ICEberg

ICE
Gene list
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References

I. Information of ICE

ICEberg ID	91
Name	Tn1545
ICEO ID	ICEO_0000689
Organism	Streptococcus pneumoniae BM4200
Size (bp)	-
GC content [Genome] (%)	-
Insertion site	-
Function	Resistance to sulfamethoxazole, trimethoprim, chloramphenicol, erythromycin, and streptomycin
Species that ICE can be transferred to	Enterococcus faecalis; Listeria monocytogenes;Enterococcus faecium
Nucleotide Sequence	AM889142; AM903082 (partial ICE sequence)
Putative oriT region	-
Putative relaxase	-

II. ICE interaction with IME/CIME/

The interaction information of Tn1545 is not available.

The graph information of Tn1545 components from AM903082

Incomplete gene list of Tn1545 from AM903082
#	Gene	Coordinates [+/-], size (bp)	Product (GenBank annotation)	*Reannotation
1	-	665..748 [+], 84	MLS leader peptide
2	ermB	873..1608 [+], 736	erythromycin ribosome methylase
3	sat4	2008..2538 [+], 531	streptothricin acetyltransferase
4	aphA-3	2631..3425 [+], 795	aminoglycoside phosphotransferase type III	AR
5	-	3756..4274 [+], 519	hypothetical protein
6	-	4893..4976 [+], 84	hypothetical protein
7	ermB	5101..5838 [+], 738	erythromycin ribosome methylase	AR
8	-	5783..5974 [+], 192	hypothetical protein
9	tnp	6095..7342 [-], 1248	putative transposase
10	-	7522..7743 [+], 222	hypothetical protein	Orf19_Tn, T4SS component

The graph information of Tn1545 components from AM889142

Incomplete gene list of Tn1545 from AM889142
#	Gene	Coordinates [+/-], size (bp)	Product (GenBank annotation)	*Reannotation
1	tnp	52..1005 [-], 954	putative IS1239 transposase	Integrase
2	-	1516..1602 [+], 87	tet(M) leader peptide
3	tet(M)	1618..3537 [+], 1920	tetracycline resistance protein TetM	AR

Gene may be involved in adaptative function

Element	No. of sequences	Download
Nucleotide sequences	0	Fasta
Proteins	0	Fasta

(1) Shen X; Yang H; Yu S; Yao K; Wang Y; Yuan L; Yang Y (2008). Macrolide-resistance mechanisms in Streptococcus pneumoniae isolates from Chinese children in association with genes of tetM and integrase of conjugative transposons 1545. Microb Drug Resist. 14(2):155-61. [PubMed:18479199]

(2) Seral C; Castillo FJ; Garcia C; Rubio-Calvo MC; Gomez-Lus R (2000). [Presence of conjugative transposon Tn1545 in strains of Streptococcus pneumoniae with mef(A), erm(B), tet(M), catpC194 and aph3'-III genes]. Enferm Infecc Microbiol Clin. 18(10):506-11. [PubMed:11198001]

(3) Woolley RC; Pennock A; Ashton RJ; Davies A; Young M (1989). Transfer of Tn1545 and Tn916 to Clostridium acetobutylicum. Plasmid. 22(2):169-74. [PubMed:2560219]

(4) Poyart-Salmeron C; Trieu-Cuot P; Carlier C; Courvalin P (1989). Molecular characterization of two proteins involved in the excision of the conjugative transposon Tn1545: homologies with other site-specific recombinases. EMBO J. 8(8):2425-33. [PubMed:2551683]

(5) Trieu-Cuot P; Poyart-Salmeron C; Carlier C; Courvalin P (1990). Nucleotide sequence of the erythromycin resistance gene of the conjugative transposon Tn1545. Nucleic Acids Res. 18(12):3660. [PubMed:2163525]

(6) Poyart-Salmeron C; Trieu-Cuot P; Carlier C; Courvalin P (1990). The integration-excision system of the conjugative transposon Tn 1545 is structurally and functionally related to those of lambdoid phages. Mol Microbiol. 4(9):1513-21. [PubMed:1962839]

(7) Doucet-Populaire F; Trieu-Cuot P; Dosbaa I; Andremont A; Courvalin P (1991). Inducible transfer of conjugative transposon Tn1545 from Enterococcus faecalis to Listeria monocytogenes in the digestive tracts of gnotobiotic mice. Antimicrob Agents Chemother. 35(1):185-7. [PubMed:1849709]

experimental literature