I. Information of ICE

ICEberg ID	74
Name	ICEEcIHE3034-1
ICEO ID	ICEO_0000175
Organism	Escherichia coli IHE3034
Size (bp)	54445
GC content [Genome] (%)	53.06
Insertion site	tRNA-Asn
Function	Biosynthesis and secretion pathway of putative hybrid nonribosomal peptidepolyketide colibactin
Species that ICE can be transferred to	Enterobacteriaceae
Nucleotide Sequence	AM229678 (complete ICE sequence in this GenBank file)
Replicon	-
Coordinates	292..54752
Putative oriT region	-
Putative relaxase	-

II. ICE interaction with IME/CIME/

The interaction information of ICEEcIHE3034-1 is not available.

The graph information of ICEEcIHE3034-1 components from AM229678
Complete gene list of ICEEcIHE3034-1 from AM229678
#	Gene	Coordinates [+/-], size (bp)	Product  (GenBank annotation)	*Reannotation
1	intP4	469..1740 [+], 1272	bacteriophage integrase	Integrase
2	-	2020..2532 [-], 513	hypothetical protein
3	clbQ	2567..3289 [-], 723	putative thioesterase
4	clbP	3282..4796 [-], 1515	putative penicillin binding protein
5	clbO	4809..7268 [-], 2460	putative polyketide synthase
6	clbN	7299..11666 [-], 4368	putative non-ribosomal peptide synthetase
7	clbM	11663..13102 [-], 1440	putative drug/sodium antiporter
8	clbL	13164..14627 [-], 1464	putative amidase
9	clbK	14620..21084 [-], 6465	putative hybrid non-ribosomal peptide-polyketide synthetase
10	clbJ	21095..27595 [-], 6501	putative non-ribosomal peptide synthase
11	clbI	27639..30671 [-], 3033	putative polyketide synthase
12	clbH	30721..35517 [-], 4797	putative non-ribosomal peptide synthase
13	clbG	35565..36833 [-], 1269	putative malonyl-CoA transacylase
14	clbF	36830..37960 [-], 1131	putative acyl-CoA dehydrogenase
15	clbE	37964..38212 [-], 249	putative D-alanyl carrier protein
16	clbD	38242..39111 [-], 870	putative 3-hydroxyacyl-CoA dehydrogenase
17	clbC	39121..41721 [-], 2601	putative polyketide synthase
18	clbB	41762..51382 [-], 9621	putative hybrid polyketide-non-ribosomal peptide synthetase
19	clbR	51840..52052 [+], 213	putative regulatory protein
20	clbA	52053..52787 [+], 735	putative 4'-phosphopantetheinyl transferase
21	-	52933..53199 [+], 267	IS1400 transposase A
22	-	53304..53783 [+], 480	IS1400 transposase B
23	-	53774..54001 [+], 228	putative transposase

(1) Putze J; Hennequin C; Nougayrede JP; Zhang W; Homburg S; Karch H; Bringer MA; Fayolle C; Carniel E; Rabsch W; Oelschlaeger TA; Oswald E; Forestier C; Hacker J; Dobrindt U (2009). Genetic structure and distribution of the colibactin genomic island among members of the family Enterobacteriaceae. Infect Immun. 77(11):4696-703. [PubMed:19720753]

(2) Nougayrede JP; Homburg S; Taieb F; Boury M; Brzuszkiewicz E; Gottschalk G; Buchrieser C; Hacker J; Dobrindt U; Oswald E (2006). Escherichia coli induces DNA double-strand breaks in eukaryotic cells. Science. 313(5788):848-51. [PubMed:16902142]

experimental literature

in silico analysis literature