Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | CapRel-ATcapRel/- |
| Location | 561827..562812 | Replicon | chromosome |
| Accession | NZ_LT717701 | ||
| Organism | Mycobacterium terramassiliense strain AB308 | ||
Toxin (Protein)
| Gene name | capRel | Uniprot ID | - |
| Locus tag | MTAB308_RS17350 | Protein ID | WP_083746574.1 |
| Coordinates | 562081..562812 (-) | Length | 244 a.a. |
Antitoxin (Protein)
| Gene name | ATcapRel | Uniprot ID | - |
| Locus tag | MTAB308_RS17345 | Protein ID | WP_077100730.1 |
| Coordinates | 561827..562084 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MTAB308_RS17305 (B0289_RS17210) | 558022..558327 | + | 306 | WP_077100713.1 | WhiB family transcriptional regulator | - |
| MTAB308_RS28925 (MTAB308_3443) | 558324..558536 | + | 213 | WP_157900961.1 | hypothetical protein | - |
| MTAB308_RS17310 (B0289_RS17215) | 558533..558805 | + | 273 | WP_077100715.1 | hypothetical protein | - |
| MTAB308_RS17315 (B0289_RS17220) | 558874..559125 | + | 252 | WP_245831437.1 | hypothetical protein | - |
| MTAB308_RS17320 (B0289_RS17225) | 559295..559504 | + | 210 | WP_077100719.1 | hypothetical protein | - |
| MTAB308_RS17325 (B0289_RS17230) | 559494..559886 | + | 393 | WP_077100721.1 | helix-turn-helix domain-containing protein | - |
| MTAB308_RS17330 (B0289_RS17235) | 559897..560526 | + | 630 | WP_157900962.1 | hypothetical protein | - |
| MTAB308_RS17335 (B0289_RS17240) | 560541..560966 | + | 426 | WP_157900963.1 | hypothetical protein | - |
| MTAB308_RS17340 (B0289_RS17245) | 561094..561348 | + | 255 | WP_077100726.1 | hypothetical protein | - |
| MTAB308_RS28930 (MTAB308_3451) | 561368..561553 | + | 186 | WP_077100728.1 | hypothetical protein | - |
| MTAB308_RS17345 (B0289_RS17255) | 561827..562084 | - | 258 | WP_077100730.1 | hypothetical protein | Antitoxin |
| MTAB308_RS17350 (B0289_RS17260) | 562081..562812 | - | 732 | WP_083746574.1 | RelA/SpoT domain-containing protein | Toxin |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 552991..575590 | 22599 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 244 a.a. Molecular weight: 26928.94 Da Isoelectric Point: 10.4212
>T10005 WP_083746574.1 NZ_LT717701:c562812-562081 [Mycobacterium terramassiliense]
MAASVPSVSAVNRAGNVLRNLRVTGNRVKVPAAVEITAEQIFAALDTLEAWRAAHARPLGAATMGLRSRVATMGCAHIEV
SQRLKRIPTIIDKLRREPGMNLGRMHDIGGCRAVLQSLDEVQRVQSRYSGDPVTARTKDYVAQPKPDGYRAVHVIVRYQG
RLIEVQLRTQVQHEWAYTVESVTSRFGLDIKAGGGPPPVRDWFAAVSEAMALEEHDQPVGPELLHRVYKLRETAQPYLQG
VRR
MAASVPSVSAVNRAGNVLRNLRVTGNRVKVPAAVEITAEQIFAALDTLEAWRAAHARPLGAATMGLRSRVATMGCAHIEV
SQRLKRIPTIIDKLRREPGMNLGRMHDIGGCRAVLQSLDEVQRVQSRYSGDPVTARTKDYVAQPKPDGYRAVHVIVRYQG
RLIEVQLRTQVQHEWAYTVESVTSRFGLDIKAGGGPPPVRDWFAAVSEAMALEEHDQPVGPELLHRVYKLRETAQPYLQG
VRR
Download Length: 732 bp
>T10005 NZ_LT717701:c562812-562081 [Mycobacterium terramassiliense]
ATGGCTGCGTCTGTGCCGAGCGTGTCCGCAGTGAACCGGGCCGGGAATGTCTTGCGCAATCTGCGAGTAACCGGGAATCG
GGTCAAGGTGCCCGCCGCGGTGGAGATCACGGCCGAACAGATCTTCGCCGCACTGGACACACTGGAGGCGTGGCGCGCCG
CGCACGCTCGTCCTCTCGGGGCCGCAACGATGGGACTGCGGTCACGTGTCGCCACAATGGGCTGCGCTCATATCGAGGTC
TCGCAGCGGTTGAAGCGCATTCCAACGATCATCGACAAACTCAGACGCGAGCCTGGCATGAACCTGGGCCGGATGCACGA
CATCGGCGGATGTCGCGCTGTCCTGCAGAGCCTGGACGAGGTCCAACGCGTCCAATCGAGATATTCCGGCGATCCGGTCA
CTGCCAGAACCAAGGACTACGTTGCCCAGCCAAAACCGGACGGCTATCGCGCAGTGCACGTGATCGTCCGCTATCAGGGG
CGGCTGATCGAAGTCCAGCTTCGAACGCAGGTCCAGCATGAATGGGCCTACACGGTCGAGAGCGTCACATCTCGGTTCGG
GTTGGATATCAAAGCTGGCGGCGGGCCGCCGCCCGTGCGAGACTGGTTCGCGGCAGTGTCAGAGGCGATGGCACTCGAGG
AACACGACCAACCGGTGGGCCCAGAGCTTCTGCACCGGGTATATAAACTGAGAGAGACAGCCCAACCCTACTTGCAAGGA
GTTCGTCGATGA
ATGGCTGCGTCTGTGCCGAGCGTGTCCGCAGTGAACCGGGCCGGGAATGTCTTGCGCAATCTGCGAGTAACCGGGAATCG
GGTCAAGGTGCCCGCCGCGGTGGAGATCACGGCCGAACAGATCTTCGCCGCACTGGACACACTGGAGGCGTGGCGCGCCG
CGCACGCTCGTCCTCTCGGGGCCGCAACGATGGGACTGCGGTCACGTGTCGCCACAATGGGCTGCGCTCATATCGAGGTC
TCGCAGCGGTTGAAGCGCATTCCAACGATCATCGACAAACTCAGACGCGAGCCTGGCATGAACCTGGGCCGGATGCACGA
CATCGGCGGATGTCGCGCTGTCCTGCAGAGCCTGGACGAGGTCCAACGCGTCCAATCGAGATATTCCGGCGATCCGGTCA
CTGCCAGAACCAAGGACTACGTTGCCCAGCCAAAACCGGACGGCTATCGCGCAGTGCACGTGATCGTCCGCTATCAGGGG
CGGCTGATCGAAGTCCAGCTTCGAACGCAGGTCCAGCATGAATGGGCCTACACGGTCGAGAGCGTCACATCTCGGTTCGG
GTTGGATATCAAAGCTGGCGGCGGGCCGCCGCCCGTGCGAGACTGGTTCGCGGCAGTGTCAGAGGCGATGGCACTCGAGG
AACACGACCAACCGGTGGGCCCAGAGCTTCTGCACCGGGTATATAAACTGAGAGAGACAGCCCAACCCTACTTGCAAGGA
GTTCGTCGATGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9448.80 Da Isoelectric Point: 6.4788
>AT10005 WP_077100730.1 NZ_LT717701:c562084-561827 [Mycobacterium terramassiliense]
MTASQLKHFLLVFDHNRAQLIGLKEFGTDAKSAMAEYARLERAHMKESDSIEIVLIGSDSLETVKITHANYFDGTVAVSK
YFAGI
MTASQLKHFLLVFDHNRAQLIGLKEFGTDAKSAMAEYARLERAHMKESDSIEIVLIGSDSLETVKITHANYFDGTVAVSK
YFAGI
Download Length: 258 bp
>AT10005 NZ_LT717701:c562084-561827 [Mycobacterium terramassiliense]
ATGACTGCATCGCAGCTCAAGCACTTCTTGCTCGTATTCGACCACAACCGCGCCCAGCTGATCGGCCTGAAAGAGTTCGG
CACGGACGCCAAGAGTGCGATGGCCGAATACGCCCGGCTAGAACGTGCACACATGAAAGAGTCAGACTCGATCGAGATCG
TCCTGATCGGCTCGGATTCGCTGGAAACCGTGAAGATCACCCACGCGAACTACTTCGACGGCACCGTAGCCGTCTCGAAA
TACTTCGCCGGCATCTGA
ATGACTGCATCGCAGCTCAAGCACTTCTTGCTCGTATTCGACCACAACCGCGCCCAGCTGATCGGCCTGAAAGAGTTCGG
CACGGACGCCAAGAGTGCGATGGCCGAATACGCCCGGCTAGAACGTGCACACATGAAAGAGTCAGACTCGATCGAGATCG
TCCTGATCGGCTCGGATTCGCTGGAAACCGTGAAGATCACCCACGCGAACTACTTCGACGGCACCGTAGCCGTCTCGAAA
TACTTCGCCGGCATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|
References
(1) Tatsuaki Kurata et al. (2021) RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis. Molecular Cell 81(15):3160-3170.e9. [PubMed:34174184]
(2) Steffi Jimmy et al. (2020) A widespread toxin-antitoxin system exploiting growth control via alarmone signaling. Proceedings of The National Academy of Sciences of The United States of America 117(19):10500-10510. [PubMed:32345719]