I. Information of ICE

ICEberg ID	187
Name	6180-RD.2
Organism	Streptococcus pyogenes MGAS6180
Size (bp)	37429
GC content [Genome] (%)	35.13[38.35]
Insertion site	-
Function	Virulence: encodes cell surface anchored adhesins; R28.
Species that ICE can be transferred to	-
Nucleotide Sequence	CP000056 (complete ICE sequence in this genome)
Replicon	chromosome (1897573 bp, BioProject:13887) [NC_007296]
Genome coordinates	1284967..1322395
Putative oriT region	-
Putative relaxase	coordinates: 1300598..1301839; Locus tag: M28_Spy1321;  Family:  MOBT

II. ICE interaction with IME/CIME/

The interaction information of 6180-RD.2 is not available.

The graph information of 6180-RD.2 components from CP000056
Complete gene list of 6180-RD.2 from CP000056
#	Gene	Coordinates [+/-], size (bp)	Product  (GenBank annotation)	*Reannotation
1	valS	1280313..1282961 [-], 2649	valyl-tRNA synthetase
2	M28_Spy1297	1282963..1283547 [-], 585	hypothetical protein
3	M28_Spy1298	1283523..1283702 [-], 180	ribosomal-protein-serine acetyltransferase
4	M28_Spy1299	1284128..1284523 [-], 396	hypothetical cytosolic protein
5	M28_Spy1300	1284544..1284882 [-], 339	hypothetical protein
6	M28_Spy1301	1284867..1284983 [-], 117	hypothetical protein
7	M28_Spy1302	1284967..1286109 [-], 1143	transposase
8	M28_Spy1303	1286437..1287573 [-], 1137	DNA integration/recombination/invertion protein	Integrase
9	M28_Spy1304	1287623..1287955 [-], 333	hypothetical protein
10	M28_Spy1305	1288122..1288664 [-], 543	hypothetical protein
11	M28_Spy1306	1288887..1289648 [-], 762	putative cell surface protein	PrgC, T4SS component
12	M28_Spy1307	1289673..1290230 [-], 558	hypothetical exported protein
13	M28_Spy1308	1290230..1291588 [-], 1359	hypothetical exported protein
14	M28_Spy1309	1291723..1291866 [+], 144	hypothetical protein
15	M28_Spy1310	1292034..1294349 [-], 2316	membrane protein	YddG, T4SS component
16	M28_Spy1311	1294364..1296865 [-], 2502	DNA segregation ATPase related protein	YddE, T4SS component
17	M28_Spy1312	1296886..1297296 [-], 411	hypothetical protein	YddD, T4SS component
18	M28_Spy1313	1297299..1297568 [-], 270	hypothetical protein
19	M28_Spy1314	1297587..1298537 [-], 951	hypothetical protein	YddB, T4SS component
20	M28_Spy1315	1298538..1299017 [-], 480	hypothetical protein
21	M28_Spy1316	1299025..1299276 [-], 252	hypothetical protein
22	M28_Spy1317	1299306..1299515 [-], 210	hypothetical protein
23	M28_Spy1318	1299559..1299831 [-], 273	hypothetical protein
24	M28_Spy1319	1300026..1300169 [-], 144	transcriptional regulator, Cro/CI family
25	M28_Spy1320	1300220..1300597 [-], 378	hypothetical protein
26	M28_Spy1321	1300598..1301839 [-], 1242	transcriptional regulator, Cro/CI family	Relaxase, MOBT Family
27	M28_Spy1322	1302151..1303860 [-], 1710	FtsK/SpoIIIE family	YdcQ, T4SS component
28	M28_Spy1323	1303880..1304335 [-], 456	hypothetical protein
29	M28_Spy1324	1304338..1304643 [-], 306	hypothetical protein
30	M28_Spy1325	1304905..1308963 [-], 4059	putative cell surface protein	PrgB, T4SS component
31	M28_Spy1326	1309133..1311373 [-], 2241	putative cell surface protein	PrgA, T4SS component
32	M28_Spy1327	1311466..1311858 [-], 393	hypothetical protein
33	M28_Spy1328	1311982..1312422 [-], 441	hypothetical protein
34	M28_Spy1329	1312580..1313014 [-], 435	transcriptional regulator, Cro/CI family
35	M28_Spy1330	1313889..1314275 [+], 387	transcriptional regulator, Cro/CI family
36	M28_Spy1331	1314282..1314704 [+], 423	hypothetical protein
37	M28_Spy1332	1314769..1315125 [-], 357	hypothetical exported protein
38	M28_Spy1333	1315128..1315466 [-], 339	hypothetical protein
39	M28_Spy1334	1315463..1315756 [-], 294	hypothetical protein
40	M28_Spy1335	1315777..1315962 [+], 186	transposase
41	M28_Spy1336	1316468..1320961 [-], 4494	R28 protein
42	M28_Spy1337	1321190..1322395 [+], 1206	transcriptional regulator, AraC family
43	M28_Spy1338	1322913..1323665 [+], 753	phospho-2-dehydro-3-deoxyheptonate aldolase
44	aroB	1323706..1324794 [+], 1089	3-dehydroquinate synthase
45	M28_Spy1340	1325063..1325221 [-], 159	hypothetical protein
46	M28_Spy1341	1325229..1325534 [-], 306	hypothetical cytosolic protein
47	M28_Spy1342	1325536..1325874 [-], 339	hypothetical cytosolic protein
48	M28_Spy1343	1325927..1326682 [-], 756	SAM-dependent methyltransferase

Flanking regions

(1) Sitkiewicz I; Green NM; Guo N; Mereghetti L; Musser JM (2011). Lateral gene transfer of streptococcal ICE element RD2 (region of difference 2) encoding secreted proteins. BMC Microbiol. 0.503472222. [PubMed:21457552]

(2) Beres SB; Musser JM (2007). Contribution of exogenous genetic elements to the group A Streptococcus metagenome. PLoS One. 2(8):e800. [PubMed:17726530]

experimental literature