Detailed information of TA system TA100036

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 1558662..1559175
• Replicon: chromosome
• Accession: NZ_CP027729
• Organism: Pseudomonas sp. R3-18-08

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C4J92_RS07065
• Protein ID: WP_124403367.1
• Coordinates: 1558662..1558946 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C4J92_RS07070
• Protein ID: WP_124361708.1
• Coordinates: 1558936..1559175 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4J92_RS07045	1555133..1555807	+	675	WP_124403364.1	NAD-dependent epimerase/dehydratase family protein	-
C4J92_RS07050	1555900..1557093	+	1194	WP_124403365.1	CoA transferase	-
C4J92_RS07055	1557180..1557668	-	489	WP_124361705.1	DMT family transporter	-
C4J92_RS07060	1557737..1558654	+	918	WP_124403366.1	LysR family transcriptional regulator	-
C4J92_RS07065	1558662..1558946	-	285	WP_124403367.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C4J92_RS07070	1558936..1559175	-	240	WP_124361708.1	ribbon-helix-helix protein, CopG family	Antitoxin
C4J92_RS07075	1559382..1560023	+	642	WP_124403368.1	LysE family translocator	-
C4J92_RS07080	1560144..1560671	+	528	WP_057723086.1	DUF4142 domain-containing protein	-
C4J92_RS07085	1560742..1561167	-	426	WP_124361712.1	low affinity iron permease family protein	-
C4J92_RS07090	1561344..1562126	+	783	WP_124403369.1	GNAT family N-acetyltransferase	-
C4J92_RS07095	1562127..1562627	-	501	WP_124366199.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
C4J92_RS07105	1563042..1563926	-	885	WP_124403370.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-41)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11014.73 Da
• Isoelectric Point: 10.1506

>T100036 WP_124403367.1 NZ_CP027729:c1558946-1558662 [Pseudomonas sp. R3-18-08]
MQVEWLRTALRNLDDEAAFIAEENPKAAYEFVQAILAGIEHIAQFPALGKTGRVPGTREWVVPRWPYIVPYRIREGRLQV
MRIFHTRRQPPTSW

Nucleotide

• Length: 285 bp

>T100036 NZ_CP027729:c1558946-1558662 [Pseudomonas sp. R3-18-08]
ATGCAGGTTGAGTGGCTGAGGACAGCCCTCAGAAACCTGGATGATGAAGCGGCCTTTATTGCTGAAGAAAACCCCAAAGC
CGCCTACGAGTTCGTCCAGGCGATTTTGGCCGGGATTGAACACATTGCGCAATTTCCCGCGCTGGGAAAAACCGGGCGCG
TCCCAGGGACGCGTGAATGGGTGGTGCCCCGGTGGCCCTACATTGTCCCTTACCGTATTCGTGAAGGGCGACTACAGGTG
ATGCGAATTTTTCATACCCGCCGCCAACCACCGACCTCCTGGTAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8597.72 Da
• Isoelectric Point: 4.7571

>AT100036 WP_124361708.1 NZ_CP027729:c1559175-1558936 [Pseudomonas sp. R3-18-08]
MSVMSLRIPDDVADTLASLAKATGRSKSFLAVDALREYLTREAWQIEEIQKALKEADAGDFATAAEVKAVADKWRNNAG

Nucleotide

• Length: 240 bp

>AT100036 NZ_CP027729:c1559175-1558936 [Pseudomonas sp. R3-18-08]
ATGTCTGTTATGTCCCTGCGGATACCGGACGATGTCGCCGATACGCTTGCCAGTCTGGCCAAAGCGACCGGTCGCAGCAA
ATCGTTCCTCGCTGTTGACGCGCTACGTGAATACCTGACACGTGAAGCATGGCAAATCGAAGAGATTCAAAAGGCGCTGA
AAGAAGCTGATGCGGGGGATTTCGCGACGGCTGCCGAGGTAAAAGCCGTCGCTGACAAATGGCGCAACAATGCAGGTTGA