Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | FaRel-ATfaRel/- |
| Location | 28910..30150 | Replicon | chromosome |
| Accession | NZ_BONM01000014 | ||
| Organism | Cellulomonas marina strain NBRC 110784 sequence14 | ||
Toxin (Protein)
| Gene name | faRel | Uniprot ID | - |
| Locus tag | Cma02nite_RS09435 | Protein ID | WP_090034969.1 |
| Coordinates | 29350..30150 (+) | Length | 267 a.a. |
Antitoxin (Protein)
| Gene name | ATfaRel | Uniprot ID | - |
| Locus tag | Cma02nite_RS09430 | Protein ID | WP_090034991.1 |
| Coordinates | 28910..29350 (+) | Length | 147 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| Cma02nite_RS09415 (Cma02nite_18560) | 26272..27468 | + | 1197 | WP_090034980.1 | competence protein CoiA family protein | - |
| Cma02nite_RS09420 (Cma02nite_18570) | 27465..28172 | - | 708 | WP_090034977.1 | YfbU family protein | - |
| Cma02nite_RS09425 (Cma02nite_18580) | 28516..28743 | - | 228 | WP_090034973.1 | hypothetical protein | - |
| Cma02nite_RS09430 (Cma02nite_18590) | 28910..29350 | + | 441 | WP_090034991.1 | HD domain-containing protein | Antitoxin |
| Cma02nite_RS09435 (Cma02nite_18600) | 29350..30150 | + | 801 | WP_090034969.1 | RelA/SpoT domain-containing protein | Toxin |
| Cma02nite_RS09440 (Cma02nite_18610) | 30209..30754 | + | 546 | WP_139224525.1 | hypothetical protein | - |
| Cma02nite_RS09445 (Cma02nite_18620) | 30757..31644 | + | 888 | WP_090034963.1 | hypothetical protein | - |
| Cma02nite_RS09450 (Cma02nite_18640) | 31957..33096 | + | 1140 | WP_090034960.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | - |
| Cma02nite_RS09455 (Cma02nite_18650) | 33093..34007 | + | 915 | WP_239078852.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 11728..79864 | 68136 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 267 a.a. Molecular weight: Da Isoelectric Point:
>T10002 WP_090034969.1 NZ_BONM01000014:29350-30150 [Cellulomonas marina]
MCQSCAEGGRRCRDRRQLEGLTVDELRPGQSEDRPDVVWPNEPAPSTLWDKYPTAVAGEAVATILEACAEESGITSDHLQ
VVPPGARMHALEFRVKSPSSLARKILSRLRRDRVVVGEGTARDVAGRLTDVVRYTAVCVDHEDLPATARSMVTALGTRSY
TVVEAEHSYVDGNPYKGLHLLVASPGGRVFELQIHSELSQSVKDTLHVDYEIERDMDLAWEERAAARERMEKLSASVPTP
AGLDELTTLGDVPVRARTYPNAYATS
MCQSCAEGGRRCRDRRQLEGLTVDELRPGQSEDRPDVVWPNEPAPSTLWDKYPTAVAGEAVATILEACAEESGITSDHLQ
VVPPGARMHALEFRVKSPSSLARKILSRLRRDRVVVGEGTARDVAGRLTDVVRYTAVCVDHEDLPATARSMVTALGTRSY
TVVEAEHSYVDGNPYKGLHLLVASPGGRVFELQIHSELSQSVKDTLHVDYEIERDMDLAWEERAAARERMEKLSASVPTP
AGLDELTTLGDVPVRARTYPNAYATS
Download Length: 801 bp
>T10002 NZ_BONM01000014:29350-30150 [Cellulomonas marina]
ATGTGCCAGTCGTGCGCCGAGGGCGGACGTCGCTGCCGGGACCGTCGCCAGCTCGAAGGGCTCACCGTCGACGAGCTGCG
CCCGGGCCAGAGCGAGGACCGGCCCGACGTCGTCTGGCCGAACGAGCCGGCACCCAGCACGCTGTGGGACAAGTATCCGA
CCGCCGTCGCCGGCGAGGCCGTGGCCACGATCCTCGAGGCCTGCGCCGAGGAGTCCGGCATCACCAGCGACCACCTCCAG
GTCGTGCCCCCGGGCGCGCGCATGCACGCGCTCGAGTTCCGCGTGAAGAGCCCCTCGTCGCTGGCCCGCAAGATCCTGTC
GCGACTGCGCCGAGACCGCGTCGTCGTCGGCGAGGGCACTGCCCGGGACGTGGCCGGCCGGTTGACCGACGTCGTCCGCT
ACACCGCCGTGTGCGTCGACCACGAGGACCTCCCCGCGACGGCGCGCTCCATGGTGACTGCGCTGGGCACCCGCTCGTAC
ACGGTCGTCGAGGCCGAGCACTCCTATGTCGACGGCAACCCCTACAAAGGTCTGCACCTGCTGGTGGCCTCCCCCGGCGG
CCGCGTCTTCGAGCTGCAGATCCACTCCGAGCTCAGCCAGAGCGTGAAGGACACCCTGCACGTCGACTACGAGATCGAGC
GCGACATGGACCTGGCCTGGGAGGAGCGCGCCGCCGCACGTGAACGGATGGAGAAGCTGTCGGCGAGCGTGCCCACGCCG
GCTGGCCTCGACGAGCTCACCACGCTCGGCGACGTGCCGGTCCGGGCGCGCACGTACCCCAACGCTTACGCGACTTCGTA
G
ATGTGCCAGTCGTGCGCCGAGGGCGGACGTCGCTGCCGGGACCGTCGCCAGCTCGAAGGGCTCACCGTCGACGAGCTGCG
CCCGGGCCAGAGCGAGGACCGGCCCGACGTCGTCTGGCCGAACGAGCCGGCACCCAGCACGCTGTGGGACAAGTATCCGA
CCGCCGTCGCCGGCGAGGCCGTGGCCACGATCCTCGAGGCCTGCGCCGAGGAGTCCGGCATCACCAGCGACCACCTCCAG
GTCGTGCCCCCGGGCGCGCGCATGCACGCGCTCGAGTTCCGCGTGAAGAGCCCCTCGTCGCTGGCCCGCAAGATCCTGTC
GCGACTGCGCCGAGACCGCGTCGTCGTCGGCGAGGGCACTGCCCGGGACGTGGCCGGCCGGTTGACCGACGTCGTCCGCT
ACACCGCCGTGTGCGTCGACCACGAGGACCTCCCCGCGACGGCGCGCTCCATGGTGACTGCGCTGGGCACCCGCTCGTAC
ACGGTCGTCGAGGCCGAGCACTCCTATGTCGACGGCAACCCCTACAAAGGTCTGCACCTGCTGGTGGCCTCCCCCGGCGG
CCGCGTCTTCGAGCTGCAGATCCACTCCGAGCTCAGCCAGAGCGTGAAGGACACCCTGCACGTCGACTACGAGATCGAGC
GCGACATGGACCTGGCCTGGGAGGAGCGCGCCGCCGCACGTGAACGGATGGAGAAGCTGTCGGCGAGCGTGCCCACGCCG
GCTGGCCTCGACGAGCTCACCACGCTCGGCGACGTGCCGGTCCGGGCGCGCACGTACCCCAACGCTTACGCGACTTCGTA
G
Antitoxin
Download Length: 147 a.a. Molecular weight: 15483.53 Da Isoelectric Point: 7.4030
>AT10002a WP_090034991.1 NZ_BONM01000014:28910-29350 [Cellulomonas marina]
MDLVTRAREIATAAHRGQVDKAGAPYIEHPKRVAAHAAAAGGDARVLAAAWLHDVVEDTATTPNDLRAAGFPEEVVAAVV
AVTKVAGEPTEAYFARVNADPLAVAVKRADLADNTDPRRLALLEDTTRARLEAKYARARQLLAAAR
MDLVTRAREIATAAHRGQVDKAGAPYIEHPKRVAAHAAAAGGDARVLAAAWLHDVVEDTATTPNDLRAAGFPEEVVAAVV
AVTKVAGEPTEAYFARVNADPLAVAVKRADLADNTDPRRLALLEDTTRARLEAKYARARQLLAAAR
Download Length: 441 bp
>AT10002a NZ_BONM01000014:28910-29350 [Cellulomonas marina]
ATGGATCTGGTGACCAGAGCGCGCGAGATCGCCACGGCCGCGCACCGCGGGCAGGTCGACAAGGCCGGCGCGCCGTACAT
CGAGCACCCGAAGCGGGTCGCCGCGCACGCCGCGGCCGCCGGCGGAGACGCGCGCGTGCTTGCGGCCGCGTGGCTGCACG
ACGTCGTCGAGGACACCGCCACCACGCCCAACGACCTGCGCGCCGCCGGCTTCCCGGAGGAGGTCGTGGCCGCGGTCGTC
GCGGTCACCAAGGTCGCCGGCGAGCCCACCGAGGCCTACTTCGCACGCGTGAACGCCGACCCGCTCGCCGTCGCGGTCAA
GAGAGCAGACCTCGCCGACAACACCGACCCCCGGCGTCTGGCCCTGCTCGAGGACACGACCCGCGCGCGCCTCGAGGCCA
AGTACGCGCGCGCGCGCCAGCTGCTGGCGGCCGCGCGCTGA
ATGGATCTGGTGACCAGAGCGCGCGAGATCGCCACGGCCGCGCACCGCGGGCAGGTCGACAAGGCCGGCGCGCCGTACAT
CGAGCACCCGAAGCGGGTCGCCGCGCACGCCGCGGCCGCCGGCGGAGACGCGCGCGTGCTTGCGGCCGCGTGGCTGCACG
ACGTCGTCGAGGACACCGCCACCACGCCCAACGACCTGCGCGCCGCCGGCTTCCCGGAGGAGGTCGTGGCCGCGGTCGTC
GCGGTCACCAAGGTCGCCGGCGAGCCCACCGAGGCCTACTTCGCACGCGTGAACGCCGACCCGCTCGCCGTCGCGGTCAA
GAGAGCAGACCTCGCCGACAACACCGACCCCCGGCGTCTGGCCCTGCTCGAGGACACGACCCGCGCGCGCCTCGAGGCCA
AGTACGCGCGCGCGCGCCAGCTGCTGGCGGCCGCGCGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|
References
(1) Steffi Jimmy et al. (2020) A widespread toxin-antitoxin system exploiting growth control via alarmone signaling. Proceedings of The National Academy of Sciences of The United States of America 117(19):10500-10510. [PubMed:32345719]