Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1855847..1856451 Replicon chromosome
Accession NZ_CP027724
Organism Pseudomonas orientalis strain L1-3-08

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C4J97_RS08395 Protein ID WP_124357693.1
Coordinates 1855847..1856035 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C4J97_RS08400 Protein ID WP_124422944.1
Coordinates 1856047..1856451 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4J97_RS08365 1850895..1851368 + 474 WP_124422941.1 cytochrome c-type biogenesis protein CcmH -
C4J97_RS08370 1851361..1852545 + 1185 WP_124422942.1 c-type cytochrome biogenesis protein CcmI -
C4J97_RS08375 1852561..1852956 + 396 WP_124357691.1 hypothetical protein -
C4J97_RS08385 1854529..1854675 - 147 Protein_1621 DUF3077 domain-containing protein -
C4J97_RS08390 1855153..1855719 + 567 WP_124422943.1 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN -
C4J97_RS08395 1855847..1856035 + 189 WP_124357693.1 type II toxin-antitoxin system HicA family toxin Toxin
C4J97_RS08400 1856047..1856451 + 405 WP_124422944.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C4J97_RS08405 1856448..1857644 - 1197 WP_124422945.1 MFS transporter -
C4J97_RS08410 1857953..1858957 - 1005 WP_124422946.1 sulfate ABC transporter substrate-binding protein -
C4J97_RS08415 1859054..1859878 - 825 WP_124422947.1 ion transporter -
C4J97_RS08420 1859910..1860785 - 876 WP_124422948.1 urea transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1853117..1853914 797


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7190.42 Da        Isoelectric Point: 11.2000

>T100002 WP_124357693.1 NZ_CP027724:1855847-1856035 [Pseudomonas orientalis]
VQSRLLIKELLEAGWVLDRVTGSHHIFTHRYNPYTIPVPHPKKDLPVGTVRSIRKRAGLFQF

Download         Length: 189 bp

>T100002 NZ_CP027724:1855847-1856035 [Pseudomonas orientalis]
GTGCAAAGCAGGCTATTGATCAAGGAATTGCTGGAAGCGGGCTGGGTGCTGGATCGAGTCACCGGCAGCCATCACATTTT
CACCCACCGCTATAACCCGTACACGATACCGGTGCCTCATCCGAAGAAGGATCTGCCTGTGGGCACCGTCAGAAGCATCA
GGAAACGCGCCGGACTGTTTCAGTTCTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14702.64 Da        Isoelectric Point: 4.4765

>AT100002 WP_124422944.1 NZ_CP027724:1856047-1856451 [Pseudomonas orientalis]
MQYPICIEWGDDFTATGIQIPDIPGAVTAGDTFEEAYNAAVEVAHILLQEIAAEGGVIPMPTSVATHHTHEDYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAALEKLVRS

Download         Length: 405 bp

>AT100002 NZ_CP027724:1856047-1856451 [Pseudomonas orientalis]
ATGCAATACCCAATCTGTATCGAATGGGGCGATGACTTTACCGCCACCGGTATTCAGATCCCCGACATTCCGGGTGCCGT
CACCGCCGGTGACACTTTTGAAGAGGCCTACAACGCGGCCGTGGAAGTGGCGCACATCCTGCTGCAGGAGATCGCCGCAG
AGGGCGGTGTTATTCCGATGCCAACCTCGGTCGCCACTCATCACACCCATGAAGACTACGCCGGCATGGGCTGGGGCATG
TTGGAGCTGGATATCTCGCCTTATCTGGGCAAGACCGAGAAGGTCAATGTGACTTTGCCCGGTTATGTGATCCAACGCAT
CGACCGTTATGTGCGCGAGCACAACGTCAAAAGCCGCTCGTCATTCCTGGCGGATGCGGCTTTGGAGAAGTTGGTGCGTT
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References