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I. Information of ICE

ICEberg ID	175
Name	PAPI-1
ICEO ID	ICEO_0000115
Organism	Pseudomonas aeruginosa UCBPP-PA14
Size (bp)	107953
GC content [Genome] (%)	59.74[66.29]
Insertion site	tRNA-Lys (Lys47)
Function	Virulence factors and regulation of biofilm formation
Species that ICE can be transferred to	-
Nucleotide Sequence	AY273869; CP000438 (complete ICE sequence in this genome)
Replicon	chromosome (6537648 bp, BioProject:386) [NC_008463]
Genome coordinates	5251440..5359392
Putative oriT region	-
Putative relaxase	coordinates: 5355824..5357743; Locus tag: PA14_60130;  Family:  MOBH

II. ICE interaction with IME/CIME/

The interaction information of PAPI-1 is not available.

The graph information of PAPI-1 components from CP000438
Complete gene list of PAPI-1 from CP000438
#	Gene	Coordinates [+/-], size (bp)	Product  (GenBank annotation)	*Reannotation
1	PA14_58900	5246954..5251207 [+], 4254	Large exoprotein
2	PA14_58910	5251580..5252446 [+], 867	chromosome partitioning related protein
3	PA14_58920	5252505..5253185 [+], 681	conserved hypothetical protein
4	PA14_58930	5253182..5253679 [+], 498	conserved hypothetical protein
5	PA14_58940	5253676..5253825 [+], 150	hypothetical protein
6	PA14_58950	5253822..5254508 [+], 687	conserved hypothetical protein
7	PA14_58960	5254508..5255209 [+], 702	hypothetical protein
8	PA14_58970	5255206..5255913 [+], 708	putative phage protein
9	PA14_58980	5255897..5256121 [+], 225	conserved hypothetical protein
10	PA14_58990	5256118..5257464 [+], 1347	Putative DNA helicase
11	PA14_59000	5257636..5258163 [+], 528	conserved hypothetical protein
12	PA14_59010	5258160..5258417 [+], 258	conserved hypothetical protein
13	PA14_59020	5258410..5258904 [+], 495	hypothetical protein
14	PA14_59030	5258897..5259130 [+], 234	hypothetical protein
15	PA14_59050	5259130..5260146 [+], 1017	conserved hypothetical protein
16	PA14_59060	5260143..5260397 [+], 255	hypothetical protein
17	PA14_59070	5260394..5262133 [+], 1740	conserved hypothetical protein
18	PA14_59090	5262161..5262928 [+], 768	conserved hypothetical protein
19	PA14_59100	5262925..5264250 [+], 1326	conserved hypothetical protein
20	PA14_59110	5264247..5264522 [+], 276	hypothetical protein
21	PA14_59120	5264513..5264752 [+], 240	hypothetical protein
22	PA14_59130	5265022..5265750 [+], 729	conserved hypothetical protein
23	PA14_59140	5265756..5266289 [+], 534	conserved hypothetical protein
24	PA14_59150	5266303..5266773 [+], 471	putative single-stranded DNA binding protein
25	PA14_59160	5267237..5267482 [+], 246	hypothetical protein
26	PA14_59170	5267621..5267854 [-], 234	hypothetical protein
27	PA14_59180	5268174..5270099 [+], 1926	topoisomerase I - like protein
28	PA14_59190	5270173..5270643 [+], 471	hypothetical protein
29	PA14_59200	5270777..5272666 [+], 1890	conserved hypothetical protein
30	PA14_59210	5272663..5274636 [+], 1974	putative DNA helicase
31	PA14_59220	5275324..5276820 [+], 1497	pyocin S5
32	PA14_59230	5276845..5277171 [-], 327	colicin immunity protein
33	pilL2	5277443..5278567 [+], 1125	type IV B pilus protein	Tfc2, T4SS component
34	pilN2	5278639..5280276 [+], 1638	Type IV B pilus protein
35	pilO2	5280280..5281605 [+], 1326	type IV b pilus protein
36	pilP2	5281595..5282128 [+], 534	type IV B pilus protein
37	pilQ2	5282137..5283717 [+], 1581	type IV B pilus protein	DotB, T4SS component
38	pilR2	5283717..5284796 [+], 1080	type IV B pilus Protein
39	pilS2	5284818..5285348 [+], 531	type IV B pilus protein
40	pilT2	5285345..5286286 [+], 942	type IV B pilus protein	TraJ_I, T4SS component
41	pilV2	5286291..5287619 [+], 1329	Type IV B pilus protein
42	pilM2	5287648..5288085 [+], 438	type IV B pilus protein
43	PA14_59370	5288357..5289001 [-], 645	hypothetical protein
44	PA14_59380	5289000..5289566 [+], 567	conserved hypothetical protein
45	PA14_59390	5289818..5289952 [+], 135	hypothetical protein
46	PA14_59400	5290227..5290766 [+], 540	conserved hypothetical protein
47	PA14_59410	5290815..5291081 [-], 267	hypothetical protein
48	PA14_59430	5291101..5291337 [+], 237	conserved hypothetical protein
49	PA14_59440	5291822..5292529 [+], 708	conserved hypothetical protein
50	PA14_59470	5292765..5293115 [+], 351	hypothetical protein
51	PA14_59480	5293173..5293808 [+], 636	conserved hypothetical protein
52	PA14_59490	5293805..5294080 [+], 276	hypothetical protein
53	PA14_59500	5294150..5294512 [+], 363	conserved hypothetical protein
54	PA14_59510	5294580..5294834 [+], 255	conserved hypothetical protein
55	PA14_59520	5294926..5295531 [+], 606	hypothetical protein
56	PA14_59530	5295561..5297012 [+], 1452	conserved hypothetical protein
57	PA14_59540	5297117..5299366 [+], 2250	conserved hypothetical protein
58	PA14_59550	5299690..5300916 [+], 1227	hypothetical protein
59	PA14_59560	5301173..5301439 [+], 267	putative transposase
60	PA14_59570	5301490..5301825 [+], 336	putative transposase
61	PA14_59580	5301889..5303424 [+], 1536	putative transposase
62	PA14_59590	5303485..5303844 [+], 360	conserved hypothetical protein
63	PA14_59600	5303917..5304162 [-], 246	hypothetical protein
64	PA14_59610	5304246..5304920 [-], 675	conserved hypothetical protein
65	PA14_59620	5305003..5305668 [-], 666	conserved hypothetical protein
66	PA14_59630	5305679..5306710 [-], 1032	hypothetical protein
67	PA14_59640	5307321..5308010 [+], 690	conserved hypothetical protein	Tfc2, T4SS component
68	PA14_59650	5308021..5308776 [+], 756	conserved hypothetical protein	Tfc3, T4SS component
69	PA14_59660	5308761..5309342 [+], 582	conserved hypothetical protein	Tfc4, T4SS component
70	PA14_59670	5309339..5309839 [+], 501	conserved hypothetical protein	Tfc5, T4SS component
71	PA14_59680	5309848..5310105 [+], 258	hypothetical protein
72	PA14_59690	5310109..5312343 [+], 2235	conserved hypothetical protein	Tfc6, T4SS component
73	PA14_59700	5312343..5313089 [+], 747	conserved hypothetical protein	Tfc8, T4SS component
74	cupD1	5313527..5314075 [+], 549	putative fimbrial protein precursor
75	cupD2	5314164..5314910 [+], 747	putative pili assembly chaperone
76	cupD4	5317504..5318850 [+], 1347	fimbrial subunit
77	cupD5	5318840..5319556 [+], 717	putative pili assembly chaperone
78	rcsB	5319600..5320295 [-], 696	putative two component response regulator
79	rcsC	5320295..5323549 [-], 3255	putative kinase sensor protein
80	pvrR	5323630..5324829 [-], 1200	two component response regulator
81	PA14_59800	5324826..5327621 [-], 2796	kinase sensor protein
82	PA14_59820	5327953..5328603 [+], 651	conserved hypothetical protein	Tfc8, T4SS component
83	PA14_59830	5328614..5330095 [+], 1482	putative helicase	TraI_F, T4SS component
84	PA14_59840	5330226..5331335 [+], 1110	conserved hypothetical protein
85	PA14_59845	5331379..5331690 [-], 312	conserved hypothetical protein
86	PA14_59850	5331863..5332168 [+], 306	hypothetical protein
87	PA14_59860	5332241..5332600 [+], 360	putative candidate type III effector Hop protein	Tfc9, T4SS component
88	PA14_59870	5332597..5332836 [+], 240	conserved hypothetical protein
89	PA14_59880	5332854..5333210 [+], 357	conserved hypothetical protein	Tfc10, T4SS component
90	PA14_59890	5333221..5333607 [+], 387	conserved hypothetical protein	Tfc11, T4SS component
91	PA14_59900	5333604..5334263 [+], 660	conserved hypothetical protein	Tfc12, T4SS component
92	PA14_59910	5334260..5335144 [+], 885	conserved hypothetical protein	Tfc13, T4SS component
93	PA14_59920	5335128..5336633 [+], 1506	conserved hypothetical protein	Tfc14, T4SS component
94	PA14_59930	5336611..5337054 [+], 444	conserved hypothetical protein	Tfc15, T4SS component
95	PA14_59940	5337054..5339996 [+], 2943	conserved hypothetical protein	Tfc16, T4SS component
96	PA14_59950	5339993..5340277 [+], 285	hypothetical protein
97	PA14_59960	5340274..5340933 [+], 660	Putative protein-disulfide isomerase
98	PA14_59970	5340930..5341148 [-], 219	conserved hypothetical protein
99	PA14_59980	5341357..5341788 [+], 432	hypothetical protein	Tfc24, T4SS component
100	PA14_59990	5341788..5342726 [+], 939	conserved hypothetical protein	Tfc23, T4SS component
101	PA14_60000	5342744..5344126 [+], 1383	conserved hypothetical protein	Tfc22, T4SS component
102	PA14_60010	5344126..5344467 [+], 342	hypothetical protein
103	PA14_60020	5344464..5345975 [+], 1512	conserved hypothetical protein	Tfc19, T4SS component
104	PA14_60030	5346001..5346345 [-], 345	hypothetical protein
105	PA14_60040	5346464..5346736 [+], 273	conserved hypothetical protein
106	PA14_60050	5346740..5347090 [+], 351	putative plasmid stablization protein
107	PA14_60060	5347532..5347834 [+], 303	hypothetical protein
108	PA14_60070	5348012..5350435 [+], 2424	conserved hypothetical protein
109	PA14_60080	5350432..5352363 [+], 1932	conserved hypothetical protein
110	PA14_60090	5352790..5353305 [+], 516	hypothetical protein
111	dtd	5353510..5354049 [-], 540	deoxycytidine triphosphate deaminase
112	PA14_60110	5354046..5354756 [-], 711	hypothetical protein
113	dcd2	5354756..5355289 [-], 534	putative deoxycytidine deaminase
114	PA14_60130	5355824..5357743 [+], 1920	conserved hypothetical protein	Relaxase, MOBH Family
115	PA14_60140	5357740..5358660 [+], 921	xerD-like putative integrase	Integrase
116	clpB	5359875..5362439 [-], 2565	clpB protein
117	PA14_60200	5362595..5363323 [-], 729	conserved hypothetical protein
118	rluD	5363320..5364282 [-], 963	ribosomal large subunit pseudouridine synthase D

Flanking regions

Element	No. of sequences	Download
Nucleotide sequences	1	Fasta
Proteins	114	Fasta

(1) Seth-Smith HM; Fookes MC; Okoro CK; Baker S; Harris SR; Scott P; Pickard D; Quail MA; Churcher C; Sanders M; Harmse J; Dougan G; Parkhill J; Thomson NR (2012). Structure, diversity, and mobility of the Salmonella pathogenicity island 7 family of integrative and conjugative elements within Enterobacteriaceae. J Bacteriol. 194(6):1494-504. [PubMed:22247511]

(2) Carter MQ; Chen J; Lory S (2010). The Pseudomonas aeruginosa pathogenicity island PAPI-1 is transferred via a novel type IV pilus. J Bacteriol. 192(13):3249-58. [PubMed:20363934]

(3) Harrison EM; Carter ME; Luck S; Ou HY; He X; Deng Z; O'Callaghan C; Kadioglu A; Rajakumar K (2010). Pathogenicity islands PAPI-1 and PAPI-2 contribute individually and synergistically to the virulence of Pseudomonas aeruginosa strain PA14. Infect Immun. 78(4):1437-46. [PubMed:20123716]

(4) Mathee K; Narasimhan G; Valdes C; Qiu X; Matewish JM; Koehrsen M; Rokas A; Yandava CN; Engels R; Zeng E; Olavarietta R; Doud M; Smith RS; Montgomery P; White JR; Godfrey PA; Kodira C; Birren B; Galagan JE; Lory S (2008). Dynamics of Pseudomonas aeruginosa genome evolution. Proc Natl Acad Sci U S A. 105(8):3100-5. [PubMed:18287045]

(5) He J; Baldini RL; Deziel E; Saucier M; Zhang Q; Liberati NT; Lee D; Urbach J; Goodman HM; Rahme LG (2004). The broad host range pathogen Pseudomonas aeruginosa strain PA14 carries two pathogenicity islands harboring plant and animal virulence genes. Proc Natl Acad Sci U S A. 101(8):2530-5. [PubMed:14983043]

experimental literature

in silico analysis literature

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