGTTGAGTGGCTGAGGACAGCCCTCAGAAACCTGGATGATGAAGCGGCCTTTATTGCTGAAGAAAACCCCAAAGC
CGCCTACGAGTTCGTCCAGGCGATTTTGGCCGGGCTTGAACACATTGCGCAATTTCCCGCGCTGGGAAAAACCGGGCGCG
TCCCAGGGACGCGTGAATGGGTGGTGCCCCGGTGGCCCTACATTGTCCCTTACCGTATTCGTGAAGGGCGACTACAGGTG
ATGCGAATTTTTCATACCCGCCGCCAACCACCGACCTCCTGGTAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8597.72 Da
• Isoelectric Point: 4.7571

>AT100051 WP_124361708.1 NZ_CP027731:c1520704-1520465 [Pseudomonas sp. R2-60-08W]
MSVMSLRIPDDVADTLASLAKATGRSKSFLAVDALREYLTREAWQIEEIQKALKEADAGDFATAAEVKAVADKWRNNAG

Nucleotide

• Length: 240 bp

>AT100051 NZ_CP027731:c1520704-1520465 [Pseudomonas sp. R2-60-08W]
ATGTCTGTTATGTCCCTGCGGATACCGGACGATGTCGCCGATACGCTTGCCAGTCTGGCCAAAGCGACCGGTCGCAGCAA
ATCGTTCCTCGCTGTTGACGCGCTACGTGAATACTTGACGCGTGAAGCATGGCAAATCGAAGAGATTCAAAAGGCGCTGA
AAGAAGCTGATGCGGGGGATTTCGCGACGGCTGCCGAGGTAAAAGCCGTCGCTGACAAATGGCGCAACAATGCAGGTTGA