Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1857523..1858127 Replicon chromosome
Accession NZ_CP027725
Organism Pseudomonas orientalis strain R2-66-08W

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C4J96_RS08425 Protein ID WP_124357693.1
Coordinates 1857523..1857711 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C4J96_RS08430 Protein ID WP_124357694.1
Coordinates 1857723..1858127 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4J96_RS08400 1853963..1854499 + 537 WP_124426303.1 DsbE family thiol:disulfide interchange protein -
C4J96_RS08405 1854496..1854969 + 474 WP_057722736.1 cytochrome c-type biogenesis protein CcmH -
C4J96_RS08410 1854962..1856146 + 1185 WP_124357690.1 c-type cytochrome biogenesis protein CcmI -
C4J96_RS08415 1856162..1856557 + 396 WP_124357691.1 hypothetical protein -
C4J96_RS08420 1856829..1857395 + 567 WP_124357692.1 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN -
C4J96_RS08425 1857523..1857711 + 189 WP_124357693.1 type II toxin-antitoxin system HicA family toxin Toxin
C4J96_RS08430 1857723..1858127 + 405 WP_124357694.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C4J96_RS08435 1858124..1859320 - 1197 WP_082631987.1 MFS transporter -
C4J96_RS08440 1859629..1860633 - 1005 WP_124357696.1 sulfate ABC transporter substrate-binding protein -
C4J96_RS08445 1860730..1861554 - 825 WP_124357697.1 ion transporter -
C4J96_RS08450 1861586..1862461 - 876 WP_124426304.1 urea transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7190.42 Da        Isoelectric Point: 11.2000

>T100008 WP_124357693.1 NZ_CP027725:1857523-1857711 [Pseudomonas orientalis]
VQSRLLIKELLEAGWVLDRVTGSHHIFTHRYNPYTIPVPHPKKDLPVGTVRSIRKRAGLFQF

Download         Length: 189 bp

>T100008 NZ_CP027725:1857523-1857711 [Pseudomonas orientalis]
GTGCAAAGCAGGCTATTGATCAAGGAATTGCTGGAAGCGGGCTGGGTGCTGGATCGAGTCACCGGCAGCCATCACATTTT
CACCCACCGCTATAACCCGTACACGATACCGGTGCCTCATCCGAAGAAGGATCTGCCTGTGGGCACCGTCAGAAGCATCA
GGAAACGCGCCGGACTGTTTCAGTTCTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14654.58 Da        Isoelectric Point: 4.4765

>AT100008 WP_124357694.1 NZ_CP027725:1857723-1858127 [Pseudomonas orientalis]
MQYPICIEWGDDFTATGIQIPDIPGAVTAGDTFEEAYNAAVEVAHILLQEIAAEGGVIPLPTSVATHHAHEDYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAALEKLVRS

Download         Length: 405 bp

>AT100008 NZ_CP027725:1857723-1858127 [Pseudomonas orientalis]
ATGCAATACCCAATCTGTATCGAATGGGGCGATGACTTTACCGCCACCGGTATTCAGATCCCCGACATTCCGGGTGCCGT
CACCGCCGGTGACACTTTCGAAGAGGCCTACAACGCGGCCGTTGAGGTTGCGCACATCCTGCTGCAGGAGATTGCCGCAG
AGGGCGGGGTGATTCCGTTGCCAACGTCGGTCGCCACTCATCACGCCCATGAAGACTACGCCGGTATGGGCTGGGGCATG
TTGGAGCTGGATATCTCGCCTTATCTGGGCAAGACCGAGAAGGTCAATGTGACCTTGCCCGGTTATGTGATCCAACGCAT
CGACCGTTACGTGCGTGAACACAACGTCAAAAGCCGCTCGTCATTTCTGGCGGATGCGGCTTTGGAAAAGTTGGTGCGTT
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References