Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 910303..910942 Replicon chromosome
Accession NZ_CP027725
Organism Pseudomonas orientalis strain R2-66-08W

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C4J96_RS03980 Protein ID WP_124425987.1
Coordinates 910303..910485 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C4J96_RS03985 Protein ID WP_124357017.1
Coordinates 910541..910942 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4J96_RS03965 906181..908469 - 2289 WP_124425985.1 TonB-dependent siderophore receptor -
C4J96_RS03970 908674..909354 + 681 WP_124357014.1 Fe2+-dependent dioxygenase -
C4J96_RS03975 909356..910105 + 750 WP_124425986.1 sel1 repeat family protein -
C4J96_RS03980 910303..910485 + 183 WP_124425987.1 type II toxin-antitoxin system HicA family toxin Toxin
C4J96_RS03985 910541..910942 + 402 WP_124357017.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C4J96_RS03990 911015..912178 - 1164 WP_003188470.1 type III PLP-dependent enzyme -
C4J96_RS03995 912614..913771 - 1158 WP_057701635.1 ABC transporter ATP-binding protein -
C4J96_RS04000 913768..914421 - 654 WP_057726112.1 ABC transporter permease -
C4J96_RS04005 914434..915327 - 894 WP_124357018.1 glycine betaine ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6744.84 Da        Isoelectric Point: 11.0738

>T100007 WP_124425987.1 NZ_CP027725:910303-910485 [Pseudomonas orientalis]
MRSREVIELLVADGWFEVAAKGSHHQFKHPVKRGRVTVPHPKSEIAKGTLHSIYRSAGLK

Download         Length: 183 bp

>T100007 NZ_CP027725:910303-910485 [Pseudomonas orientalis]
ATGAGAAGTCGAGAGGTGATTGAGCTACTGGTTGCGGATGGTTGGTTTGAGGTGGCAGCGAAGGGAAGCCATCACCAATT
TAAACATCCGGTGAAGCGGGGGCGAGTGACGGTCCCTCATCCCAAGTCAGAAATTGCCAAGGGCACTCTGCATAGTATTT
ACAGATCAGCAGGCCTCAAATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14411.16 Da        Isoelectric Point: 4.4720

>AT100007 WP_124357017.1 NZ_CP027725:910541-910942 [Pseudomonas orientalis]
MKFPVVVHKDADSDYSVTVPDVPGCFSAGGSFSEALDNVREALALHLEGLVADQEALPQALEVDAHLGNPDFAGGVWAIV
DFDLTPYLGKSVRFNASLPEQLLQRIDERVQKDHRYASRSGFLATAALRELSA

Download         Length: 402 bp

>AT100007 NZ_CP027725:910541-910942 [Pseudomonas orientalis]
ATGAAGTTTCCCGTGGTAGTCCATAAAGATGCTGACTCGGATTACAGCGTAACGGTCCCGGACGTACCAGGATGTTTCTC
GGCCGGAGGATCTTTTTCCGAAGCGCTGGACAATGTCCGTGAGGCTCTCGCGCTACATTTGGAGGGGTTGGTGGCAGATC
AGGAAGCGCTTCCCCAGGCACTGGAGGTCGATGCCCATCTGGGTAATCCGGATTTTGCTGGGGGCGTATGGGCGATAGTC
GACTTTGATCTGACGCCTTATCTGGGCAAGTCAGTCCGATTCAATGCTTCCTTGCCCGAGCAGTTGCTGCAACGCATTGA
TGAGCGGGTGCAGAAGGATCATCGCTATGCGTCGAGGTCAGGTTTTCTGGCGACGGCGGCACTGCGTGAGCTGTCTGCAT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References