SecReT4
T4SS ID486
StrainRickettsia rickettsii str. Iowa
Repliconchromosome [Browse all T4SS(s) in this replicon]
AccessionNC_010263
Location134119..151449; 255312..255671; 388855..396733; 1119068..1121500
NameVirB
Functioneffector translocation
ClassificationType IVA; Type P
insolico Bioinformatics investigation has been performed on this T4SS.

T4SS components
ComponentVirB1VirB2VirB3VirB4VirB5VirB6VirB7VirB8VirB9
Number011205022
ComponentVirB10VirB11VirD4
Number111

The information of T4SS components from NC_010263
Region 1: 134119..151449
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1RrIowa_0167129409..129504 [-], 96165932703hypothetical protein 
2RrIowa_0168129847..130257 [-], 411165932704hypothetical protein 
3RrIowa_0169130705..130935 [-], 231165932705hypothetical protein 
4RrIowa_0170130962..131108 [-], 147165932706hypothetical protein 
5RrIowa_0171131105..131242 [-], 138165932707hypothetical protein 
6RrIowa_0172131717..132010 [+], 29416593270850S ribosomal protein L28 
7RrIowa_0173132007..132243 [+], 23716593270950S ribosomal protein L31 
8RrIowa_0175 (yihA)132558..133235 [+], 678165932710GTP-binding protein YsxC 
9RrIowa_0176133306..134106 [+], 801165932711acetylglutamate kinase 
10RrIowa_0177 (virB3)134119..134406 [+], 288165932712type IV secretion system protein VirB3  VirB3
11RrIowa_0178 (virB4.1)134622..137039 [+], 2418165932713type IV secretion system ATPase VirB4  VirB4
12RrIowa_0179 (virB6.1)137157..140117 [+], 2961165932714channel protein  VirB6
13RrIowa_0180 (virB6.2)140104..142089 [+], 1986165932715channel protein  VirB6
14RrIowa_0181 (virB6.3)142096..144996 [+], 2901165932716channel protein  VirB6
15RrIowa_0182 (virB6.4)145160..147835 [+], 2676165932717channel protein  VirB6
16RrIowa_0183 (virB6.5)147988..151449 [+], 3462165932718channel protein  VirB6
17RrIowa_0189154288..154416 [+], 129165932719hypothetical protein 
18RrIowa_0190154413..154511 [+], 99165932720hypothetical protein 
19RrIowa_0191154764..155468 [+], 705165932721tRNA (guanine-N(1)-)-methyltransferase 
20RrIowa_0192155486..155902 [+], 41716593272250S ribosomal protein L19 
21RrIowa_0193156072..156308 [-], 237165932723hypothetical protein 
 
Region 2: 255312..255671
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1RrIowa_0290250698..250901 [+], 204165932816hypothetical protein 
2RrIowa_0291251117..251458 [-], 342165932817hypothetical protein 
3RrIowa_0292251626..252099 [+], 474165932818hypothetical protein 
4RrIowa_0293252107..253081 [+], 975165932819DNA polymerase III subunit delta 
5RrIowa_0294253217..253756 [+], 5401659328202-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 
6RrIowa_0295254230..255156 [+], 927165932821cytochrome c oxidase polypeptide III 
7RrIowa_0296255312..255671 [+], 360165932822hypothetical protein  VirB2
8RrIowa_0297256015..256647 [-], 633165932823hypothetical protein 
9RrIowa_0298256700..257548 [+], 8491659328242,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 
10RrIowa_0299257988..258227 [-], 240165932825hypothetical protein 
11RrIowa_0300258652..258849 [-], 198165932826hypothetical protein 
12RrIowa_0301258978..259247 [-], 270165932827hypothetical protein 
13RrIowa_0302259235..259423 [-], 189165932828hypothetical protein 
14RrIowa_0303259464..259616 [-], 153165932829hypothetical protein 
 
Region 3: 388855..396733
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1RrIowa_0458384664..385068 [-], 405165932957virulence-associated protein C 
2RrIowa_0459385059..385358 [-], 300165932958hypothetical protein 
3RrIowa_0460 (shaA)385533..386996 [-], 1464165932959putative monovalent cation/H+ antiporter subunit D 
4RrIowa_0461 (shaD)387143..388444 [-], 1302165932960putative monovalent cation/H+ antiporter subunit D 
5RrIowa_0462 (shaC)388441..388776 [-], 336165932961putative monovalent cation/H+ antiporter subunit C 
6RrIowa_0463 (virB9.1)388855..389607 [-], 753165932962channel protein  VirB9
7RrIowa_0464 (virB8.1)389609..390307 [-], 699165932963channel protein  VirB8
8RrIowa_0465 (virB7)390772..390951 [+], 180165932964channel protein 
9RrIowa_0466 (virB8.2)391001..391732 [+], 732165932965channel protein  VirB8
10RrIowa_0467 (virB9.2)391719..392192 [+], 474165932966channel protein  VirB9
11RrIowa_0468 (virB10)392375..393823 [+], 1449165932967channel protein  VirB10
12RrIowa_0469 (virB11)393820..394824 [+], 1005165932968type IV secretion system ATPase VirB11  VirB11
13RrIowa_0470 (virD4)394958..396733 [+], 1776165932969type IV secretion system component VirD4  VirD4
14RrIowa_0471396726..398147 [+], 1422165932970exopolyphosphatase 
15RrIowa_0472398144..398341 [-], 198165932971hypothetical protein 
16RrIowa_0473398361..398672 [-], 312165932972hypothetical protein 
17RrIowa_0474398987..399133 [-], 147165932973hypothetical protein 
18RrIowa_0475399608..399847 [-], 240165932974hypothetical protein 
19RrIowa_0476400158..400442 [+], 285165932975hypothetical protein 
20RrIowa_0477400550..400843 [-], 294165932976phage host specificity protein 
 
Region 4: 1119068..1121500
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProductComponent
1RrIowa_1423 (ampG.4)1114994..1116646 [+], 1653165933771AmpG 
2RrIowa_1424 (tatC)1116713..1117468 [+], 756165933772Sec-independent protein translocase protein 
3RrIowa_14251117446..1118723 [+], 1278165933773seryl-tRNA synthetase 
4RrIowa_14261118768..1118983 [+], 216165933774hypothetical protein 
5RrIowa_1427 (virB4.2)1119068..1121500 [+], 2433165933775VirB4 ATPase  VirB4
6RrIowa_14281121636..1125124 [+], 3489165933776hypothetical protein 
7RrIowa_1429 (terC)1125129..1126034 [+], 906165933777tellurium resistance protein 
 
flank Genes in the 5-Kb flanking regions if available, or non-essential genes in the T4SS gene cluster if any.

Download FASTA format files
Proteins        Genes

Effectors
Rickettsia ankyrin repeat protein 2 (RARP-2)

The information of protein effectors
#Locus tag (Gene)Coordinates [+/-], size (bp)Protein GIProduct  *
1RrIowa_1113 881136..882398 [-], 1263165933520hypothetical proteinexperimental  Rickettsia ankyrin repeat protein 2 (RARP-2)interaction
experimental T4SE derived from experimental literature.
interaction This effector contains information of interaction.

Download FASTA format files
Proteins        Genes
The information on host-pathogen interaction.

#Name(Protein GI)Host site/SubstrateSourceFunctionReference
1RARP-2 (165933520)Endoplasmic reticulum (ER)apeRARP-2 interacts with ER.(1) PubMed: 29946049experimental
experimental This T4SE is mentioned in the literature.

(1) Lehman SS et al. (2018). The Rickettsial Ankyrin Repeat Protein 2 Is a Type IV Secreted Effector That Associates with the Endoplasmic Reticulum. MBio. 9(3):e00975-18. [PudMed:29946049] experimental
(1) Gillespie JJ; Ammerman NC; Dreher-Lesnick SM; Rahman MS; Worley MJ; Setubal JC; Sobral BS; Azad AF (2009). An anomalous type IV secretion system in Rickettsia is evolutionarily conserved. PLoS One. 4(3):e4833. [PudMed:19279686] in_silico
 
in_silico This literature contains bioinformatics investigation

Genomics & Bioinformatics Group in MML, SJTU