| ICE family: Tn5253 | ||||
| Tn5253 is a composite structure of two conjugative transposons, Tn5251 and Tn5252. We selected it as a reference and defined Tn5253 family. We classified ICE that has significant sequence alignment and syntenic 'core' structure with Tn5253 into the Tn5253 family, including Tn5252 and Tn5252-like ICEs. | ||||
| # | ID | ICE name | Strain | Replicon |
| 1 | 84  | ICESpn11930 | Streptococcus pneumoniae 11930 | - |
| 2 | 88 | ICESpn11876 | Streptococcus pneumoniae 11876 | - |
| 3 | 95  | Tn5252 (part of Tn5253) | Streptococcus pneumoniae BM6001 | - |
| 4 | 165 | ICE6094 | Streptococcus pneumoniae Pn19 | - |
| 5 | 230 | ICESp23FST81 | Streptococcus pneumoniae ATCC 700669 | NC_011900 |
| 6 | 317 | Tn2008 | Streptococcus pneumoniae CGSP14 | NC_010582 |
| 7 | 362 | Tn1311 | Streptococcus pneumoniae SpnF21 | - |
| 8 | 363 | ICESpnA213 | Streptococcus pneumoniae SpnA213 | - |
| 9 | 364 | Tn5253 | Streptococcus pneumoniae DP1322 | - |
| 10 | 365 | ICESpnKD6 | Streptococcus pneumoniae KD6 | - |
| 11 | 366 | ICESpnN24 | Streptococcus pneumoniae N24 | - |
| 12 | 367 | ICESpnJ93183 | Streptococcus pneumoniae J93/183 | - |
| 13 | 368 | ICESpnJ93292 | Streptococcus pneumoniae J93/292 | - |
| 14 | 369 | ICESpn2531 | Streptococcus pneumoniae PN02/2531 | - |
| 15 | 370 | Tn5252(SP1000) | Streptococcus pneumoniae SP1000 | - |
| 16 | 371 | Tn5252-like | Streptococcus pneumoniae | - |
| 17 | 372 | ICESpnP1031-1 | Streptococcus pneumoniae P1031 | NC_012467 |
| 18 | 373 | ICESpn6706B-1 | Streptococcus pneumoniae 670-6B | NC_014498 |
| 19 | 815 | ICESpn22664 | Streptococcus pneumoniae 22664 | - |
| 20 | 816 | ICESpn529IQ | Streptococcus pneumoniae Spn529 | - |
| 21 | 817 | ICESpn6BST273 | Streptococcus pneumoniae PMEN22 | - |
| 22 | 818 | ICESpn6BST90 | Streptococcus pneumoniae PMEN2 | - |
| 23 | 819 | ICESpnDCC1524 | Streptococcus pneumoniae DCC1524 | - |
| 24 | 820 | ICESpnDCC1738 | Streptococcus pneumoniae DCC1738 | - |
| 25 | 821 | ICESpnDCC1902 | Streptococcus pneumoniae DCC1902 | - |
| 26 | 822 | ICESpnSPN8332 | Streptococcus pneumoniae SPN8332 | - |
| 27 | 826 | ICESpy005IQ | Streptococcus pyogenes Spy005 | - |
| 28 | 828 | ICESpy029IQ | Streptococcus pyogenes Spy029 | - |
| Data derived from experimental literature | ||||
| Putative ICEs predicted by bioinformatic methods | ||||
| Element | No. of sequences | Download | Alignment |
| Proteins | 1133 | Fasta | Multiple protein sequence alignment by MUSCLE online |
| ICEs | 19 | Fasta | Nucleotide sequence comparison by webACT |
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(1) Morici E et al. (2017). A new mosaic integrative and conjugative element from Streptococcus agalactiae carrying resistance genes for chloramphenicol (catQ) and macrolides [mef(I) and erm(TR)]. J Antimicrob Chemother. 72(1):64-67. [PudMed:27621174]
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(2) Del Grosso M et al. (2016). ICESpy009, a Conjugative Genetic Element Carrying mef(E) in Streptococcus pyogenes. Antimicrob Agents Chemother. 60(7):3906-12. [PudMed:27067338]
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| (3) Mingoia M et al. (2014). Genetic basis of the association of resistance genes mef(I) (macrolides) and catQ (chloramphenicol) in streptococci. Front Microbiol. 0.727083333. [PudMed:25610433] |
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(4) Mingoia M et al. (2014). Tn5253 family integrative and conjugative elements carrying mef(I) and catQ determinants in Streptococcus pneumoniae and Streptococcus pyogenes. Antimicrob Agents Chemother. 58(10):5886-93. [PudMed:25070090]
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(5) Croucher NJ et al. (2014). Variable recombination dynamics during the emergence, transmission and 'disarming' of a multidrug-resistant pneumococcal clone. BMC Biol. 12:49. [PudMed:24957517]
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(6) Croucher NJ et al. (2011). Rapid pneumococcal evolution in response to clinical interventions. Science. 331(6016):430-4. [PudMed:21273480]
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(7) Mingoia M et al. (2011). Heterogeneity of Tn5253-like composite elements in clinical Streptococcus pneumoniae isolates. Antimicrob Agents Chemother. 55(4):1453-9. [PudMed:21263055]
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| (8) Ding F et al. (2009). Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant Streptococcus pneumoniae serotype 14. BMC Genomics. 0.526388889. [PudMed:19361343] |
| (9) Croucher NJ et al. (2009). Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniaeSpain23F ST81. J Bacteriol. 191(5):1480-9. [PudMed:19114491] |
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(10) Henderson-Begg SK et al. (2009). Diversity of putative Tn5253-like elements in Streptococcus pneumoniae. Int J Antimicrob Agents. 33(4):364-7. [PudMed:19097761]
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(11) Srinivas P et al. (2000). Genetic and transcriptional analysis of a regulatory region in streptococcal conjugative transposon Tn5252. Plasmid. 44(3):262-74. [PudMed:11078652]
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(12) Munoz-Najar U et al. (1999). An operon that confers UV resistance by evoking the SOS mutagenic response in streptococcal conjugative transposon Tn5252. J Bacteriol. 181(9):2782-8. [PudMed:10217768]
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(13) Sampath J et al. (1998). Identification of a DNA cytosine methyltransferase gene in conjugative transposon Tn5252. Plasmid. 39(1):63-76. [PudMed:9473447]
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(14) Srinivas P et al. (1997). Site-specific nicking in vitro at ori T by the DNA relaxase of Tn5252. Plasmid. 37(1):42-50. [PudMed:9073581]
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(15) Vijayakumar MN et al. (1995). Genetic organization of streptococcal conjugative transposon Tn5252. Dev Biol Stand. 85:63-9. [PudMed:8586242]
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(16) Vijayakumar MN et al. (1993). Nucleotide sequence analysis of the termini and chromosomal locus involved in site-specific integration of the streptococcal conjugative transposon Tn5252. J Bacteriol. 175(9):2713-9. [PudMed:8386725]
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(17) Kilic AO et al. (1994). Identification and nucleotide sequence analysis of a transfer-related region in the streptococcal conjugative transposon Tn5252. J Bacteriol. 176(16):5145-50. [PudMed:8051031]
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(18) Ayoubi P et al. (1991). Tn5253, the pneumococcal omega (cat tet) BM6001 element, is a composite structure of two conjugative transposons, Tn5251 and Tn5252. J Bacteriol. 173(5):1617-22. [PudMed:1847905]
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| experimental literature |
| in silico analysis literature |