I. Information of IME
ICEberg ID230_IME
Name SGI1-V This IME is derived from experimental literature
OrganismProteus mirabilis VB1248
Size (bp)42922 bp
GC content [Genome] (%)
Insertion site3'-end of the trmE
FunctionaacA4 (kanamycin, tobramycin, netilmicin, amikacin), aadB (kanamycin, gentamicin, tobramycin), dhfrA1 (trimethoprim), blaVEB-6(extended-spectrum cephalosporin), sul1 (sulfonamides), qnrA1 (quinolones)
Species that IME can be transferred toEnterobacter aerogenes 409-S1A1
Nucleotide SequenceHQ888851 (complete IME sequence in this contig)
Putative oriT region -
Putative relaxase -

II. IME interaction with ICE/CIME/Plasmids

The Interaction Network among ICE/IME/CIME/plasmid

Detailed Informatioin of the Interaction Network
# IME  Inter_Ele [Type] Methods Donors Recipients Exper_Ref 
1SGI1-V pA/C2 [IncA/C plasmid] experimentalin trans Proteus mirabilis ESC Enterobacter aerogenes 409-S1A1 27150396

experimental This is an interactioin derived from experimental literature

The graph information of SGI1-V components from HQ888851
Complete gene list of SGI1-V from HQ888851
#GeneCoordinates [+/-], size (bp) Product *Reannotation 
1thdF1..468 [+], 468tRNA modification GTPase
2int672..1889 [+], 1218integrase
3xis1886..2254 [-], 369excisionase
4rep2612..3565 [-], 954replication protein
5-3552..3842 [-], 291hypothetical protein
6-3930..6689 [-], 2760conjugal transfer mating pair stabilization protein TraNTraN_F, T4SS component 
7-6786..7319 [-], 534putative regulator protein
8-7322..7933 [-], 612hypothetical protein
9-7933..8154 [-], 222hypothetical protein
10-8329..8619 [+], 291hypothetical protein
11-8639..8893 [-], 255hypothetical protein
12-8893..12297 [-], 3405conjugative transfer pilus assembly protein TraGTraG_F, T4SS component 
13-12301..13725 [-], 1425conjugal transfer pilus assembly protein TraHTraH_F, T4SS component 
14-13969..14826 [+], 858hypothetical protein
15-15257..15571 [+], 315hypothetical protein
16-15681..16472 [+], 792hydrolase-like protein
17-16565..16984 [+], 420hypothetical protein
18-17990..18259 [-], 270hypothetical protein
19-18337..18522 [-], 186hypothetical protein
20-18382..18636 [+], 255hypothetical protein
21-18533..18850 [-], 318hypothetical protein
22-19109..19405 [-], 297hypothetical protein
23-19409..20374 [-], 966phage integrase family protein
24-20467..20928 [+], 462S021-like elongation protein
25-20714..20989 [-], 276hypothetical protein
26-21322..23865 [-], 2544subtilisin-like peptidase
27-23886..24875 [-], 990AAA ATPase, central domain protein
28res24945..25529 [-], 585resolvase
29intI125802..26815 [-], 1014IntI1 integraseIntegrase 
30accA427564..28169 [+], 606AacA4 aminoglycoside (6') acetyltransferaseAR 
31aadB28239..28772 [+], 534AadB aminoglycoside (2'') adenylyltransferaseAR 
32dhfrA128841..29314 [+], 474DhfrA1 dihydrofolate reductaseAR 
33-29408..29887 [+], 480hypothetical protein
34qacEdelta130018..30365 [+], 348QacEdelta1
35sul130359..31198 [+], 840Sul1 dihydropteroate synthase
36blaVEB-633148..34047 [-], 900VEB-6 extended-spectrum beta-lactamaseAR 
37qacEdelta134296..34643 [+], 348QacEdelta1
38sul134637..35476 [+], 840dihydropteroate synthaseAR 
39-35881..37422 [+], 1542transposase
40qnrA137773..38429 [+], 657QnrA1 pentapeptide repeat proteinAR 
41-38573..38872 [+], 300hypothetical protein
42-38916..39350 [+], 435hypothetical protein
43qacEdelta139444..39791 [+], 348QacEdelta1
44sul139785..40624 [+], 840dihydropteroate synthaseAR 
45-40752..41252 [+], 501acetyltransferase
46-41276..41563 [+], 288hypothetical protein
47tnpA610041729..42523 [+], 795IS6100 transposase
48-43692..44909 [+], 1218putative phage integrase
49-45303..45521 [+], 219putative transcriptional regulator
50-45562..46089 [+], 528hypothetical protein
51-46093..46776 [-], 684hypothetical protein
52-46780..48033 [-], 1254hypothetical protein
flank Flanking regions
integrase Gene may contribute to site-specific recombination
conjugation Gene may play role in conjugative transfer
virulence  Gene may be involved in adaptative function

ElementNo. of sequencesDownload
Nucleotide sequences1Fasta
(1) Guedon G; Libante V; Coluzzi C; Payot S; Leblond-Bourget N (2017). The Obscure World of Integrative and Mobilizable Elements, Highly Widespread Elements that Pirate Bacterial Conjugative Systems. Genes (Basel). 8(11). [PudMed:29165361]
(2) Siebor E; de Curraize C; Amoureux L; Neuwirth C (2016). Mobilization of the Salmonella genomic island SGI1 and the Proteus genomic island PGI1 by the A/C2 plasmid carrying blaTEM-24 harboured by various clinical species of Enterobacteriaceae. J Antimicrob Chemother. 71(8):2167-70. [PudMed:27150396]
(3) Siebor E; Neuwirth C (2011). The new variant of Salmonella genomic island 1 (SGI1-V) from a Proteus mirabilis French clinical isolate harbours blaVEB-6 and qnrA1 in the multiple antibiotic resistance region. J Antimicrob Chemother. 66(11):2513-20. [PudMed:21846670]