Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1886677..1887266 Replicon chromosome
Accession NZ_CP027730
Organism Pseudomonas sp. R3-52-08

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C4J91_RS08735 Protein ID WP_124361955.1
Coordinates 1886677..1886850 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C4J91_RS08740 Protein ID WP_124361956.1
Coordinates 1886862..1887266 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4J91_RS08705 1882405..1882941 + 537 WP_124361949.1 DsbE family thiol:disulfide interchange protein -
C4J91_RS08710 1882938..1883411 + 474 WP_124361950.1 cytochrome c-type biogenesis protein CcmH -
C4J91_RS08715 1883404..1884588 + 1185 WP_124361951.1 c-type cytochrome biogenesis protein CcmI -
C4J91_RS08720 1884604..1884999 + 396 WP_124361952.1 hypothetical protein -
C4J91_RS08725 1885167..1885442 - 276 WP_124361953.1 DUF3077 domain-containing protein -
C4J91_RS08730 1885920..1886486 + 567 WP_124361954.1 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN -
C4J91_RS08735 1886677..1886850 + 174 WP_124361955.1 type II toxin-antitoxin system HicA family toxin Toxin
C4J91_RS08740 1886862..1887266 + 405 WP_124361956.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C4J91_RS08745 1887263..1888459 - 1197 WP_124361957.1 MFS transporter -
C4J91_RS08750 1888684..1889688 - 1005 WP_124361958.1 sulfate ABC transporter substrate-binding protein -
C4J91_RS08755 1889785..1890609 - 825 WP_124361959.1 ion transporter -
C4J91_RS08760 1890640..1891515 - 876 WP_124361960.1 urea transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(1-54)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6653.77 Da        Isoelectric Point: 10.8750

>T100046 WP_124361955.1 NZ_CP027730:1886677-1886850 [Pseudomonas sp. R3-52-08]
MIKELQEAGWVLDRVTGSHHIFTHRYNPYTIPVPHPKKDLPLGTVRSIRKRAGLFQF

Download         Length: 174 bp

>T100046 NZ_CP027730:1886677-1886850 [Pseudomonas sp. R3-52-08]
TTGATCAAAGAGCTGCAAGAGGCGGGTTGGGTGCTGGATCGTGTCACCGGCAGCCATCACATTTTTACCCACCGCTATAA
CCCGTACACGATCCCGGTGCCTCATCCGAAGAAAGATCTTCCCTTGGGCACCGTCAGAAGCATCAGGAAACGCGCCGGGC
TGTTTCAGTTTTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14690.69 Da        Isoelectric Point: 4.6000

>AT100046 WP_124361956.1 NZ_CP027730:1886862-1887266 [Pseudomonas sp. R3-52-08]
MQYPICIEWGDDFTATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHIMLQEIAAEGGVIPMPTSVATHHAHEDYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRS

Download         Length: 405 bp

>AT100046 NZ_CP027730:1886862-1887266 [Pseudomonas sp. R3-52-08]
ATGCAATACCCAATCTGCATCGAATGGGGCGATGACTTTACCGCCACCGGTATCCAGATCCCCGATATTCCGGGTGCTGT
CACCGCCGGGGACAGTTTTGAAGAGGCGTATAACGCGGCCGTGGAGGTTGCGCACATCATGCTGCAGGAGATCGCCGCCG
AGGGCGGAGTGATTCCGATGCCAACCTCGGTCGCCACTCATCACGCCCATGAAGACTACGCCGGCATGGGCTGGGGCATG
TTGGAGCTGGATATCTCGCCCTATCTGGGCAAGACCGAGAAGGTCAATGTGACCTTGCCCGGCTATGTCATCCAACGCAT
CGACCGTTACGTGCGCGAGCATAAAGTCAAAAGCCGCTCGTCATTTCTGGCGGACGCGGCTTTGGAGAAGTTGGTGCGTT
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References