 ICEberg ID | 212_IME |
Name  | SGI1-I  |
| Family | - |
| Organism | Proteus mirabilis Pm107 |
| Size (bp) | 42477 bp |
| GC content [Genome] (%) | |
| Insertion site | 3'-end of the trmE |
| Function | aadA2, floR, tet(G), dfrA1, sul1 |
| Species that IME can be transferred to | Escherichia coli UB1637 |
| Nucleotide Sequence | KJ186152; KU563154 (complete IME sequence in this contig) |
| Replicon | - |
| Coordinates | 145..42621 |
| Putative oriT region | - |
| Putative relaxase | - |
The Interaction Network among ICE/IME/CIME/plasmid | ||||||
 | ||||||
| Detailed Informatioin of the Interaction Network | ||||||
| # | IME | Inter_Ele [Type] | Methods | Donors | Recipients | Exper_Ref |
| 1 | SGI1-I | pRMH760 [IncC plasmid] | in trans | Salmonella enterica | Escherichia coli | 27620651 |
| This is an interactioin derived from experimental literature |
The graph information of SGI1-I components from KJ186152 | |||||
 | |||||
| Complete gene list of SGI1-I from KJ186152 | |||||
| # | Gene | Coordinates [+/-], size (bp) | Product | *Reannotation | |
| 1 | thdF | 1..162 [+], 162 | tRNA modification GTPase | ||
| 2 | int | 366..1583 [+], 1218 | integrase | ||
| 3 | xis | 1580..1948 [-], 369 | excisionase | ||
| 4 | rep | 2306..3259 [-], 954 | replication protein | ||
| 5 | - | 3246..3536 [-], 291 | hypothetical protein | ||
| 6 | - | 3624..6383 [-], 2760 | putative mating pair stabilization protein | TraN_F, T4SS component | |
| 7 | - | 6480..7013 [-], 534 | putative regulator protein | ||
| 8 | - | 7016..7627 [-], 612 | hypothetical protein | ||
| 9 | - | 7627..7848 [-], 222 | hypothetical protein | ||
| 10 | - | 8023..8313 [+], 291 | hypothetical protein | ||
| 11 | - | 8333..8587 [-], 255 | hypothetical protein | ||
| 12 | - | 8587..11991 [-], 3405 | putative pilus assembly protein | TraG_F, T4SS component | |
| 13 | - | 11995..13419 [-], 1425 | putative pilus assembly protein | TraH_F, T4SS component | |
| 14 | - | 13663..14520 [+], 858 | hypothetical protein | ||
| 15 | - | 14517..14912 [+], 396 | hypothetical protein | ||
| 16 | - | 15327..15596 [-], 270 | hypothetical protein | ||
| 17 | - | 15674..15859 [-], 186 | hypothetical protein | ||
| 18 | - | 15719..15973 [+], 255 | hypothetical protein | ||
| 19 | - | 15870..16187 [-], 318 | hypothetical protein | ||
| 20 | - | 16445..16741 [-], 297 | hypothetical protein | ||
| 21 | - | 16745..17710 [-], 966 | putative integrase | ||
| 22 | - | 17803..18138 [+], 336 | hypothetical protein | ||
| 23 | - | 18050..18325 [-], 276 | hypothetical protein | ||
| 24 | - | 18686..20326 [-], 1641 | putative helicase | ||
| 25 | - | 20344..22269 [-], 1926 | putative exonuclease | ||
| 26 | - | 22347..24890 [-], 2544 | putative subtilisin proteinase-like protein | ||
| 27 | - | 24911..25900 [-], 990 | putative ATPase | ||
| 28 | res | 25979..26563 [-], 585 | resolvase | ||
| 29 | intI1 | 26837..27850 [-], 1014 | integrase | Integrase | |
| 30 | aadA2 | 27996..28787 [+], 792 | streptomycin/spectinomycin resistance protein | AR | |
| 31 | qacEdelta1 | 28951..29298 [+], 348 | quaternary ammonium compound and disinfectant protein | ||
| 32 | - | 29292..30263 [+], 972 | sul1delta fusion protein | AR | |
| 33 | flo | 30480..31694 [+], 1215 | chloramphenicol and florfenicol resistance protein | AR | |
| 34 | tetR | 31901..32527 [-], 627 | tetracycline resistance regulator protein | ||
| 35 | tet(G) | 32679..33806 [+], 1128 | tetracycline resistance protein | AR | |
| 36 | - | 33827..34618 [+], 792 | putative LysR-type transcriptional regulator | ||
| 37 | - | 34710..36194 [-], 1485 | putative transposase-like protein | ||
| 38 | groEL/intI1 | 36469..37122 [-], 654 | GroEL/integrase fusion protein | ||
| 39 | dfrA1 | 37279..37752 [+], 474 | dihydrofolate reductase I | AR | |
| 40 | - | 37846..38325 [+], 480 | OrfC | ||
| 41 | qacEdelta1 | 38456..38803 [+], 348 | quaternary ammonium compound and disinfectant protein | ||
| 42 | sul1 | 38797..39636 [+], 840 | sulfonamide resistance protein | AR | |
| 43 | - | 39764..40264 [+], 501 | putative acetyltransferase | ||
| 44 | - | 40288..40575 [+], 288 | hypothetical protein | ||
| 45 | tnpA | 40741..41535 [+], 795 | transposase | ||
| 46 | - | 41883..42512 [+], 630 | hypothetical protein | ||
| 47 | hipB | 42788..43045 [+], 258 | transcriptional regulator | ||
| 48 | hipA | 43046..44359 [+], 1314 | regulatory protein | ||
| 49 | - | 44762..45204 [+], 443 | membrane protein | ||
The graph information of SGI1-I components from KU563154 | |||||
 | |||||
| Complete gene list of SGI1-I from KU563154 | |||||
| # | Gene | Coordinates [+/-], size (bp) | Product | *Reannotation | |
| 1 | trmE | 201..917 [+], 717 | TrmE | ||
| 2 | intSGI1-I | 1121..2338 [+], 1218 | IntSGI1-I | ||
| 3 | - | 2335..2703 [-], 369 | hypothetical protein | ||
| 4 | rep | 3061..4014 [-], 954 | Rep | ||
| 5 | - | 4001..4291 [-], 291 | hypothetical protein | ||
| 6 | - | 4379..7138 [-], 2760 | hypothetical protein | TraN_F, T4SS component | |
| 7 | - | 7235..7768 [-], 534 | hypothetical protein | ||
| 8 | - | 7771..8382 [-], 612 | Hypothetical protein | ||
| 9 | - | 8382..8603 [-], 222 | Hypothetical protein | ||
| 10 | - | 8778..9068 [+], 291 | hypothetical protein | ||
| 11 | - | 9088..9342 [-], 255 | hypothetical protein | ||
| 12 | traG | 9342..12746 [-], 3405 | TraG | TraG_F, T4SS component | |
| 13 | traH | 12750..14174 [-], 1425 | TraH | TraH_F, T4SS component | |
| 14 | - | 14418..15275 [+], 858 | hypothetical protein | ||
| 15 | - | 15272..15667 [+], 396 | hypothetical protein | ||
| 16 | - | 16082..16351 [-], 270 | hypothetical protein | ||
| 17 | - | 16429..16614 [-], 186 | hypothetical protein | ||
| 18 | - | 16474..16728 [+], 255 | hypothetical protein | ||
| 19 | - | 16625..16942 [-], 318 | hypothetical protein | ||
| 20 | - | 17200..17496 [-], 297 | hypothetical protein | ||
| 21 | int | 17500..18465 [-], 966 | Int | ||
| 22 | - | 18558..18893 [+], 336 | hypothetical protein | ||
| 23 | - | 18805..19080 [-], 276 | hypothetical protein | ||
| 24 | - | 19441..21081 [-], 1641 | putative helicase | ||
| 25 | - | 21099..23024 [-], 1926 | putative exonuclease | ||
| 26 | - | 23102..25645 [-], 2544 | putative proteinase subtilisin-like protein | ||
| 27 | - | 25666..26655 [-], 990 | putative ATPase | ||
| 28 | resG | 26734..27318 [-], 585 | ResG | ||
| 29 | intI1 | 27592..28605 [-], 1014 | IntI1 integrase | Integrase | |
| 30 | aadA2 | 28763..29542 [+], 780 | AadA2 | AR | |
| 31 | qacEdelta1 | 29706..30053 [+], 348 | QacEdelta1 | ||
| 32 | floR | 31235..32449 [+], 1215 | FloR | AR | |
| 33 | tetR | 32656..33282 [-], 627 | tetR | ||
| 34 | tetA(G) | 33434..34561 [+], 1128 | tetA(G) | AR | |
| 35 | - | 34582..35373 [+], 792 | putative LysR-type transcriptional regulator | ||
| 36 | rcr3 | 35465..36949 [-], 1485 | Rcr3 | ||
| 37 | groEL-int | 37224..37838 [-], 615 | GroEL-Int | ||
| 38 | dfrA1 | 38010..38468 [+], 459 | DfrA1 | AR | |
| 39 | - | 38562..39041 [+], 480 | hypothetical protein | ||
| 40 | qacEdelta1 | 39172..39519 [+], 348 | QacEdelta1 | ||
| 41 | sul1 | 39513..40352 [+], 840 | Sul1 | AR | |
| 42 | - | 40480..40980 [+], 501 | putative acetyltransferase | ||
| 43 | - | 41004..41291 [+], 288 | hypothetical protein | ||
| 44 | - | 41457..42251 [+], 795 | transposase | ||
| 45 | - | 42599..43228 [+], 630 | hypothetical protein | ||
| 46 | yidY | 43538..44725 [+], 1188 | YidY | AR | |
 Flanking regions |
 Gene may contribute to site-specific recombination |
 Gene may play role in conjugative transfer |
 Gene may be involved in adaptative function |
| (1) Soliman AM; Ahmed AM; Shimamoto T; El-Domany RA; Nariya H; Shimamoto T (2017). First report in Africa of two clinical isolates of Proteus mirabilis carrying Salmonella genomic island (SGI1) variants, SGI1-PmABB and SGI1-W. Infect Genet Evol. 51:132-137. [PudMed:28359833] |
| (2) Harmer CJ; Hamidian M; Ambrose SJ; Hall RM (2016). Destabilization of IncA and IncC plasmids by SGI1 and SGI2 type Salmonella genomic islands. Plasmid. 87-88:51-57. [PudMed:27620651] |
| (3) Levings RS; Lightfoot D; Partridge SR; Hall RM; Djordjevic SP (2005). The genomic island SGI1, containing the multiple antibiotic resistance region of Salmonella enterica serovar Typhimurium DT104 or variants of it, is widely distributed in other S. enterica serovars. J Bacteriol. 187(13):4401-9. [PudMed:15968049] |