 ICEberg ID | 204_IME |
Name  | SGI1  |
| Family | - |
| Organism | Salmonella enterica Typhymurium DT104 |
| Size (bp) | 42451 bp |
| GC content [Genome] (%) | |
| Insertion site | 3′ of trmE (tRNA modification GTPase), an intergenic secondary site |
| Function | aadA2, sul1, floR, tetA(G), tetR and blaPSE-1( streptomycin and spectinomycin, sulfonamides, chloramphenicol and florfenicol, tetracyclines, and ampicillin) |
| Species that IME can be transferred to | Citrobacter freundii 2954-S1F1; Enterobacter aerogenes 409-S1A1; Enterobacter cloacae 646-S1L21; Escherichia coli 565-S1C1; Klebsiella oxytoca 603-S1O1; Klebsiella pneumoniae 568-S1K38; Proteus mirabilis 709-S1P13; Proteus vulgaris 835-S1V1; Providencia stuartii 719-S1T1; Serratia marcescens 1003-S1M12 |
| Nucleotide Sequence | AF261825 (complete IME sequence in this contig) |
| Replicon | - |
| Coordinates | 146..42596 |
| Putative oriT region | - |
| Putative relaxase | - |
The Interaction Network among ICE/IME/CIME/plasmid | ||||||
 | ||||||
| Detailed Informatioin of the Interaction Network | ||||||
| # | IME | Inter_Ele [Type] | Methods | Donors | Recipients | Exper_Ref |
| 1 | SGI1 | pR55 [IncA/C plasmid] | in trans | Salmonella enterica | Escherichia coli | 27150396; 21187963 |
| 2 | SGI1 | pR16a [IncA/C plasmid] | in trans | Salmonella enterica | Escherichia coli | 27150396; 21187963 |
| 3 | SGI1 | pRA1 [IncA plasmid] | in trans | Salmonella enterica | Escherichia coli | 27150396; 21187963 |
| This is an interactioin derived from experimental literature |
The graph information of SGI1 components from AF261825 | |||||
 | |||||
| Complete gene list of SGI1 from AF261825 | |||||
| # | Gene | Coordinates [+/-], size (bp) | Product | *Reannotation | |
| 1 | int | 367..1584 [+], 1218 | integrase | ||
| 2 | xis | 1581..1949 [-], 369 | excisionase | ||
| 3 | rep | 2307..3260 [-], 954 | replication protein | ||
| 4 | S004 | 3247..3537 [-], 291 | hypothetical protein | ||
| 5 | S005 | 3625..6384 [-], 2760 | putative mating pair stabilization protein | TraN_F, T4SS component | |
| 6 | S006 | 6481..7014 [-], 534 | putative regulator protein | ||
| 7 | S007 | 7017..7628 [-], 612 | hypothetical protein | ||
| 8 | S008 | 7628..7849 [-], 222 | hypothetical protein | ||
| 9 | S009 | 8024..8314 [+], 291 | hypothetical protein | ||
| 10 | - | 8334..8588 [-], 255 | hypothetical protein | ||
| 11 | S011 | 8588..11992 [-], 3405 | putative pilus assembly protein | TraG_F, T4SS component | |
| 12 | S012 | 11996..13420 [-], 1425 | putative pilus assembly protein | TraH_F, T4SS component | |
| 13 | S013 | 13664..14521 [+], 858 | hypothetical protein | ||
| 14 | S014 | 14518..14913 [+], 396 | hypothetical protein | ||
| 15 | S015 | 15328..15597 [-], 270 | hypothetical protein | ||
| 16 | S016 | 15675..15860 [-], 186 | hypothetical protein | ||
| 17 | S017 | 15720..15974 [+], 255 | hypothetical protein | ||
| 18 | S018 | 15871..16188 [-], 318 | hypothetical protein | ||
| 19 | S019 | 16447..16743 [-], 297 | hypothetical protein | ||
| 20 | S020 | 16747..17712 [-], 966 | putative integrase | ||
| 21 | S021 | 17805..18140 [+], 336 | hypothetical protein | ||
| 22 | S022 | 18052..18327 [-], 276 | hypothetical protein | ||
| 23 | S023 | 18688..20328 [-], 1641 | putative helicase | ||
| 24 | S024 | 20346..22271 [-], 1926 | putative exonuclease | ||
| 25 | S025 | 22349..24892 [-], 2544 | putative subtilisin proteinase-like protein | ||
| 26 | S026 | 24913..25902 [-], 990 | putative ATPase | ||
| 27 | res | 25981..26565 [-], 585 | resolvase | ||
| 28 | intI1 | 26839..27852 [-], 1014 | integrase | Integrase | |
| 29 | aadA2 | 27998..28789 [+], 792 | streptomycin/spectinomycin resistance protein | AR | |
| 30 | qacEdelta1 | 28953..29300 [+], 348 | quaternary ammonium compound and disinfectant protein | ||
| 31 | - | 29294..30265 [+], 972 | sul1delta fusion protein | AR | |
| 32 | flo | 30482..31696 [+], 1215 | chloramphenicol and florfenicol resistance protein | AR | |
| 33 | tetR | 31903..32529 [-], 627 | tetracycline resistance regulator protein | ||
| 34 | tet(G) | 32681..33808 [+], 1128 | tetracycline resistance protein | AR | |
| 35 | qacEdelta1 | 33829..34620 [+], 792 | putative LysR-type transcriptional regulator | ||
| 36 | - | 34712..36196 [-], 1485 | putative transposase-like protein | ||
| 37 | groEL/intI1 | 36471..37124 [-], 654 | GroEL/integrase fusion protein | ||
| 38 | pse-1 | 37330..38196 [+], 867 | beta-lactamase | AR | |
| 39 | qacEdelta1 | 38413..38760 [+], 348 | quaternary ammonium compound and disinfectant protein | ||
| 40 | sul1 | 38754..39593 [+], 840 | sulfonamide resistance protein | AR | |
| 41 | - | 39721..40221 [+], 501 | putative acetyltransferase | ||
| 42 | - | 40245..40532 [+], 288 | hypothetical protein | ||
| 43 | tnpA | 40698..41492 [+], 795 | transposase | ||
| 44 | S044 | 41840..42469 [+], 630 | hypothetical protein | ||
| 45 | urt | 44397..45359 [+], 963 | hypothetical protein | ||
| 46 | rt | 45359..46294 [+], 936 | reverse transcriptase | ||
 Flanking regions |
 Gene may contribute to site-specific recombination |
 Gene may play role in conjugative transfer |
 Gene may be involved in adaptative function |
| (1) Guedon G; Libante V; Coluzzi C; Payot S; Leblond-Bourget N (2017). The Obscure World of Integrative and Mobilizable Elements, Highly Widespread Elements that Pirate Bacterial Conjugative Systems. Genes (Basel). 8(11). [PudMed:29165361] |
| (2) Carraro N; Rivard N; Burrus V; Ceccarelli D (2017). Mobilizable genomic islands, different strategies for the dissemination of multidrug resistance and other adaptive traits. Mob Genet Elements. 7(2):1-6. [PudMed:28439449] |
| (3) Schultz E; Barraud O; Madec JY; Haenni M; Cloeckaert A; Ploy MC; Doublet B (2017). Multidrug Resistance Salmonella Genomic Island 1 in a Morganella morganii subsp. morganii Human Clinical Isolate from France. mSphere. 2(2). [PudMed:28435889] |
| (4) Carraro N; Durand R; Rivard N; Anquetil C; Barrette C; Humbert M; Burrus V (2017). Salmonella genomic island 1 (SGI1) reshapes the mating apparatus of IncC conjugative plasmids to promote self-propagation. PLoS Genet. 13(3):e1006705. [PudMed:28355215] |
| (5) Huguet KT; Gonnet M; Doublet B; Cloeckaert A (2016). A toxin antitoxin system promotes the maintenance of the IncA/C-mobilizable Salmonella Genomic Island 1. Sci Rep. 6:32285. [PudMed:27576575] |
| (6) Siebor E; de Curraize C; Amoureux L; Neuwirth C (2016). Mobilization of the Salmonella genomic island SGI1 and the Proteus genomic island PGI1 by the A/C2 plasmid carrying blaTEM-24 harboured by various clinical species of Enterobacteriaceae. J Antimicrob Chemother. 71(8):2167-70. [PudMed:27150396] |
| (7) Bellanger X; Payot S; Leblond-Bourget N; Guedon G (2014). Conjugative and mobilizable genomic islands in bacteria: evolution and diversity. FEMS Microbiol Rev. 38(4):720-60. [PudMed:24372381] |
| (8) Douard G; Praud K; Cloeckaert A; Doublet B (2010). The Salmonella genomic island 1 is specifically mobilized in trans by the IncA/C multidrug resistance plasmid family. PLoS One. 5(12):e15302. [PudMed:21187963] |
| (9) Boyd D; Peters GA; Cloeckaert A; Boumedine KS; Chaslus-Dancla E; Imberechts H; Mulvey MR (2001). Complete nucleotide sequence of a 43-kilobase genomic island associated with the multidrug resistance region of Salmonella enterica serovar Typhimurium DT104 and its identification in phage type DT120 and serovar Agona. J Bacteriol. 183(19):5725-32. [PudMed:11544236] |
| (10) Boyd DA; Peters GA; Ng L; Mulvey MR (2000). Partial characterization of a genomic island associated with the multidrug resistance region of Salmonella enterica Typhymurium DT104. FEMS Microbiol Lett. 189(2):285-91. [PudMed:10930753] |