| Effector Protein ID: 52841946 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | legAS4 |
| Locus tag | lpg1718 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 1914091..1915728 [-] |
| Product | hypothetical protein |
| Effector type | Protein |
| Descripton | AnkI/legAS4 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | Unknown |
| UniProt ID | Q5ZUS4 |
| KEGG ID | lpn:lpg1718 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | SET [PF00856], Evalue: 7.9e-19, Aligned region: 130..234 Ank_2 [PF12796], Evalue: 8.9e-15, Aligned region: 332..363 Ank_2 [PF12796], Evalue: 8.9e-15, Aligned region: 338..433 Ank_3 [PF13606], Evalue: 1.1e-10, Aligned region: 335..361 Ank [PF00023], Evalue: 1.3e-10, Aligned region: 335..363 Ank_4 [PF13637], Evalue: 5e-09, Aligned region: 336..365 Ank_5 [PF13857], Evalue: 3.7e-08, Aligned region: 334..364 |
| Protein Sequence: 545 a.a. [Download] |
| >gi|52841946|ref|YP_095745.1| hypothetical protein lpg1718 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MIILYDFLQESSVMPRSKNDSKLKKKSALQSKFKEQQLNHGSKEHKSKFKFSQRKAKKKGPGMTHLPGNI YTLFTPVNGPKSKDEWIDTSKIMLDLHIDNMSSSDYIPSAIDRTDLVMVQSVHLLRKTGGRGLFAREDIP KGTCIGIYTGEVYSEQEFEQYLKEHVGSDKSYAMYVGGRVIDAARKGNLTRYINFSDSQDNAEFVETTLN RKKVAKVITTKNIKAGQQLLINYNTYEEQASRYYYFLNPGDGWLSAQEFYQTYQSQYRLEQMPYNLEGFD LKAGDRVLMTQIGRIILANYSLAKEQELNASDIDLPFLKVGSDEKILDFDEADTFTPLMAACYLGQVENV KWLIEHGANIDQQQSHSGHCPLSLTLKGYSLAKDTQKYIDIIQLLIKNQVNLLVHDRSDKTFLHNAALVL NNLDFQSVVKFLIGQNPIDINEYFTYIDENDFDIVMHCYNNKLFDKALVLLAFYPDYFKRNYMSDNEGHN QFNINAFRKAIKDFNSNERSILLMQLRESGLHLPEDLLEQLGIMDSSITLESKFF |
| - |
| Nucleotide Sequence: 1638 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:c1915728-1914091 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGATTATTTTATATGATTTTTTACAAGAGAGCAGTGTTATGCCAAGAAGCAAGAATGATAGCAAACTTA AAAAGAAAAGTGCCCTTCAGTCAAAGTTTAAAGAACAGCAATTGAATCATGGTAGTAAAGAGCACAAATC TAAATTTAAATTTTCCCAAAGAAAGGCAAAGAAAAAAGGACCTGGGATGACACACCTCCCAGGTAATATT TACACGCTGTTTACTCCTGTCAATGGACCGAAAAGCAAGGATGAATGGATTGACACGAGCAAAATTATGC TTGATTTACATATTGATAACATGTCAAGCAGCGATTACATTCCATCTGCTATAGACAGAACTGATCTTGT TATGGTTCAGTCTGTCCATTTACTCAGAAAAACCGGCGGACGAGGTTTATTTGCCAGGGAAGATATCCCA AAGGGGACTTGTATTGGTATTTACACAGGAGAAGTATATTCTGAACAAGAATTTGAACAATATCTAAAGG AACATGTTGGTTCTGATAAAAGTTACGCGATGTATGTTGGGGGACGGGTAATTGATGCAGCAAGAAAAGG TAATTTGACTCGTTATATCAATTTTTCGGATAGTCAGGATAATGCAGAGTTTGTTGAAACTACATTGAAT CGCAAGAAAGTAGCAAAAGTTATAACCACTAAAAACATCAAGGCAGGACAACAACTATTAATCAACTATA ATACCTACGAAGAGCAGGCCTCCAGGTATTATTACTTTCTTAATCCTGGCGATGGTTGGCTATCGGCACA AGAATTTTATCAAACTTATCAATCTCAGTACCGATTAGAACAAATGCCCTATAATTTGGAAGGATTTGAT CTTAAAGCAGGGGATAGAGTTTTAATGACTCAAATAGGACGGATAATTTTAGCTAACTATTCTCTTGCAA AAGAACAAGAATTAAATGCCTCAGATATCGATTTGCCATTTTTAAAAGTGGGTTCTGACGAAAAAATATT AGATTTTGATGAAGCGGATACATTCACCCCTTTGATGGCTGCCTGTTATCTTGGACAAGTTGAAAATGTA AAATGGCTTATTGAACATGGTGCTAATATCGATCAACAGCAAAGTCATTCTGGTCATTGTCCTTTGAGTT TGACATTGAAAGGATATTCTTTAGCGAAGGATACCCAAAAATACATTGATATCATTCAGCTATTGATTAA AAATCAGGTTAATCTTTTAGTGCATGACCGATCAGACAAGACTTTTTTACATAATGCCGCATTAGTACTG AATAACCTTGATTTTCAATCTGTTGTAAAATTTTTAATAGGACAAAATCCTATTGATATCAATGAATACT TTACATACATCGATGAGAATGATTTCGATATCGTCATGCATTGTTATAACAATAAATTATTTGATAAAGC TCTTGTTTTATTGGCTTTTTATCCGGATTATTTTAAAAGAAATTATATGAGTGATAATGAAGGGCATAAT CAATTTAATATCAATGCTTTTAGAAAAGCGATAAAAGATTTTAACTCAAATGAGCGTAGTATTTTATTAA TGCAGCTCAGGGAGAGCGGTTTGCATTTGCCTGAAGACTTGTTAGAGCAATTAGGTATTATGGATTCAAG TATCACACTTGAAAGCAAGTTTTTTTGA |
| Reference |
(1) Li T et al. (2013). SET-domain bacterial effectors target heterochromatin protein 1 to activate host rDNA transcription. EMBO Rep. 14(8):733-40. [PudMed:23797873] 
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(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(3) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377]
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| experimental literature |
| in silico analysis literature |