Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | FaRel2-ATfaRel2/- |
| Location | 23932..24745 | Replicon | chromosome |
| Accession | ACDT02000058 | ||
| Organism | Coprobacillus sp. D7 cont2.58 | ||
Toxin (Protein)
| Gene name | faRel2 | Uniprot ID | - |
| Locus tag | MBAG_03135 | Protein ID | EEO34183.1 |
| Coordinates | 24125..24745 (-) | Length | 207 a.a. |
Antitoxin (Protein)
| Gene name | ATfaRel2 | Uniprot ID | - |
| Locus tag | MBAG_03619 | Protein ID | EQM95769.1 |
| Coordinates | 23932..24153 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MBAG_03126 | 19363..19794 | - | 432 | EEO34174.1 | hypothetical protein | - |
| MBAG_03127 | 19823..20134 | - | 312 | EEO34175.1 | hypothetical protein | - |
| MBAG_03128 | 20357..20839 | - | 483 | EEO34176.1 | hypothetical protein | - |
| MBAG_03129 | 20881..21342 | - | 462 | EEO34177.1 | hypothetical protein | - |
| MBAG_03130 | 21351..21647 | - | 297 | EEO34178.1 | hypothetical protein | - |
| MBAG_03131 | 21666..22025 | - | 360 | EEO34179.1 | hypothetical protein | - |
| MBAG_03132 | 22039..22473 | - | 435 | EEO34180.1 | hypothetical protein | - |
| MBAG_03133 | 22504..22908 | - | 405 | EEO34181.1 | hypothetical protein | - |
| MBAG_03134 | 22909..23292 | - | 384 | EEO34182.1 | hypothetical protein | - |
| MBAG_03619 | 23932..24153 | - | 222 | EQM95769.1 | hypothetical protein | Antitoxin |
| MBAG_03135 | 24125..24745 | - | 621 | EEO34183.1 | hypothetical protein | Toxin |
| MBAG_03136 | 24844..25317 | - | 474 | EEO34184.2 | hypothetical protein | - |
| MBAG_03137 | 25324..25524 | - | 201 | EEO34185.2 | hypothetical protein | - |
| MBAG_03138 | 25545..26009 | - | 465 | EEO34186.1 | hypothetical protein | - |
| MBAG_03139 | 26023..26187 | - | 165 | EEO34187.1 | hypothetical protein | - |
| MBAG_03140 | 26201..26386 | - | 186 | EEO34188.1 | hypothetical protein | - |
| MBAG_03141 | 26390..26674 | - | 285 | EEO34189.1 | hypothetical protein | - |
| MBAG_03142 | 26698..27315 | - | 618 | EEO34190.1 | hypothetical protein | - |
| MBAG_03620 | 27337..27468 | - | 132 | EQM95770.1 | hypothetical protein | - |
| MBAG_03143 | 27484..27909 | - | 426 | EEO34191.1 | hypothetical protein | - |
| MBAG_03144 | 28441..28857 | + | 417 | EEO34192.1 | hypothetical protein | - |
| MBAG_03145 | 28973..29659 | + | 687 | EEO34193.2 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 207 a.a. Molecular weight: 24783.11 Da Isoelectric Point: 5.9697
>T10003 EEO34183.1 ACDT02000058:c24745-24125 [Coprobacillus sp. D7]
MYILDKIGLNIEILESLSYESKLGMSFKRTLSHFNKEEVLKEIELINNWYFSLEIIDDLPLDSRIKSVSSAKMKFERYYP
NATYNRVFNDILGFRVICKSYDEVLELEKEDKIRVVDMSRGKSNDDGYRGIHVYYQRDNHHYPIEIQFNTYYDRQLNDWL
HDKFYKRGYDSSCGQLLRKYYENGKIKSAEELEEVLEDVLYHCKKI
MYILDKIGLNIEILESLSYESKLGMSFKRTLSHFNKEEVLKEIELINNWYFSLEIIDDLPLDSRIKSVSSAKMKFERYYP
NATYNRVFNDILGFRVICKSYDEVLELEKEDKIRVVDMSRGKSNDDGYRGIHVYYQRDNHHYPIEIQFNTYYDRQLNDWL
HDKFYKRGYDSSCGQLLRKYYENGKIKSAEELEEVLEDVLYHCKKI
Download Length: 621 bp
>T10003 ACDT02000058:c24745-24125 [Coprobacillus sp. D7]
ATGTATATACTTGATAAAATAGGACTTAATATTGAAATTCTTGAATCATTGTCATATGAATCAAAATTAGGAATGAGCTT
TAAAAGAACATTGTCTCATTTTAATAAAGAAGAAGTATTGAAAGAAATTGAGCTAATTAATAATTGGTATTTTTCATTAG
AGATAATTGATGATTTACCATTGGATTCACGAATAAAGAGTGTCTCGTCAGCAAAAATGAAATTTGAGCGTTATTATCCA
AATGCAACATACAATAGAGTATTTAATGATATTCTTGGCTTTCGAGTTATATGTAAATCCTATGATGAAGTTCTAGAGTT
AGAGAAAGAGGATAAAATAAGAGTTGTTGATATGTCCAGGGGTAAATCTAATGACGATGGTTATAGGGGGATACATGTTT
ATTATCAGAGGGATAATCATCACTACCCGATAGAAATACAATTTAACACGTATTATGATAGGCAATTAAATGACTGGTTG
CACGATAAGTTTTATAAACGCGGATATGATAGTTCTTGTGGACAATTGTTGCGTAAGTATTATGAAAATGGTAAAATTAA
ATCAGCTGAAGAGCTGGAGGAGGTGCTAGAAGATGTGTTATATCATTGCAAAAAGATTTAA
ATGTATATACTTGATAAAATAGGACTTAATATTGAAATTCTTGAATCATTGTCATATGAATCAAAATTAGGAATGAGCTT
TAAAAGAACATTGTCTCATTTTAATAAAGAAGAAGTATTGAAAGAAATTGAGCTAATTAATAATTGGTATTTTTCATTAG
AGATAATTGATGATTTACCATTGGATTCACGAATAAAGAGTGTCTCGTCAGCAAAAATGAAATTTGAGCGTTATTATCCA
AATGCAACATACAATAGAGTATTTAATGATATTCTTGGCTTTCGAGTTATATGTAAATCCTATGATGAAGTTCTAGAGTT
AGAGAAAGAGGATAAAATAAGAGTTGTTGATATGTCCAGGGGTAAATCTAATGACGATGGTTATAGGGGGATACATGTTT
ATTATCAGAGGGATAATCATCACTACCCGATAGAAATACAATTTAACACGTATTATGATAGGCAATTAAATGACTGGTTG
CACGATAAGTTTTATAAACGCGGATATGATAGTTCTTGTGGACAATTGTTGCGTAAGTATTATGAAAATGGTAAAATTAA
ATCAGCTGAAGAGCTGGAGGAGGTGCTAGAAGATGTGTTATATCATTGCAAAAAGATTTAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8360.74 Da Isoelectric Point: 9.4196
>AT10003 EQM95769.1 ACDT02000058:c24153-23932 [Coprobacillus sp. D7]
MCYIIAKRFKKSGCVALKAKRGKELADFATDLQKKLGYDIQIVAITRPTAYGEYEPYKFVNSFEEFSIEASRL
MCYIIAKRFKKSGCVALKAKRGKELADFATDLQKKLGYDIQIVAITRPTAYGEYEPYKFVNSFEEFSIEASRL
Download Length: 222 bp
>AT10003 ACDT02000058:c24153-23932 [Coprobacillus sp. D7]
ATGTGTTATATCATTGCAAAAAGATTTAAGAAATCAGGTTGTGTTGCATTAAAAGCAAAACGTGGTAAAGAATTAGCTGA
TTTTGCGACAGATTTACAAAAAAAATTAGGATATGATATTCAAATCGTAGCAATTACCAGACCTACTGCGTACGGTGAGT
ATGAGCCATATAAATTTGTGAACAGTTTTGAGGAATTTAGTATTGAGGCTAGTCGATTATAA
ATGTGTTATATCATTGCAAAAAGATTTAAGAAATCAGGTTGTGTTGCATTAAAAGCAAAACGTGGTAAAGAATTAGCTGA
TTTTGCGACAGATTTACAAAAAAAATTAGGATATGATATTCAAATCGTAGCAATTACCAGACCTACTGCGTACGGTGAGT
ATGAGCCATATAAATTTGTGAACAGTTTTGAGGAATTTAGTATTGAGGCTAGTCGATTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|
References
(1) Tatsuaki Kurata et al. (2021) RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis. Molecular Cell 81(15):3160-3170.e9. [PubMed:34174184]
(2) Steffi Jimmy et al. (2020) A widespread toxin-antitoxin system exploiting growth control via alarmone signaling. Proceedings of The National Academy of Sciences of The United States of America 117(19):10500-10510. [PubMed:32345719]