100033

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 4754066..4755108 Replicon chromosome
Accession NZ_CP027728
Organism Pseudomonas sp. R2-37-08W

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag C4J93_RS21920 Protein ID WP_124371779.1
Coordinates 4754066..4754641 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag C4J93_RS21925 Protein ID WP_124430445.1
Coordinates 4754638..4755108 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4J93_RS21885 4749528..4749896 + 369 WP_124430441.1 cupin domain-containing protein -
C4J93_RS21890 4750116..4750445 + 330 WP_124430442.1 hypothetical protein -
C4J93_RS21895 4750407..4751054 - 648 WP_124430443.1 LysE family transporter -
C4J93_RS21900 4751080..4751882 - 803 Protein_4238 2OG-Fe(II) oxygenase -
C4J93_RS21905 4752116..4752808 + 693 WP_124430921.1 helix-turn-helix domain-containing protein -
C4J93_RS21910 4752810..4753439 - 630 WP_124430444.1 LysE family translocator -
C4J93_RS21915 4753576..4753947 + 372 WP_124405218.1 PH domain-containing protein -
C4J93_RS21920 4754066..4754641 - 576 WP_124371779.1 PIN domain-containing protein Toxin
C4J93_RS21925 4754638..4755108 - 471 WP_124430445.1 helix-turn-helix domain-containing protein Antitoxin
C4J93_RS21935 4755608..4755895 + 288 WP_124410715.1 cloacin -
C4J93_RS21940 4755912..4756382 + 471 WP_124430922.1 hypothetical protein -
C4J93_RS21945 4756431..4756805 - 375 WP_124430446.1 cytochrome c family protein -
C4J93_RS21950 4757033..4757413 + 381 WP_124430447.1 response regulator -
C4J93_RS21955 4757607..4758221 + 615 WP_124430448.1 biliverdin-producing heme oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4740949..4757413 16464


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21699.18 Da        Isoelectric Point: 5.0478

>T100033 WP_124371779.1 NZ_CP027728:c4754641-4754066 [Pseudomonas sp. R2-37-08W]
MRCSPFTAVYDACVLYPAALRDLLMWLGLSGLYRARWTRQIHEEWKRNVLKNRPDLTPDQVDKISALMDKAIPDALVTGY
EDLCSSLDLPDPDDRHVLAAAIRSKAEVIVTFNLKDFPVRVLAAYDIEPMHPDDFISDLWDLDQAAVLAAVQKQRRALVR
PPMNGEGYLEMLMRQGLVQTSKLLGPYEVML

Download         Length: 576 bp

>T100033 NZ_CP027728:c4754641-4754066 [Pseudomonas sp. R2-37-08W]
ATGAGGTGTTCGCCTTTCACTGCGGTTTACGACGCCTGTGTTCTGTACCCGGCGGCTCTCAGGGATTTGTTGATGTGGCT
TGGTTTATCCGGGTTGTACCGGGCGCGATGGACCCGACAGATTCATGAAGAGTGGAAGCGTAACGTCCTCAAGAACCGAC
CTGATCTCACTCCCGACCAGGTAGATAAAATTTCGGCATTGATGGACAAGGCCATACCAGACGCGTTGGTAACAGGGTAC
GAAGACTTGTGTTCAAGTTTGGATTTGCCTGATCCAGATGATCGTCACGTACTGGCCGCGGCGATTCGGAGTAAGGCGGA
AGTTATCGTGACCTTTAACTTGAAAGACTTTCCAGTGCGGGTACTCGCGGCTTATGACATAGAACCGATGCATCCCGACG
ACTTTATCTCGGACCTTTGGGACTTGGATCAAGCGGCCGTGTTGGCGGCAGTGCAGAAGCAGAGGCGCGCACTAGTTAGG
CCGCCGATGAATGGGGAAGGGTATCTCGAGATGTTGATGCGGCAGGGGCTAGTGCAGACCAGTAAGCTGCTTGGGCCTTA
TGAAGTAATGTTGTAG

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17680.35 Da        Isoelectric Point: 5.7044

>AT100033 WP_124430445.1 NZ_CP027728:c4755108-4754638 [Pseudomonas sp. R2-37-08W]
MITNRLPKTIPPLEKEVEAAVQGQRELASLLSTKFETQRIDIFDKEDKPHTLVLPTSALRLLVDILGELALGNAVKVVPV
HAELTSQEAADLLNVSRPHLVKMLEEGAIPFTKTGRHRRIRFSDLMAFKQRRDEESQEAMEELVRQTRELGLGYDE

Download         Length: 471 bp

>AT100033 NZ_CP027728:c4755108-4754638 [Pseudomonas sp. R2-37-08W]
ATGATCACCAATCGCCTTCCCAAAACAATTCCTCCGCTGGAAAAGGAAGTCGAAGCCGCTGTGCAAGGCCAACGCGAGCT
GGCTTCGTTGCTATCGACTAAATTCGAAACCCAGCGTATCGACATCTTCGACAAAGAAGACAAGCCCCACACCCTTGTAC
TCCCCACATCCGCGCTGCGCCTGCTGGTTGATATTTTGGGTGAGCTGGCACTGGGTAATGCGGTCAAAGTTGTACCCGTC
CATGCTGAGTTGACCTCCCAGGAAGCTGCCGACCTGCTTAACGTTTCACGCCCGCATCTGGTCAAGATGCTGGAAGAAGG
CGCCATTCCCTTTACGAAGACCGGTCGTCATCGGCGTATTCGATTTTCCGATTTGATGGCGTTCAAACAGCGCCGCGATG
AAGAAAGTCAAGAGGCGATGGAGGAACTGGTACGGCAGACCCGGGAGTTGGGATTGGGGTATGACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References