I. Information of ICE

ICEberg ID	445
Name	ICESsu32457
ICEO ID	ICEO_0000129
Organism	Streptococcus suis 32457
Size (bp)	54879
GC content [Genome] (%)	38.89
Insertion site	TTATTTAAGAGTAAC
Function	Carried Tetracycline resistance determinants tet(O/W/32/O), macrolide resistance determinant erm (B) and an aminoglycoside resistance four-gene cluster including aadE (streptomycin) and aphA (kanamycin)
Species that ICE can be transferred to	Streptococcus suis v36RF; Streptococcus pyogenes 12RF; Streptococcus pneumoniae R6RF; Streptococcus agalactiae 1357RF
Nucleotide Sequence	FR823304 (complete ICE sequence in this GenBank file)
Replicon	-
Coordinates	1..54879
Putative oriT region	-
Putative relaxase	coordinates: 2194..4059;   Family:  MOBP

II. ICE interaction with IME/CIME/

The interaction information of ICESsu32457 is not available.

The graph information of ICESsu32457 components from FR823304
Complete gene list of ICESsu32457 from FR823304
#	Gene	Coordinates [+/-], size (bp)	Product  (GenBank annotation)	*Reannotation
1	-	61..1260 [-], 1200	tyrosine family site-specific integrase	Integrase
2	-	1283..1510 [-], 228	hypothetical protein
3	-	1788..2012 [-], 225	transcriptional regulator, Cro/CI family
4	-	2194..4059 [-], 1866	Tn5252 relaxase	Relaxase, MOBP Family
5	-	4046..4411 [-], 366	Tn5252 ORF9 protein
6	-	4418..4780 [-], 363	Tn5252 ORF10 protein
7	-	5102..7609 [-], 2508	hypothetical protein
8	-	7707..8411 [-], 705	hypothetical protein
9	-	8411..8917 [-], 507	hypothetical protein
10	-	8957..9313 [-], 357	ATPases with chaperone activity, ATP-binding subunit
11	-	9303..9692 [-], 390	Methyl-accepting chemotaxis protein
12	-	9689..9916 [-], 228	hypothetical protein
13	-	9970..11046 [-], 1077	DNA primase
14	-	11086..11724 [-], 639	hypothetical protein
15	-	11820..12110 [-], 291	hypothetical protein
16	-	12682..12873 [-], 192	hypothetical protein
17	erm(B)	12818..13555 [-], 738	MLS methylase
18	-	13843..14022 [+], 180	hypothetical protein
19	-	14390..14695 [+], 306	hypothetical protein
20	-	14803..15303 [-], 501	hypothetical protein
21	-	15378..15653 [-], 276	hypothetical protein
22	-	15758..16123 [-], 366	hypothetical protein
23	aphA	16606..17400 [-], 795	aminoglycoside 3'-phosphotransferase
24	-	17748..18476 [-], 729	streptomycin 3'-adenylyltransferase
25	-	18689..19216 [-], 528	putative adenine phosphoribosyltransferase
26	-	19260..20105 [-], 846	streptomycin adenylyltransferase
27	-	20204..20602 [-], 399	hypothetical protein
28	-	20818..20985 [-], 168	transcriptional regulator Cro/CI family
29	tet(40)	21864..23084 [-], 1221	tetracycline resistance protein, efflux pump
30	tet(O/W/32/O)	23135..25054 [-], 1920	ribosomal protection tetracycline resistance protein
31	-	25181..25348 [+], 168	hypothetical protein
32	-	25421..25795 [-], 375	tnpV protein
33	-	25735..26466 [-], 732	hypothetical protein
34	-	26561..26851 [-], 291	hypothetical protein
35	-	26865..27164 [-], 300	hypothetical protein
36	-	27235..34059 [-], 6825	SNF2 family protein
37	-	34109..34660 [-], 552	hypothetical protein
38	-	34644..34835 [-], 192	hypothetical protein
39	-	34836..39722 [-], 4887	agglutinin receptor precursor	PrgB, T4SS component
40	-	40003..40593 [+], 591	abortive infection protein AbiGI
41	-	40590..41324 [+], 735	hypothetical protein
42	-	41496..44297 [-], 2802	CHAP domain containing protein	PrgK, T4SS component
43	-	44299..46629 [-], 2331	type IV secretory pathway, VirB4 component	PrgJ, T4SS component
44	-	46607..46960 [-], 354	hypothetical protein
45	-	47022..47876 [-], 855	Tn5252 ORF23
46	-	47895..48149 [-], 255	hypothetical protein
47	-	48155..49972 [-], 1818	type IV secretory pathway, VirD4 component	T4CP
48	-	49972..50460 [-], 489	hypothetical protein
49	-	50538..51122 [-], 585	CAAX amino terminal protease family protein
50	-	51125..51358 [-], 234	hypothetical protein
51	-	51367..51750 [-], 384	hypothetical protein
52	-	51761..52189 [-], 429	hypothetical protein
53	-	52173..53528 [-], 1356	C-5 cytosine-specific DNA methylase
54	-	53677..54495 [-], 819	replication initiator protein A (RepA) N-terminus
55	-	54492..54665 [-], 174	hypothetical protein

(1) Palmieri C; Magi G; Mingoia M; Bagnarelli P; Ripa S; Varaldo PE; Facinelli B (2012). Characterization of a Streptococcus suis tet(O/W/32/O)-carrying element transferable to major streptococcal pathogens. Antimicrob Agents Chemother. 56(9):4697-702. [PubMed:22710115]

(2) Palmieri C; Varaldo PE; Facinelli B (2011). Streptococcus suis, an Emerging Drug-Resistant Animal and Human Pathogen. Front Microbiol. 0.246527778. [PubMed:22275909]

experimental literature