| Effector Protein ID: 146319636 |
 T4SS name [ID] | Tra_Tn [655] |
| Gene symbol | - |
| Locus tag | SSU05_1982 |
| Strain | Streptococcus suis 05ZYH33 |
| Replicon | chromosome [GenBank: NC_009442] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 1887131..1892209 [-] |
| Product | subtilisin-like serine protease |
| Effector type | Protein |
| Descripton | SspA-1 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | SspA-1 is an effector of T4SS and enhances the virulence of S. suis 2 by triggering an excessive inflammatory response, thereby contrib uting to the development of STSS. |
| UniProt ID | A4VXV9 |
| KEGG ID | ssu:SSU05_1982 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 1692 a.a. [Download] |
| >gi|146319636|ref|YP_001199348.1| subtilisin-like serine protease [Streptococcus suis 05ZYH33] MKQKWSQIENKQRFSIKKLSVGVASVSIGFFITGVPMVQADTSGEGLESTVAVATDMDSRQNSAVEKKED GPLSDDPVKTEQVDEPVAEEGVVEEVVDTEAGEESGLLTDQAATEIETTAGKTTDESKEKEDISGNEASA PQTIPQESQLEPEEVTTGRYILQFSEENRNLVLDKLKKIDGVKIVHEYKEVLTGASVEVGKESLSDVKAI TELTSLEESRRIRPTLHTAKQLVGALKASSKYQTDGRGMVIAVIDSGLDIKHKDMRLDDGVIPKIKDITP STTGTYTLKVPHGYNYVSGNDNLYDDTHEPHGMHIAGTLAGNATDEEVASKKGVDGIAPNAQLLVYKIFS NDPKNYKAETEDAAYAAIEDAIKHGADVISLSVGYYDSGLPGNAYYTIAKRAAEKGIIITAAIGNAGASS SDTSFDLHTNNALGAVDTATTVGVAATPAVIAVGSARNTHLVQREFMLNGQSFGYYPIGYTTLTEGKYEF VDAGNGHWEEVQGLDLAGKVAVIKKDKFDLKDAVRNLKFKDVAGIIVINTDQGWNKDYYRTHQLLVDDKT LLSYSSIWGISLSGEDGRRLLEVANQSQGNTGLVLKPTIGMKKLIEVPTVSGFSSWGPTVNLELKPEIVA PGEDVYATLNDNRYGSMSGTSMASPIVAGASALLLPRIRQMTPPEGMTRMDLLRIILMNTATPLVDVLDS SGHALENSPRQQGAGLLQIDRAFETDVILHHRLKGGVELKEIGRETEFEVTLENLGNQQRSFAISAGKVL TSQDVPVDRIGRSGKVVKEIHATEIKGSSIHLSEQSIQLGPKEKRTIRLKLDAGEAKDQFAEGYIYFKSL TEGQSDISIPYFGFVGDWSKERIVDAPAWETSSKLKLTSVLSSYKHNKSGRYIELGREKIQDNQSPLNPD NIAIQNQHSDSQIGNAFVRFALLRDITNYDLDIVKEATEDAPVLRRIDTGTMLSRVRYVDYFESLSEYSK LRTPIELHRWDGKVYDASNDENIPAPEGQYFFRLRVKNKENGAYQYTYLPVKIDNQKPEIVAIDTNRLSS HRELVVTAKDNNKVWEVRANLNGEDLLVEKVVDDAGQLHYHLKEVELPLDAKNHLRVEVMDIAGNVVAVE KDLMAPVIQFKNLEDLMAIRSKKTVEIKANVSAQVSDVQANLDAQAVNYSLENGQLSLQIPEQSDGRHSF ELILKDKDGNLIYTKTLNYLVDNEKPTIDLDIEKDEEDEEVIQIGKNGRFTLKGKVSDNVSLPKDIKLYY SNLDIGKGERKIIDVKEDGSFEQDFFKSDFPRAIMLTAVDEKGNKLKDLRINTSPESLDEEEETEVPITV NNWLIDPIRFNKESLGRELDSGLVDFKKQEDGTYLFTFEIEAETEQAHSVRINGGEKRYFEDGKLTYPVT LIEEGNVVDISVYNEADELTYTKKYQMLVDTENPVLQLENEVLPLERQVVDSEEDEDEENQYAGVLLADA DGHLTLTGSAKDNGIYWSLKINEDFVARGGFWRQYGNNEKAFRYELHSLKDGDTVKLDLSDSFGNAVVKK YKVRLNDKEVSEQVPEKDLHVERSDKDQTPSIPILKSEAHIPMPKEENSLAPQTGSTEIALLTGDTREDG VEHLGKLTKHEEPLGISDERIEVSVPHREFFERSGIGETGALAADTSGKLPQTGDSLGSVFISTLLGLFG GAMALGNLKRKE |
| - |
| Nucleotide Sequence: 5079 bp [Download] |
| >gi|146317663|ref|NC_009442.1|:c1892209-1887131 Streptococcus suis 05ZYH33 chromosome, complete genome ATGAAACAGAAGTGGTCTCAGATTGAGAATAAACAACGCTTTAGTATCAAGAAGTTAAGTGTCGGTGTGG CATCGGTATCAATAGGATTTTTTATCACGGGTGTTCCGATGGTTCAAGCAGATACTAGTGGAGAAGGATT GGAGTCTACAGTTGCGGTCGCAACAGATATGGATAGTAGGCAAAATTCTGCGGTAGAGAAAAAAGAAGAT GGACCATTATCAGATGATCCAGTTAAAACGGAGCAGGTGGATGAACCAGTTGCTGAAGAGGGAGTGGTCG AAGAAGTTGTAGATACAGAGGCGGGTGAAGAATCAGGTCTTCTCACAGATCAAGCTGCGACCGAGATAGA AACTACAGCTGGTAAGACAACAGATGAGTCAAAGGAAAAAGAAGACATTAGCGGAAACGAAGCTAGTGCT CCTCAAACAATCCCGCAGGAATCACAGCTTGAGCCAGAAGAGGTGACAACAGGGCGCTATATTTTACAAT TTTCCGAAGAGAACCGAAATCTTGTATTGGATAAATTAAAGAAAATTGATGGCGTTAAAATTGTTCATGA GTATAAGGAGGTTTTAACGGGAGCATCAGTAGAGGTAGGGAAAGAAAGTTTGTCTGATGTGAAGGCAATT ACCGAATTAACCTCTTTAGAAGAGAGTCGCCGTATCCGACCGACTCTTCATACTGCTAAACAGCTGGTTG GTGCCTTAAAAGCAAGTTCTAAATATCAGACAGATGGTCGCGGAATGGTGATTGCAGTCATTGACTCCGG TTTGGATATTAAGCACAAAGACATGAGGTTGGATGATGGTGTCATTCCTAAAATTAAGGACATTACTCCA TCTACGACAGGGACATACACATTGAAAGTTCCCCATGGCTATAATTATGTATCTGGCAACGATAATCTCT ACGATGATACCCACGAACCACATGGTATGCACATAGCAGGAACTCTGGCTGGAAATGCAACAGACGAAGA AGTTGCGTCTAAAAAGGGAGTTGATGGGATTGCTCCCAACGCACAACTGCTAGTCTACAAGATTTTTTCA AATGACCCTAAAAATTATAAAGCTGAGACGGAGGATGCTGCTTATGCTGCTATTGAAGATGCTATCAAAC ACGGGGCAGATGTCATCAGCTTGAGTGTTGGTTATTATGATAGCGGGCTACCAGGGAATGCTTACTACAC GATTGCTAAGAGGGCAGCAGAAAAGGGAATTATCATTACAGCGGCTATTGGTAATGCTGGTGCCTCCTCT TCAGACACCTCCTTTGACCTGCATACAAATAATGCCTTAGGAGCTGTGGATACGGCAACAACAGTTGGTG TAGCAGCGACTCCCGCAGTTATCGCGGTTGGTTCGGCGAGAAATACCCATCTTGTTCAACGAGAATTTAT GCTGAATGGACAGTCTTTTGGTTACTATCCTATTGGCTATACAACGCTTACAGAGGGAAAATATGAATTT GTAGATGCTGGAAATGGTCATTGGGAAGAAGTGCAAGGGCTTGATTTGGCTGGTAAAGTAGCGGTTATCA AAAAAGATAAGTTTGACTTGAAAGATGCTGTTCGTAATTTGAAATTCAAGGATGTTGCTGGAATTATTGT GATAAATACTGATCAGGGATGGAACAAGGATTATTATAGGACCCATCAGTTGTTGGTAGATGATAAGACT TTGCTTTCCTACTCCTCTATCTGGGGAATTAGTCTTAGCGGGGAAGATGGAAGGCGATTATTAGAAGTTG CCAACCAATCGCAAGGCAACACTGGTTTGGTTCTTAAACCTACAATTGGAATGAAGAAGTTGATTGAAGT GCCGACTGTATCAGGCTTTTCTAGTTGGGGACCTACGGTCAACTTAGAATTGAAGCCAGAGATTGTGGCG CCGGGAGAGGATGTTTATGCAACCTTGAATGACAATCGTTATGGCTCCATGTCAGGGACTTCGATGGCTT CGCCAATTGTGGCGGGTGCCAGCGCACTTTTATTGCCACGGATTCGCCAAATGACACCACCAGAAGGCAT GACTAGGATGGATTTGCTGAGAATCATTTTGATGAATACTGCTACCCCTTTGGTTGATGTTCTAGATTCA TCTGGGCATGCTTTGGAAAATTCTCCGAGACAACAAGGTGCTGGTCTGTTGCAGATTGATAGAGCCTTTG AAACAGATGTGATTCTTCACCACCGTCTAAAAGGAGGGGTGGAATTAAAAGAAATAGGGCGTGAGACAGA ATTTGAGGTAACCTTGGAAAATCTGGGAAACCAACAAAGAAGCTTTGCTATTTCAGCTGGGAAAGTGTTG ACTAGTCAAGATGTTCCTGTTGATAGAATAGGACGTTCTGGAAAAGTAGTTAAAGAGATTCATGCGACAG AAATCAAGGGGTCGAGTATTCATCTTTCTGAGCAATCCATTCAACTAGGTCCAAAAGAGAAGAGAACCAT TCGCCTGAAATTGGATGCAGGAGAAGCGAAAGACCAGTTTGCAGAAGGGTATATTTACTTCAAATCATTG ACGGAGGGGCAGTCTGACATCAGCATACCTTATTTTGGCTTTGTTGGTGACTGGTCAAAAGAAAGGATTG TTGATGCACCGGCTTGGGAAACCAGTTCTAAATTGAAACTGACCTCAGTTTTATCTAGCTATAAACACAA TAAGTCTGGGCGCTATATTGAACTTGGGCGTGAAAAGATTCAAGATAATCAATCGCCTCTCAATCCAGAC AATATCGCAATTCAAAACCAGCATTCGGACAGTCAGATTGGGAATGCCTTTGTTCGATTTGCGCTATTGA GGGATATTACCAACTATGATTTGGATATTGTAAAAGAAGCTACAGAAGATGCTCCTGTTTTAAGGCGAAT TGATACAGGAACCATGCTGTCTCGTGTTCGCTATGTAGATTATTTTGAAAGTCTATCGGAGTATTCCAAG CTTCGTACTCCGATAGAATTGCACCGTTGGGATGGGAAAGTGTACGATGCAAGCAATGATGAAAATATAC CAGCACCGGAAGGACAATATTTCTTTAGATTGCGGGTAAAAAATAAAGAAAATGGGGCCTATCAGTATAC CTATCTGCCAGTCAAAATTGATAATCAAAAGCCAGAGATTGTCGCGATTGATACCAATCGTCTATCCAGC CATAGAGAACTGGTCGTCACAGCCAAGGATAATAATAAAGTTTGGGAGGTTCGAGCTAATCTAAATGGAG AAGATCTTCTTGTTGAAAAGGTTGTAGATGATGCAGGTCAACTACATTACCATCTCAAAGAAGTGGAACT GCCACTCGATGCTAAAAATCATCTCCGTGTTGAGGTGATGGATATAGCGGGTAATGTGGTTGCTGTTGAA AAAGATTTGATGGCGCCTGTAATCCAGTTTAAAAATTTGGAAGATTTGATGGCAATTCGCAGTAAGAAAA CTGTAGAAATTAAAGCGAACGTCTCAGCGCAAGTTTCCGATGTACAGGCTAACTTGGATGCTCAGGCTGT GAATTACTCTCTTGAGAATGGTCAACTATCTCTCCAGATTCCAGAGCAATCAGATGGACGTCATAGTTTT GAATTAATCTTGAAAGATAAGGATGGCAACCTTATTTACACTAAAACCTTGAATTATTTGGTAGATAATG AAAAGCCGACGATTGATCTTGATATTGAAAAAGATGAAGAGGATGAAGAGGTTATCCAGATTGGTAAAAA TGGGCGTTTTACATTGAAAGGGAAAGTGAGTGATAATGTTAGTCTTCCTAAGGACATCAAACTTTACTAT TCCAATCTAGACATTGGTAAGGGAGAGCGGAAAATCATAGATGTAAAAGAAGACGGCAGTTTTGAGCAAG ACTTCTTTAAATCTGATTTTCCTAGAGCCATCATGTTAACTGCGGTAGATGAGAAGGGAAATAAATTAAA GGACCTTCGTATCAATACAAGTCCAGAGAGTCTGGATGAGGAGGAGGAAACAGAAGTTCCGATTACTGTC AATAACTGGCTGATTGACCCAATTCGTTTCAATAAAGAAAGTCTTGGTCGTGAGCTAGATAGCGGGTTGG TCGACTTCAAAAAGCAAGAAGATGGGACTTATCTATTTACATTTGAAATAGAAGCAGAAACCGAACAAGC TCATTCTGTGCGCATCAATGGTGGTGAAAAACGCTATTTTGAGGATGGGAAGTTGACCTATCCAGTTACT CTGATTGAAGAGGGAAATGTTGTGGATATAAGTGTGTACAATGAGGCAGATGAGTTGACTTACACGAAGA AATATCAGATGTTGGTTGATACAGAAAACCCTGTTTTACAGCTGGAAAATGAGGTGCTACCATTGGAAAG ACAGGTAGTGGATAGTGAAGAAGATGAAGACGAGGAAAATCAGTATGCAGGAGTCCTCCTGGCAGATGCT GATGGGCACTTGACACTTACCGGAAGCGCCAAGGATAATGGAATTTATTGGTCCTTGAAGATCAACGAAG ATTTTGTAGCTCGAGGAGGCTTCTGGAGGCAGTATGGAAATAATGAAAAAGCCTTTCGCTATGAGCTACA TAGTCTGAAAGACGGGGATACAGTCAAACTTGATTTGAGTGACAGTTTTGGAAATGCTGTTGTGAAGAAA TATAAGGTACGGTTAAATGACAAGGAAGTATCTGAGCAGGTTCCTGAAAAAGACCTTCATGTGGAGCGAT CAGATAAGGATCAAACCCCTAGCATTCCTATTCTGAAATCGGAAGCGCATATACCAATGCCAAAAGAAGA GAATTCACTTGCTCCGCAAACAGGATCCACTGAAATCGCGCTGTTAACTGGCGATACAAGAGAAGATGGT GTGGAGCATTTGGGGAAACTTACAAAACATGAGGAGCCACTAGGAATTTCTGACGAGAGAATAGAAGTGT CCGTACCTCACAGAGAATTCTTTGAAAGAAGCGGAATAGGAGAGACAGGTGCATTAGCGGCGGATACTAG TGGGAAACTGCCTCAAACTGGGGATAGCCTGGGAAGTGTCTTTATAAGTACTTTGTTAGGTCTATTTGGT GGAGCTATGGCCCTCGGAAATTTGAAGCGAAAAGAATAG |
| Reference |
(1) Yin S et al. (2016). Subtilisin-like protease-1 secreted through type IV secretion system contributes to high virulence of Streptococcus suis 2. Sci Rep. 6:27369. [PudMed:27270879] 
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| experimental literature |