| Effector Protein ID: 296106553 |
 T4SS name [ID] | Dot/Icm [43] |
| Gene symbol | - |
| Locus tag | lpa_01460 |
| Strain | Legionella pneumophila 2300/99 Alcoy |
| Replicon | chromosome [GenBank: NC_014125] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 1156676..1158370 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | SidK |
| T4CP requirement | T4CP Depedent |
| Target/Effection | SidK interacts with VatA, a key component of the proton pump, leading to the inhibition of ATP hydrolysis and proton translocation. When delivered into macrophages, SidK inhibits vacuole acidification and bacterial killing. (Xu et al., 2010) |
| UniProt ID | D5TBQ2 |
| KEGG ID | lpa:lpa_01460 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | NA |
| Protein Sequence: 564 a.a. [Download] |
| >gi|296106553|ref|YP_003618253.1| hypothetical protein lpa_01460 [Legionella pneumophila 2300/99 Alcoy] MGGLTSEQYHSQVVGKIGYIARCMQTIDPENNLKKIREDYQDVLIWAEKNYRFEEILEASKSGKCPNDLD ALSRRSLILQELLRLVSSISPFKMKLDLIESQYEKMKQHVNLWKSDYHVKLNQLNQLTDYLKNAAPTPKN HFLRAMTSALQMQIAQYGITEDNEGINQLFKLGLHLLAMANEKIDEQYHLFKRYVKDQPEESPFEGILPV EDQKILVKAMIDYAVPKLSLKVLQDKLSALSSSDALTKTLLDSIDRIVEENEKLNALSKVKLGKFSLDIR EIEEIYSQALKISPQDALLYTAQQCDAKLLSMAFPDSQNYIVESISNKEAKAIAELIHSKEFLYQIIKTE VLKQVDPNEKIRLQAAIELYQLLGRTMDKQIHLFAKMNLEQINEYIQTKTKSILDKIPERVELLTFMGFE IPTFKGIETLMTDISHSQDNETLAIAQEFYTNIKNAKNQLLGDKLIEDITPQDVEKFFNQCSQYGSEAAE KLADNRPVLTKIADILTAIARWAISLIGFNTPPQFLAPTRTCVDQVSDEITKIKLKLEDTLGSLRKAQEE SLSL |
| - |
| Nucleotide Sequence: 1695 bp [Download] |
| >gi|296105497|ref|NC_014125.1|:c1158370-1156676 Legionella pneumophila 2300/99 Alcoy chromosome, complete genome ATGGGTGGCTTAACTAGCGAGCAATATCATAGTCAAGTAGTCGGCAAAATTGGATATATCGCCAGATGCA TGCAAACTATAGATCCTGAAAATAATTTGAAAAAGATAAGAGAAGATTACCAAGATGTATTGATATGGGC AGAGAAAAATTATCGTTTTGAAGAAATATTGGAAGCCAGCAAATCTGGAAAGTGCCCAAATGATCTGGAT GCATTAAGTCGACGATCGTTAATACTCCAAGAATTGCTACGGCTTGTTTCATCAATTAGTCCCTTTAAAA TGAAATTAGACCTGATTGAGTCTCAATATGAGAAAATGAAACAACATGTGAATTTATGGAAAAGTGATTA CCATGTAAAACTAAATCAATTGAATCAATTAACAGACTACCTCAAAAATGCAGCACCAACTCCTAAAAAT CATTTTCTAAGAGCAATGACCTCTGCATTGCAAATGCAGATAGCCCAATATGGGATTACAGAAGATAATG AGGGTATCAACCAGTTGTTTAAACTGGGATTGCATTTACTCGCAATGGCTAACGAAAAAATAGATGAACA ATATCATCTGTTTAAAAGGTATGTAAAAGATCAGCCAGAAGAATCTCCTTTTGAGGGCATTTTGCCTGTG GAAGACCAGAAAATTTTAGTCAAAGCTATGATAGATTATGCCGTGCCGAAACTTTCACTTAAGGTTTTAC AAGATAAATTATCAGCACTATCCAGTTCCGATGCATTAACAAAAACATTACTTGATAGCATCGACAGAAT TGTTGAAGAAAACGAAAAATTAAATGCTTTAAGCAAAGTCAAATTAGGTAAATTTAGCCTGGATATCAGG GAAATTGAAGAGATATACTCTCAAGCTCTGAAAATATCACCACAAGATGCTTTGCTATATACTGCTCAAC AATGTGATGCCAAATTATTAAGCATGGCATTTCCTGATTCCCAAAATTACATTGTTGAATCTATATCGAA CAAAGAGGCCAAGGCCATTGCAGAGCTAATCCATAGTAAAGAATTTCTTTATCAAATTATTAAAACAGAA GTTTTAAAACAAGTTGATCCTAATGAGAAAATTCGACTACAAGCCGCAATAGAATTGTATCAGCTTCTTG GGAGAACCATGGATAAACAGATCCATCTTTTTGCCAAGATGAATCTCGAACAAATTAATGAATATATTCA AACCAAAACCAAATCAATCCTGGATAAAATTCCTGAAAGAGTTGAGTTATTAACTTTTATGGGCTTTGAA ATTCCAACTTTCAAGGGAATTGAGACGCTTATGACCGACATCTCCCATTCTCAGGATAATGAAACTCTGG CGATAGCCCAAGAATTTTATACAAATATAAAAAATGCCAAGAACCAATTGTTGGGTGATAAACTGATTGA AGACATTACTCCACAGGATGTAGAGAAATTTTTTAATCAATGTAGTCAATACGGTTCAGAAGCAGCTGAA AAGTTAGCTGACAATCGCCCGGTACTGACAAAAATTGCTGATATTTTGACTGCCATTGCCCGTTGGGCGA TTAGTTTAATAGGTTTCAACACGCCACCGCAGTTTTTGGCTCCAACCAGAACATGTGTGGATCAGGTATC TGATGAAATCACTAAAATTAAACTCAAACTTGAAGATACTTTGGGAAGCTTGCGAAAAGCACAGGAAGAA AGCCTAAGTCTTTAA |
| Reference |
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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| in silico analysis literature |