Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 1621555..1622068 Replicon chromosome
Accession NZ_CP027728
Organism Pseudomonas sp. R2-37-08W

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag C4J93_RS07465 Protein ID WP_124428986.1
Coordinates 1621555..1621839 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag C4J93_RS07470 Protein ID WP_124428987.1
Coordinates 1621829..1622068 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4J93_RS07440 1616788..1617936 + 1149 WP_124428983.1 L-threonine dehydrogenase -
C4J93_RS07445 1618028..1618702 + 675 WP_124369937.1 NAD-dependent epimerase/dehydratase family protein -
C4J93_RS07450 1618779..1619987 + 1209 WP_124430854.1 CoA transferase -
C4J93_RS07455 1620074..1620562 - 489 WP_124428984.1 DMT family transporter -
C4J93_RS07460 1620630..1621547 + 918 WP_124428985.1 LysR family transcriptional regulator -
C4J93_RS07465 1621555..1621839 - 285 WP_124428986.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4J93_RS07470 1621829..1622068 - 240 WP_124428987.1 ribbon-helix-helix protein, CopG family Antitoxin
C4J93_RS07475 1622169..1622603 + 435 WP_124428988.1 fosfomycin resistance glutathione transferase -
C4J93_RS07480 1622633..1623274 + 642 WP_124428989.1 LysE family translocator -
C4J93_RS07485 1623395..1623922 + 528 WP_057723086.1 DUF4142 domain-containing protein -
C4J93_RS07490 1623993..1624418 - 426 WP_124428990.1 low affinity iron permease family protein -
C4J93_RS07495 1624595..1625377 + 783 WP_124369941.1 GNAT family N-acetyltransferase -
C4J93_RS07500 1625378..1625878 - 501 WP_124428991.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
C4J93_RS07505 1625978..1626310 - 333 WP_124406521.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-41)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11014.73 Da        Isoelectric Point: 10.1506

>T100028 WP_124428986.1 NZ_CP027728:c1621839-1621555 [Pseudomonas sp. R2-37-08W]
MQVEWLRTALRNLDDEAAFIAEENPKAAYEFVQAILAGLEHLAQFPALGKTGRVPGTREWVVPRWPYIVPYRIREGRLQV
MRIFHTRRQPPTSW

Download         Length: 285 bp

>T100028 NZ_CP027728:c1621839-1621555 [Pseudomonas sp. R2-37-08W]
ATGCAGGTTGAGTGGCTGAGGACAGCCCTCAGAAACCTGGATGATGAAGCGGCCTTTATTGCTGAAGAAAACCCCAAAGC
CGCCTACGAATTCGTCCAGGCGATTTTGGCCGGGCTTGAACACCTTGCGCAATTTCCCGCGCTGGGAAAAACCGGGCGCG
TCCCAGGGACGCGTGAATGGGTGGTGCCCCGGTGGCCCTACATTGTCCCTTACCGTATTCGTGAAGGGCGACTACAGGTG
ATGCGAATTTTTCATACCCGCCGCCAACCACCGACCTCCTGGTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8570.61 Da        Isoelectric Point: 4.3867

>AT100028 WP_124428987.1 NZ_CP027728:c1622068-1621829 [Pseudomonas sp. R2-37-08W]
MSVMSLRIPDDVADTLASLAKATGRSKSFLAVDALREYLTREAWQIEEIQKALTEADAGDFATAAEVNAVAEKWRNNAG

Download         Length: 240 bp

>AT100028 NZ_CP027728:c1622068-1621829 [Pseudomonas sp. R2-37-08W]
ATGTCTGTTATGTCCCTGCGGATACCGGACGATGTCGCTGATACGCTTGCCAGTCTCGCCAAAGCGACCGGTCGCAGCAA
ATCGTTCCTCGCTGTTGACGCGTTACGTGAATACCTGACGCGTGAAGCATGGCAAATCGAAGAGATTCAAAAGGCGCTGA
CGGAAGCTGACGCGGGTGATTTCGCGACGGCTGCCGAGGTAAATGCCGTCGCTGAAAAATGGCGCAACAATGCAGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References