 ICEberg ID | 814 |
Name  | ICESp2906  |
| ICEO ID | ICEO_0000732 |
| Organism | Streptococcus pyogenes iB21 |
| Size (bp) | ~53.0 kb |
| GC content [Genome] (%) | - |
| Insertion site | 3' end of the conserved rum |
| Function | Antibiotic resistance genes: tet(O) |
| Species that ICE can be transferred to | Streptococcus pyogenes 24RF |
| Nucleotide Sequence | FR691055 (partial ICE sequence) |
| Putative oriT region | - |
| Putative relaxase | - |
The graph information of ICESp2906 components from FR691055 | |||||
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| Incomplete gene list of ICESp2906 from FR691055 | |||||
| # | Gene | Coordinates [+/-], size (bp) | Product (GenBank annotation) | *Reannotation | |
| 1 | rum | 285..1679 [+], 1395 | 23S rRNA m(5)U 1939 methyltransferase | ||
| 2 | - | 1838..2122 [+], 285 | hypothetical protein | ||
| 3 | - | 2137..2988 [+], 852 | Replication initiator protein A | ||
| 4 | - | 2985..3836 [+], 852 | DNA replication protein | ||
| 5 | - | 3833..4318 [+], 486 | hypothetical protein | ||
| 6 | - | 4315..6099 [+], 1785 | TraG/TraD/VirD4 family bacterial conjugation protein | ||
| 7 | - | 6153..6266 [+], 114 | hypothetical protein | ||
| 8 | - | 6266..6577 [+], 312 | hypothetical protein | ||
| 9 | - | 6581..6739 [+], 159 | hypothetical protein | ||
| 10 | - | 6857..7075 [+], 219 | Transcriptional regulator | ||
| 11 | - | 7079..7456 [+], 378 | hypothetical protein | ||
| 12 | - | 7866..8303 [+], 438 | MarR bacterial repressor protein | ||
| 13 | - | 8293..9600 [+], 1308 | MATE domain protein | ||
| 14 | - | 9700..9813 [+], 114 | hypothetical protein | ||
| 15 | erm(TR) | 10305..11036 [+], 732 | erythromycin resistance methylase | ||
 Flanking regions |
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(1) Morici E; Simoni S; Brenciani A; Giovanetti E; Varaldo PE; Mingoia M (2017). A new mosaic integrative and conjugative element from Streptococcus agalactiae carrying resistance genes for chloramphenicol (catQ) and macrolides [mef(I) and erm(TR)]. J Antimicrob Chemother. 72(1):64-67. [PubMed:27621174]
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(2) Giovanetti E; Brenciani A; Tiberi E; Bacciaglia A; Varaldo PE (2012). ICESp2905, the erm(TR)-tet(O) element of Streptococcus pyogenes, is formed by two independent integrative and conjugative elements. Antimicrob Agents Chemother. 56(1):591-4. [PubMed:21986826]
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| experimental literature |