| Effector Protein ID: 208434469 |
 T4SS name [ID] | Cag [39] |
| Gene symbol | cagA |
| Locus tag | HPG27_507 |
| Strain | Helicobacter pylori G27 |
| Replicon | chromosome [GenBank: NC_011333] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 548263..551955 [+] |
| Product | cytotoxin-associated protein A |
| Effector type | Protein |
| Descripton | CagA |
| T4CP requirement | T4CP Depedent |
| Target/Effection | CagA can cause gastritis and peptic ulcer, Injected CagA can act as a ‘master key’ that evolved the ability to highjack multiple host cell signalling cascades, which include the induction of membrane dynamics, actin-cytoskeletal rearrangements and the disruption of cell-to-cell junctions as well as proliferative, pro-inflammatory and anti-apoptotic nuclear responses (Backert et al, 2010). |
| UniProt ID | B5Z6S0 |
| KEGG ID | hpg:HPG27_507 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | CagA [PF03507], Evalue: 8.6e-132, Aligned region: 864..995 CagA [PF03507], Evalue: 8.6e-132, Aligned region: 981..1088 |
| Protein Sequence: 1230 a.a. [Download] |
| >gi|208434469|ref|YP_002266135.1| cytotoxin-associated protein A [Helicobacter pylori G27] MTNETINQQPQTEAAFNPQQFINNLQVAFLKVDNAVASYDPDQKPIVDKNDRDNRQAFNGISQLREEYSN KAIKNPAKKNQYFSDFIDKSNNLINKDALIDVESSTKSFQKFGDQRYQIFTSWVSHQNDPSKINTRSIRN FMENIIQPPIPDDKEKAEFLKSAKQSFAGIIIGNQIRTDQKFMGVFDESLKERQEAEKNGGPTGGDWLDI FLSFIFDKKQSSDVKEAINQEPVPHVQPDIATTTTDIQGLPPEARDLLDERGNFSKFTLGDMEMLDVEGV ADIDPNYKFNQLLIHNNALSSVLMGSHNGIEPEKVSLLYGGNGGPKAKHDWNATVGYKDQQGNNVATIIN VHMKNGSGLVIAGGEKGINNPSFYLYKEDQLTGSQRALSQEEIRNKVDFMEFLAQNNAKLDNLSEKEEEK FRNEIKDFQKDSKAYLDALGNDRIAFVSKKDTKHSALITEFGNGDLSYTLKDYGKKADKALDREKNVTLQ GNLKHDGVMFVDYSNFKYTNASKNPNKGVGVTNGVSHLEAGFSKVAVFNLPDLNNLAITSLVRRDLEDKL IAKGLSPQETNKLVKDFLSSNKELVGKALNFNKAVAEAKNTGNYDEVKQAQKDLEKSLKKRERLEKEVAK KLESKSGNKNKMEAKSQANSQKDEIFALINKEANREARAITYAQNLKGIKRELSDKLENVNKNLKDFSKS FDEFKNGKNKDFSKSEETLKALKGSVKDLGINPEWISKVENLNAALNEFKNGKNKDFSKVTQAKSDLENS VKDVIINQKVTDKVDNLNQAVSVAKATGDFSRVEQALADLKNFSKEQLAQQAQKNEDFNTGKNSALYQSV KNGVNGTLVGNGLSKAEATTLSKNFSDIKKELNAKLGNFNNNNNNGLKNSTEPIYAKVNKKKAGQAASPE EPIYAQVAKKVNAKIDRLNQIASGLGVVGQAVGFPLKRHDKVGDLSKVGQSVSPEPIYATIDDLGGPFPL KRHDKVGDLSKVGLSVSPEPIYATIDDLGGPFPLKRHDKVGDLSKVGLSREQQLKQKIDNLSQAVSEAKA GFFGNLEQTIDNLKDSAKNNPVSLWAEGAKKVPASLSAKLDNYATNSHTRINSNIQSGAINEKATGMLTQ KNPEWLKLVNDKIVAHNVGSVPLLEYDKIGFNQKSMKDYSDSFKFSTELNNAVKDVKSGFTQFLANAFST GYYRLAGENAEHGIKNVNTKGGSKNLKGLRNTKNAKTTPC |
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| Nucleotide Sequence: 3693 bp [Download] |
| >gi|208433976|ref|NC_011333.1|:548263-551955 Helicobacter pylori G27 chromosome, complete genome ATGACTAACGAAACCATTAACCAACAACCACAAACTGAAGCGGCTTTTAACCCGCAGCAATTTATCAATA ATCTTCAAGTGGCTTTTCTTAAAGTTGATAACGCTGTCGCTTCATACGATCCTGATCAAAAACCAATCGT TGATAAGAACGATAGGGATAACAGGCAAGCTTTTAATGGAATCTCGCAATTAAGGGAAGAATACTCCAAT AAAGCGATCAAAAATCCTGCCAAAAAGAATCAGTATTTTTCAGACTTTATCGATAAGAGCAATAATTTAA TCAACAAAGACGCTCTCATTGATGTAGAATCTTCCACAAAGAGCTTTCAGAAATTTGGGGATCAGCGTTA CCAAATTTTCACAAGTTGGGTGTCCCATCAAAACGATCCGTCTAAAATCAACACCCGATCGATCCGAAAT TTTATGGAAAATATCATACAACCCCCTATCCCTGATGATAAAGAAAAAGCAGAGTTTTTGAAATCTGCCA AACAATCTTTTGCAGGAATTATCATAGGGAATCAAATCCGAACGGATCAAAAGTTCATGGGCGTGTTTGA TGAATCCTTGAAAGAAAGGCAAGAAGCAGAAAAAAATGGAGGGCCTACTGGTGGGGATTGGTTGGATATT TTTCTCTCATTTATATTTGACAAAAAACAATCTTCTGATGTCAAAGAAGCAATCAATCAAGAACCAGTTC CCCATGTCCAACCAGATATAGCCACTACCACCACCGACATACAAGGCTTACCGCCTGAAGCTAGAGATTT ACTTGATGAAAGGGGTAATTTTTCTAAATTCACTCTTGGCGATATGGAAATGTTAGATGTTGAGGGAGTC GCTGACATTGATCCTAATTACAAGTTCAACCAATTATTGATTCACAATAACGCTCTGTCTTCTGTGTTAA TGGGGAGTCATAATGGCATAGAACCTGAAAAAGTTTCATTGTTGTATGGGGGCAATGGTGGTCCTAAAGC TAAGCATGATTGGAACGCCACCGTTGGTTATAAAGACCAACAAGGTAACAATGTGGCTACAATAATTAAT GTGCATATGAAAAACGGCAGTGGCTTAGTCATAGCAGGTGGTGAGAAAGGGATTAATAATCCTAGTTTTT ATCTCTACAAAGAAGACCAACTCACAGGCTCACAACGAGCATTGAGTCAAGAAGAGATCCGAAACAAAGT AGATTTCATGGAATTTCTTGCACAAAATAATGCTAAATTAGACAACTTGAGCGAGAAAGAGGAAGAAAAA TTCCGAAATGAGATTAAGGATTTCCAAAAAGACTCTAAGGCTTATTTAGACGCCCTAGGGAATGATCGTA TTGCTTTTGTTTCTAAAAAAGACACAAAACATTCAGCTTTAATTACTGAGTTTGGTAATGGGGATTTGAG CTACACTCTCAAAGATTATGGGAAAAAAGCAGATAAAGCTTTAGATAGGGAGAAAAATGTCACTCTTCAA GGTAACCTAAAACATGATGGCGTGATGTTTGTTGATTATTCTAATTTCAAATACACCAACGCCTCCAAGA ATCCCAATAAGGGTGTAGGCGTTACGAATGGCGTTTCCCATTTAGAAGCAGGCTTTAGCAAGGTAGCTGT CTTTAATTTGCCTGATTTAAATAATCTCGCTATCACTAGTTTAGTAAGGCGGGATTTAGAGGATAAACTA ATCGCTAAAGGATTGTCCCCACAAGAAACTAATAAGCTTGTCAAAGATTTTTTGAGCAGCAACAAAGAAT TGGTTGGAAAAGCTTTAAACTTCAATAAAGCTGTAGCTGAAGCTAAAAACACAGGCAACTATGATGAAGT GAAACAAGCTCAGAAAGATCTTGAAAAATCTCTAAAGAAACGAGAGCGTTTGGAGAAAGAAGTAGCGAAA AAATTGGAGAGCAAAAGCGGCAACAAAAACAAAATGGAAGCAAAATCTCAAGCTAACAGCCAAAAAGATG AGATTTTTGCGTTGATCAATAAAGAGGCTAATAGGGAGGCAAGAGCAATCACTTACGCTCAAAATCTTAA AGGCATCAAAAGGGAATTGTCTGATAAACTTGAGAATGTCAACAAAAATTTGAAAGACTTTAGTAAATCT TTTGATGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGTCAGAAGAAACACTAAAAGCCCTTAAAG GCTCGGTGAAAGATTTAGGTATCAATCCAGAATGGATTTCAAAAGTTGAAAACCTTAATGCAGCTTTGAA TGAATTCAAAAATGGCAAAAATAAGGATTTCAGCAAGGTAACGCAAGCAAAAAGCGACCTTGAAAATTCC GTTAAAGATGTGATCATCAATCAAAAGGTAACGGATAAAGTTGACAATCTCAATCAAGCGGTATCAGTGG CTAAAGCAACGGGTGATTTCAGTAGGGTAGAGCAAGCGTTAGCCGATCTCAAAAACTTCTCAAAGGAGCA ATTGGCTCAACAAGCTCAAAAAAATGAAGATTTCAATACTGGAAAAAATTCTGCACTATACCAATCCGTT AAGAATGGTGTGAATGGAACCCTAGTCGGTAATGGGTTATCTAAAGCAGAAGCCACAACTCTTTCTAAAA ACTTTTCGGACATCAAGAAAGAGTTGAATGCAAAACTTGGAAATTTCAATAACAATAACAATAATGGACT CAAAAACAGCACAGAACCCATTTATGCTAAAGTTAATAAAAAGAAAGCAGGGCAAGCAGCTAGCCCTGAA GAACCCATTTACGCTCAAGTTGCTAAAAAGGTAAATGCAAAAATTGACCGACTCAATCAAATAGCAAGTG GTTTGGGTGTTGTAGGGCAAGCAGTGGGCTTCCCTTTGAAAAGGCATGATAAAGTTGGTGATCTCAGTAA GGTAGGGCAATCAGTTAGCCCTGAACCCATTTATGCTACGATTGATGATCTCGGCGGACCTTTCCCTTTG AAAAGGCATGATAAAGTTGGTGATCTCAGTAAGGTAGGGCTTTCAGTTAGCCCTGAACCCATTTATGCTA CGATTGATGATCTCGGCGGACCTTTCCCTTTGAAAAGGCATGATAAAGTTGGTGATCTCAGTAAGGTAGG GCTTTCAAGGGAGCAACAATTGAAACAGAAGATTGACAATCTCAGTCAAGCGGTATCAGAAGCTAAAGCA GGTTTTTTTGGCAATCTAGAACAAACGATAGACAATCTCAAAGATTCTGCAAAAAACAATCCTGTGAGTC TATGGGCTGAAGGTGCAAAAAAAGTGCCTGCTAGTTTGTCAGCGAAACTAGACAATTACGCTACTAACAG CCACACACGCATTAATAGCAATATCCAAAGTGGAGCAATCAATGAAAAAGCGACCGGTATGCTAACGCAA AAAAACCCTGAGTGGCTCAAGCTCGTGAATGATAAGATCGTTGCGCATAATGTAGGAAGCGTTCCTTTGT TAGAGTATGATAAAATTGGCTTCAACCAGAAGAGTATGAAAGATTATTCTGATTCGTTCAAGTTTTCCAC CGAGTTGAACAATGCTGTAAAAGATGTTAAGTCTGGCTTTACGCAATTTTTAGCCAATGCATTTTCTACA GGATATTACCGCTTGGCGGGAGAAAATGCAGAGCATGGAATCAAAAATGTTAATACAAAAGGTGGTTCCA AAAATCTTAAAGGATTAAGGAATACCAAAAACGCAAAAACCACCCCTTGCTAA |
| Reference |
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(9) Bagnoli F; Buti L; Tompkins L; Covacci A; Amieva MR (2005). Helicobacter pylori CagA induces a transition from polarized to invasive phenotypes in MDCK cells. Proc Natl Acad Sci U S A. 102(45):16339-44. [PudMed:16258069]
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(11) Stein M; Bagnoli F; Halenbeck R; Rappuoli R; Fantl WJ; Covacci A (2002). c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs. Mol Microbiol. 43(4):971-80. [PudMed:11929545]
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| experimental literature |