| Effector Protein ID: 319898799 |
 T4SS name [ID] | VirB [230] |
| Gene symbol | - |
| Locus tag | BARCL_0630 |
| Strain | Bartonella clarridgeiae 73 |
| Replicon | chromosome [GenBank: NC_014932] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 689727..691361 [+] |
| Product | Bartonella effector protein (Bep), substrate of VirB T4SS |
| Effector type | Protein |
| Descripton | BepA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Homologous to BepA protein of Bartonella henselae. The Bartonella-translocated effector protein (BepA-BepG) are required for invasion, proinflammatory activation and antiapoptotic protection of endothelial cells. |
| UniProt ID | E6YHH3 |
| KEGG ID | bcd:BARCL_0630 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Fic [PF02661], Evalue: 1.1e-13, Aligned region: 57..170 |
| Protein Sequence: 544 a.a. [Download] |
| >gi|319898799|ref|YP_004158892.1| Bartonella effector protein (Bep), substrate of VirB T4SS [Bartonella clarridgeiae 73] MTISSDISLARNYAYPNSKTLKNKYGIMDFKKLEKKCTHDAKKVIVNLHQEPLPEKFDSSYLKYLHKCLF EEAFEWAGHTRDLPFTFKDGTTAQMLMMKMPNSNIFFVAGNKIQESLQEFDQMLVAKNNLQGLSREEFID EAAKLFSSLNYIHPFRGGNGPTQRVFFEKLAEAAGHRIDFSVITKERMIRTCINAIMLKGDEAHEAMKHL FEDISNPEKVRVLKELFNHIPRLECKRLDNEYVVMPREGMTYTGIYKGGSLDSIIVETVDSCVICHKDYL TPEQIKALKFSDEITFTVPINKDLDQILIPAEKLAPLREEEIIKKIENATYVQKSRIKIEFLSKLVYGDP TILDKHMNLINKDPEMGQQLAEQIRNSPKSISKLEGFKIGLIRSPKREVAERNISEFSKAIIEHVDIVQY TKRKILKEHQKEKKRVEQVIKRPSQEVQKILELQPNKWEEALKTESPEVLHKDLRGFLNKINSRLSISER KNIDSADCETLAESIGISDSKAKIIIQAFHQGTELYKQLEIIKTDRSKVVTMAI |
| - |
| Nucleotide Sequence: 1635 bp [Download] |
| >gi|319898193|ref|NC_014932.1|:689727-691361 Bartonella clarridgeiae 73, complete genome ATGACAATATCTTCCGATATATCCTTAGCCCGTAATTATGCCTATCCTAACAGTAAAACATTAAAGAATA AATATGGAATAATGGATTTTAAAAAACTTGAAAAGAAATGCACACATGATGCAAAAAAAGTAATCGTCAA TTTGCATCAAGAACCGCTACCAGAAAAGTTTGATTCTTCTTATTTAAAATATCTCCATAAATGCTTATTT GAAGAGGCATTTGAATGGGCCGGACATACCCGCGATCTCCCCTTTACATTTAAAGACGGCACAACTGCCC AAATGTTAATGATGAAAATGCCGAATTCAAATATTTTTTTTGTAGCTGGTAACAAAATTCAAGAAAGCTT ACAGGAATTTGACCAAATGCTTGTTGCAAAGAATAATTTGCAAGGTTTATCGCGCGAAGAATTTATTGAT GAGGCAGCAAAGCTTTTTTCTTCTCTCAACTATATACATCCTTTCAGAGGTGGTAATGGACCTACACAGC GAGTATTTTTTGAAAAGCTTGCGGAAGCTGCAGGTCATAGAATTGATTTTTCAGTTATAACAAAAGAGCG GATGATACGCACCTGTATTAATGCGATAATGCTAAAGGGTGATGAAGCTCATGAAGCGATGAAACATTTA TTTGAAGATATTTCCAATCCAGAAAAAGTACGTGTTTTAAAGGAATTATTCAATCACATACCTAGGCTTG AGTGCAAACGTTTGGATAATGAATATGTTGTAATGCCACGTGAAGGTATGACCTATACAGGTATTTATAA AGGAGGTAGTTTAGATTCTATCATAGTTGAAACAGTGGATTCTTGCGTCATATGTCATAAAGATTATCTT ACACCAGAACAAATCAAGGCATTAAAATTCAGTGACGAAATTACCTTTACAGTTCCAATAAATAAAGATT TAGATCAAATTCTTATCCCAGCAGAAAAGTTAGCTCCTTTGAGGGAAGAGGAAATAATCAAGAAGATTGA AAATGCTACTTATGTTCAAAAAAGCCGAATAAAAATCGAGTTTTTATCAAAGCTTGTTTATGGAGATCCA ACAATATTAGATAAGCATATGAATCTTATTAATAAAGATCCTGAAATGGGTCAACAGCTTGCCGAACAGA TTAGAAATTCTCCTAAATCTATTTCTAAGCTTGAAGGTTTCAAAATAGGGCTTATAAGGAGTCCAAAACG CGAGGTAGCTGAAAGAAATATTTCAGAATTTAGTAAAGCAATTATAGAACACGTGGATATTGTACAATAT ACTAAAAGGAAAATTCTTAAAGAGCATCAAAAAGAAAAAAAACGTGTTGAACAAGTAATAAAAAGGCCTA GCCAAGAAGTGCAAAAGATTCTTGAATTGCAACCAAATAAATGGGAAGAAGCTTTAAAGACAGAGAGTCC TGAAGTGCTTCATAAAGATCTCCGCGGTTTTTTGAATAAAATCAATTCTCGTCTTTCTATAAGCGAGCGG AAAAATATCGATTCTGCTGATTGTGAAACATTGGCTGAAAGTATTGGCATATCAGACAGTAAAGCAAAGA TAATTATACAAGCTTTTCATCAAGGCACAGAATTATACAAACAGCTTGAAATAATTAAAACTGACCGCTC GAAAGTAGTGACTATGGCCATCTGA |
| Reference |
(1) Engel P; Salzburger W; Liesch M; Chang CC; Maruyama S; Lanz C; Calteau A; Lajus A; Medigue C; Schuster SC; Dehio C (2011). Parallel evolution of a type IV secretion system in radiating lineages of the host-restricted bacterial pathogen Bartonella. PLoS Genet. 7(2):e1001296. [PudMed:21347280]  
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| experimental literature |
| in silico analysis literature |