 T4SS ID | 11 |
| Strain | Helicobacter pylori 26695 |
| Replicon | chromosome [Browse all T4SS(s) in this replicon] |
| Accession | NC_000915 |
| Location | 13702..16611; 36556..40581 |
| Name | ComB |
| Function | DNA uptake |
| Classification | Type IVA; Type P |
 Experimental investigation has been performed on this T4SS. | |
Information of structure: 
T4SS components |
| Component | ComB2 | ComB3 | ComB4 | ComB6 | ComB7 | ComB8 | ComB9 | ComB10 |
| Number | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 2 |
The information of T4SS components from NC_000915 | ||||||
| Region 1: 13702..16611 | ||||||
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| # | Locus tag (Gene) | Coordinates [+/-], size (bp) | Protein GI | Product | Component | |
| 1 | HP0011 (groES) | 9268..9624 [-], 357 | 15644644 | co-chaperonin GroES | ||
| 2 | HP0012 (dnaG) | 9911..11590 [+], 1680 | 15644645 | DNA primase | ||
| 3 | HP0013 | 11587..12639 [+], 1053 | 15644646 | hypothetical protein | ||
| 4 | HP0014 | 12728..13555 [+], 828 | 15644647 | hypothetical protein | ||
| 5 | HP0015 | 13702..13983 [+], 282 | 15644648 | hypothetical protein | ComB2 | |
| 6 | HP0016 | 13983..14246 [+], 264 | 15644649 | hypothetical protein | ComB3 | |
| 7 | HP0017 | 14248..16611 [+], 2364 | 15644650 | protein VirB4 | ComB4 | |
| 8 | HP0018 | 16863..18272 [+], 1410 | 15644651 | hypothetical protein | ||
| 9 | HP0019 | 18380..19345 [+], 966 | 15644652 | chemotaxis protein (cheV) | ||
| 10 | HP0020 | 19342..20559 [+], 1218 | 15644653 | carboxynorspermidine decarboxylase (nspC) | ||
| 11 | HP0021 | 20569..21141 [-], 573 | 15644654 | lipid A 1-phosphatase | ||
| Region 2: 36556..40581 | ||||||
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| # | Locus tag (Gene) | Coordinates [+/-], size (bp) | Protein GI | Product | Component | |
| 1 | HP0031 | 31961..32374 [+], 414 | 15644664 | hypothetical protein | ||
| 2 | HP0032 | 32405..32680 [+], 276 | 15644665 | hypothetical protein | ||
| 3 | HP0033 | 32680..34905 [+], 2226 | 15644666 | ATP-dependent C1p protease (clpA) | ||
| 4 | HP0034 | 34895..35248 [+], 354 | 15644667 | aspartate alpha-decarboxylase | ||
| 5 | HP0035 | 35251..35544 [+], 294 | 15644668 | hypothetical protein | ||
| 6 | HP0036 | 35544..36548 [+], 1005 | 15644669 | hypothetical protein | ||
| 7 | HP0037 | 36556..37611 [+], 1056 | 15644670 | NADH-ubiquinone oxidoreductase subunit | ComB6 | |
| 8 | HP0038 | 37738..38475 [+], 738 | 15644671 | hypothetical protein | ComB8 | |
| 9 | HP0039m | 38472..39453 [+], 982 | 15646206 | conjugal plasmid transfer system protein | ComB9 | |
| 10 | HP0041 | 39446..39817 [+], 372 | 15644672 | hypothetical protein | ComB10 | |
| 11 | HP0042 | 39880..40581 [+], 702 | 15644673 | trbI protein | ComB10 | |
| 12 | HP0043 | 40651..42063 [+], 1413 | 15644674 | mannose-6-phosphate isomerase | ||
| 13 | HP0044 | 42105..43250 [+], 1146 | 15644675 | GDP-D-mannose dehydratase | ||
| 14 | HP0045 | 43243..44175 [+], 933 | 15644676 | nodulation protein (nolK) | ||
| 15 | HP0046 | 44299..44436 [+], 138 | 15644677 | hypothetical protein | ||
 Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any. |
Download FASTA format files |
| Proteins Genes |
| # | Name | Image | Resource | Detail | Reference |
| 1 | ComB10 |  | PDB (2BHV) | Structure of ComB10 of the Com Type IV secretion system of Helicobacter pylori. | (1) PubMed: 15764702 |
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(1) Terradot L; Bayliss R; Oomen C; Leonard GA; Baron C; Waksman G (2005). Structures of two core subunits of the bacterial type IV secretion system, VirB8 from Brucella suis and ComB10 from Helicobacter pylori. Proc Natl Acad Sci U S A. 102(12):4596-601. [PudMed:15764702]
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(1) Fischer W; Windhager L; Rohrer S; Zeiller M; Karnholz A; Hoffmann R; Zimmer R; Haas R (2010). Strain-specific genes of Helicobacter pylori: genome evolution driven by a novel type IV secretion system and genomic island transfer. Nucleic Acids Res. 38(18):6089-101. [PudMed:20478826] 
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(2) Stingl K; Muller S; Scheidgen-Kleyboldt G; Clausen M; Maier B (2010). Composite system mediates two-step DNA uptake into Helicobacter pylori. Proc Natl Acad Sci U S A. 107(3):1184-9. [PudMed:20080542]
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(3) Oyarzabal OA; Rad R; Backert S (2007). Conjugative transfer of chromosomally encoded antibiotic resistance from Helicobacter pylori to Campylobacter jejuni. J Clin Microbiol. 45(2):402-8. [PudMed:17135441]
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(4) Karnholz A; Hoefler C; Odenbreit S; Fischer W; Hofreuter D; Haas R (2006). Functional and topological characterization of novel components of the comB DNA transformation competence system in Helicobacter pylori. J Bacteriol. 188(3):882-93. [PudMed:16428391]
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(5) Backert S; Kwok T; Konig W (2005). Conjugative plasmid DNA transfer in Helicobacter pylori mediated by chromosomally encoded relaxase and TraG-like proteins. Microbiology. 151(Pt 11):3493-503. [PudMed:16272373]
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(6) Terradot L; Bayliss R; Oomen C; Leonard GA; Baron C; Waksman G (2005). Structures of two core subunits of the bacterial type IV secretion system, VirB8 from Brucella suis and ComB10 from Helicobacter pylori. Proc Natl Acad Sci U S A. 102(12):4596-601. [PudMed:15764702]
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(7) Hofreuter D; Karnholz A; Haas R (2003). Topology and membrane interaction of Helicobacter pylori ComB proteins involved in natural transformation competence. Int J Med Microbiol. 293(2-3):153-65. [PudMed:12868652]
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(8) Hofreuter D; Odenbreit S; Haas R (2001). Natural transformation competence in Helicobacter pylori is mediated by the basic components of a type IV secretion system. Mol Microbiol. 41(2):379-91. [PudMed:11489125]
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| This literature contains experimental investigation |
| This literature contains bioinformatics investigation |