| Effector Protein ID: 319898800 |
 T4SS name [ID] | VirB [230] |
| Gene symbol | - |
| Locus tag | BARCL_0631 |
| Strain | Bartonella clarridgeiae 73 |
| Replicon | chromosome [GenBank: NC_014932] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 691657..693285 [+] |
| Product | Bartonella effector protein (Bep); substrate of VirB T4SS |
| Effector type | Protein |
| Descripton | BepA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Homologous to BepA protein of Bartonella henselae. The Bartonella-translocated effector protein (BepA-BepG) are required for invasion, proinflammatory activation and antiapoptotic protection of endothelial cells. |
| UniProt ID | E6YHH4 |
| KEGG ID | bcd:BARCL_0631 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Fic [PF02661], Evalue: 4.8e-12, Aligned region: 57..169 |
| Protein Sequence: 542 a.a. [Download] |
| >gi|319898800|ref|YP_004158893.1| Bartonella effector protein (Bep); substrate of VirB T4SS [Bartonella clarridgeiae 73] MTTSSDISLARNYAYPNSKTLKNKYGIMDFKKLEKKCTHDAKKVIVNLHQEPLPEKFDSSYLKYLHKCLF EDAFEWAGHTRDLPFTFKDGTTAQMLMMKMPNSNIFFVASNKIQESLQEFDQMLVAKNNLQGLSREEFID EAAKLFSSLNYIHPFRGGNEPTQQMFFEKLAEAAGHRIDFSIVTQERMIRACTDAITLKGDEAHEAMKHL FEDISNPEKVRVLKELLNHIPRLECKRLDNEYVVMPREGMTYTGIYKGGSLDSIIVETVDSCVICHKDYL TPEQIKALKPGNRVTFTVPINKDLDQILIPAEKLAPLREEEIIKKIKNTDCIKESRKGIDHLLKLVYGDP TILDKHMNLINKDPEMGQQLAEQIRNSPKSISKLAGFKIWRIRSPKRRVAERNISSLSRAITQHVQIVKS VKDKIFIEYKRKQKRLEQVVKIPSKEVRESLNLPKDIQKKALESSPSLHRDLCDFLCKVNSRLSMSELEH IRDTNHKILAESIGISQSKAKIITQTFNKGVKLYKQFETIKADRSKIAAMTI |
| - |
| Nucleotide Sequence: 1629 bp [Download] |
| >gi|319898193|ref|NC_014932.1|:691657-693285 Bartonella clarridgeiae 73, complete genome ATGACAACATCTTCCGATATATCCTTAGCCCGTAATTATGCCTATCCTAACAGTAAAACATTAAAGAATA AATATGGAATAATGGATTTTAAAAAACTTGAAAAGAAATGTACACATGATGCAAAAAAAGTAATCGTCAA TTTGCATCAAGAACCGCTACCAGAAAAGTTTGATTCTTCTTATTTAAAATATCTCCATAAATGCTTATTT GAAGACGCATTTGAATGGGCCGGACATACCCGCGATCTCCCCTTTACATTTAAAGACGGCACAACTGCCC AAATGTTAATGATGAAAATGCCGAATTCAAATATTTTTTTTGTAGCTAGTAACAAAATTCAAGAAAGCTT ACAGGAATTTGACCAAATGCTTGTTGCAAAGAATAATTTGCAAGGTTTATCGCGCGAAGAATTTATTGAT GAGGCAGCAAAACTTTTTTCTTCTCTCAACTATATACATCCTTTCAGAGGTGGTAATGAACCTACACAAC AAATGTTTTTTGAAAAGCTTGCGGAAGCTGCAGGTCATAGAATTGATTTTTCAATTGTGACACAAGAACG CATGATACGTGCTTGTACTGATGCGATAACTCTAAAAGGTGATGAAGCTCATGAAGCGATGAAACATTTA TTTGAAGATATTTCCAATCCAGAAAAAGTACGTGTTTTAAAGGAATTACTCAATCACATACCTAGGCTTG AGTGCAAACGTTTGGATAATGAATATGTTGTAATGCCACGTGAAGGTATGACCTATACAGGTATTTACAA AGGAGGTAGTTTAGATTCTATTATAGTTGAAACAGTGGATTCTTGCGTCATATGTCATAAAGATTATCTT ACACCAGAACAAATCAAGGCATTAAAACCCGGTAATCGGGTTACCTTTACAGTTCCAATAAATAAAGATT TAGATCAAATTCTTATCCCAGCAGAAAAGTTAGCTCCTTTGAGGGAAGAGGAAATAATCAAAAAGATTAA AAATACTGATTGTATTAAAGAAAGCCGAAAAGGAATTGACCATTTATTAAAGCTTGTTTATGGAGATCCA ACAATATTAGATAAGCATATGAATCTTATTAATAAAGATCCTGAAATGGGTCAACAGCTTGCCGAACAGA TTAGAAATTCTCCTAAATCTATTTCTAAACTCGCAGGCTTCAAAATATGGCGTATAAGGAGTCCAAAACG CAGGGTAGCTGAAAGAAATATTTCAAGCCTCAGTCGAGCAATTACACAACATGTGCAAATTGTAAAATCT GTTAAAGATAAAATTTTTATAGAGTATAAAAGAAAACAAAAACGACTTGAGCAAGTAGTAAAAATACCTA GTAAAGAAGTGCGAGAGAGTCTTAATTTGCCAAAGGATATACAAAAAAAAGCTTTAGAGTCTTCTCCTTC ACTTCACAGAGATCTTTGTGATTTTCTGTGTAAAGTCAATTCTCGTCTTTCAATGAGTGAGCTAGAACAT ATTCGTGATACTAATCATAAAATACTGGCTGAAAGTATTGGCATATCACAAAGTAAAGCGAAGATAATTA CACAAACTTTTAATAAAGGAGTAAAATTATACAAACAATTTGAAACAATCAAAGCTGACCGTTCGAAAAT AGCGGCTATGACCATCTGA |
| Reference |
(1) Engel P; Salzburger W; Liesch M; Chang CC; Maruyama S; Lanz C; Calteau A; Lajus A; Medigue C; Schuster SC; Dehio C (2011). Parallel evolution of a type IV secretion system in radiating lineages of the host-restricted bacterial pathogen Bartonella. PLoS Genet. 7(2):e1001296. [PudMed:21347280]  
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| experimental literature |
| in silico analysis literature |