Detailed information of TA system TA100041

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3772059..3772623
• Replicon: chromosome
• Accession: NZ_CP027729
• Organism: Pseudomonas sp. R3-18-08

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C4J92_RS17240
• Protein ID: WP_124404707.1
• Coordinates: 3772336..3772623 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C4J92_RS17235
• Protein ID: WP_124367663.1
• Coordinates: 3772059..3772346 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4J92_RS17210	3767260..3768660	+	1401	WP_124404702.1	heavy metal sensor histidine kinase	-
C4J92_RS17215	3768673..3769119	-	447	WP_124404703.1	RcnB family protein	-
C4J92_RS17220	3769184..3769813	-	630	WP_124404704.1	pyroglutamyl-peptidase I	-
C4J92_RS17225	3769821..3770771	-	951	WP_124404705.1	DUF979 domain-containing protein	-
C4J92_RS17230	3770768..3771484	-	717	WP_124404706.1	DUF969 domain-containing protein	-
C4J92_RS17235	3772059..3772346	+	288	WP_124367663.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
C4J92_RS17240	3772336..3772623	+	288	WP_124404707.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C4J92_RS17245	3772861..3773817	+	957	WP_124404708.1	site-specific integrase	-
C4J92_RS17250	3774407..3775117	+	711	WP_124404709.1	hypothetical protein	-
C4J92_RS17255	3775214..3775888	+	675	WP_124404710.1	hypothetical protein	-
C4J92_RS17260	3776375..3776683	-	309	WP_124404711.1	hypothetical protein	-
C4J92_RS17265	3776741..3777061	-	321	WP_122683193.1	hypothetical protein	-
C4J92_RS17270	3777160..3777393	+	234	WP_122683205.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-71)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11073.89 Da
• Isoelectric Point: 10.4037

>T100041 WP_124404707.1 NZ_CP027729:3772336-3772623 [Pseudomonas sp. R3-18-08]
MANEYNVEWDPKALKELRKLDGTVRLQFLKKLQERQTGPRVPGDALHGMKDCYKIKLRGAGYRLVYRVEDERIVILVLAV
GKRERSSVYEQAGRR

Nucleotide

• Length: 288 bp

>T100041 NZ_CP027729:3772336-3772623 [Pseudomonas sp. R3-18-08]
ATGGCCAATGAGTACAACGTCGAGTGGGATCCGAAGGCGCTGAAAGAACTGCGAAAGCTCGATGGTACAGTCCGCCTGCA
GTTTTTGAAAAAACTCCAGGAACGGCAGACCGGACCGCGCGTGCCAGGTGATGCGCTTCACGGCATGAAGGATTGCTACA
AAATCAAATTGCGCGGCGCGGGCTACCGACTGGTGTACCGGGTCGAAGATGAGCGAATTGTCATCCTCGTGTTAGCCGTC
GGTAAACGTGAGCGCAGTTCGGTGTATGAGCAGGCGGGGAGACGATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10140.53 Da
• Isoelectric Point: 4.0470

>AT100041 WP_124367663.1 NZ_CP027729:3772059-3772346 [Pseudomonas sp. R3-18-08]
MQNILADVAVSVSELKKNPSSVLSGANGLPVAVLNHNRVVGYMVPANVYEAMVERLDELELVQLVKARLDANETPVQVSL
DDLIGEAEADIANGQ

Nucleotide

• Length: 288 bp

>AT100041 NZ_CP027729:3772059-3772346 [Pseudomonas sp. R3-18-08]
ATGCAAAACATCCTGGCTGATGTAGCCGTCAGCGTATCCGAACTCAAGAAGAACCCTTCCTCCGTCTTGAGCGGCGCCAA
CGGCTTGCCTGTGGCTGTGCTGAACCACAATCGCGTTGTGGGTTACATGGTCCCTGCCAACGTTTACGAAGCAATGGTCG
AACGCCTGGACGAACTGGAATTAGTCCAACTGGTAAAAGCTCGGCTCGACGCCAACGAAACACCGGTTCAAGTATCGCTC
GACGATCTTATTGGCGAGGCCGAGGCAGATATCGCCAATGGCCAATGA