100015

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1929309..1929913 Replicon chromosome
Accession NZ_CP027726
Organism Pseudomonas orientalis strain R4-35-08

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C4J95_RS08805 Protein ID WP_124357693.1
Coordinates 1929309..1929497 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C4J95_RS08810 Protein ID WP_124357694.1
Coordinates 1929509..1929913 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4J95_RS08780 1925749..1926285 + 537 WP_124357689.1 DsbE family thiol:disulfide interchange protein -
C4J95_RS08785 1926282..1926755 + 474 WP_057722736.1 cytochrome c-type biogenesis protein CcmH -
C4J95_RS08790 1926748..1927932 + 1185 WP_124357690.1 c-type cytochrome biogenesis protein CcmI -
C4J95_RS08795 1927948..1928343 + 396 WP_124357691.1 hypothetical protein -
C4J95_RS08800 1928615..1929181 + 567 WP_124357692.1 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN -
C4J95_RS08805 1929309..1929497 + 189 WP_124357693.1 type II toxin-antitoxin system HicA family toxin Toxin
C4J95_RS08810 1929509..1929913 + 405 WP_124357694.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C4J95_RS08815 1929910..1931106 - 1197 WP_124357695.1 MFS transporter -
C4J95_RS08820 1931393..1932397 - 1005 WP_124357696.1 sulfate ABC transporter substrate-binding protein -
C4J95_RS08825 1932494..1933318 - 825 WP_124357697.1 ion transporter -
C4J95_RS08830 1933350..1934225 - 876 WP_124357698.1 urea transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7190.42 Da        Isoelectric Point: 11.2000

>T100015 WP_124357693.1 NZ_CP027726:1929309-1929497 [Pseudomonas orientalis]
VQSRLLIKELLEAGWVLDRVTGSHHIFTHRYNPYTIPVPHPKKDLPVGTVRSIRKRAGLFQF

Download         Length: 189 bp

>T100015 NZ_CP027726:1929309-1929497 [Pseudomonas orientalis]
GTGCAAAGCAGGCTATTGATCAAGGAATTGCTGGAAGCGGGCTGGGTGCTGGATCGAGTCACCGGCAGCCATCACATTTT
CACCCACCGCTATAACCCGTACACGATACCGGTGCCTCATCCGAAGAAGGATCTGCCTGTGGGCACCGTCAGAAGCATCA
GGAAACGCGCCGGACTGTTTCAGTTCTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14654.58 Da        Isoelectric Point: 4.4765

>AT100015 WP_124357694.1 NZ_CP027726:1929509-1929913 [Pseudomonas orientalis]
MQYPICIEWGDDFTATGIQIPDIPGAVTAGDTFEEAYNAAVEVAHILLQEIAAEGGVIPLPTSVATHHAHEDYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAALEKLVRS

Download         Length: 405 bp

>AT100015 NZ_CP027726:1929509-1929913 [Pseudomonas orientalis]
ATGCAATACCCAATCTGTATCGAATGGGGCGATGACTTTACCGCCACCGGTATTCAGATCCCCGACATTCCGGGTGCCGT
CACCGCCGGTGACACTTTCGAAGAGGCCTACAACGCGGCCGTTGAGGTTGCGCACATCCTGCTGCAGGAGATTGCCGCAG
AGGGCGGGGTGATTCCGTTGCCAACGTCGGTCGCCACTCATCACGCCCATGAAGACTACGCCGGTATGGGCTGGGGCATG
TTGGAGCTGGATATCTCGCCTTATCTGGGCAAGACCGAGAAGGTCAATGTGACCTTGCCCGGTTATGTGATCCAACGCAT
CGACCGTTACGTGCGTGAACACAACGTCAAAAGCCGCTCGTCATTTCTGGCGGATGCGGCTTTGGAAAAGTTGGTGCGTT
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References