Detailed information of TA system TA099983

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 322763..323433
• Replicon: chromosome
• Accession: NZ_CP027721
• Organism: Pseudomonas chlororaphis subsp. aureofaciens strain ChPhzTR36

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: C4K12_RS01440
• Protein ID: WP_009046452.1
• Coordinates: 322763..323191 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A3G7DZE9
• Locus tag: C4K12_RS01445
• Protein ID: WP_009046453.1
• Coordinates: 323188..323433 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C4K12_RS01410	317987..318496	-	510	WP_009046447.1	DUF1097 domain-containing protein	-
C4K12_RS01415	318530..319270	-	741	WP_009046448.1	SDR family oxidoreductase	-
C4K12_RS01420	319399..320289	+	891	WP_038630364.1	LysR family transcriptional regulator	-
C4K12_RS01425	320414..320596	+	183	WP_009041685.1	type II toxin-antitoxin system HicA family toxin	-
C4K12_RS01430	320626..321027	+	402	WP_009046450.1	type II toxin-antitoxin system HicB family antitoxin	-
C4K12_RS01435	321596..322633	+	1038	WP_124314665.1	L-glyceraldehyde 3-phosphate reductase	-
C4K12_RS01440	322763..323191	-	429	WP_009046452.1	type II toxin-antitoxin system VapC family toxin	Toxin
C4K12_RS01445	323188..323433	-	246	WP_009046453.1	plasmid stabilization protein	Antitoxin
C4K12_RS01450	323573..324412	-	840	WP_009046454.1	taurine dioxygenase	-
C4K12_RS01455	324648..325487	-	840	WP_009046455.1	taurine ABC transporter permease TauC	-
C4K12_RS01460	325484..326278	-	795	WP_028683844.1	taurine ABC transporter ATP-binding subunit	-
C4K12_RS01465	326374..327351	-	978	WP_009046457.1	taurine ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15867.39 Da
• Isoelectric Point: 5.4927

>T99983 WP_009046452.1 NZ_CP027721:c323191-322763 [Pseudomonas chlororaphis subsp. aureofaciens]
MIVLDTNVLSELMRPQPDTAVLLWIEAQPVEDLYISAMTMAEILHGIARLPHGKRKQTLHASALAMFEEDFIDRIVPFGT
QAALYYAHLVSHRERSGQPINLVDAQIAAICRVHDAAIATRNTKDFTDTGLIVINPWLPLEV

Nucleotide

• Length: 429 bp

>T99983 NZ_CP027721:c323191-322763 [Pseudomonas chlororaphis subsp. aureofaciens]
ATGATAGTACTCGACACAAATGTGTTGTCAGAACTGATGCGCCCTCAACCGGATACGGCGGTATTGCTGTGGATCGAAGC
GCAACCCGTCGAAGACCTCTACATCAGCGCCATGACCATGGCCGAGATTCTCCACGGTATCGCGCGCCTGCCCCACGGCA
AGCGCAAACAGACGCTGCATGCATCGGCGCTGGCTATGTTCGAGGAAGACTTCATCGACCGCATCGTGCCCTTCGGAACC
CAAGCGGCTCTTTACTACGCGCATCTGGTCTCGCATCGCGAAAGATCAGGCCAGCCGATCAATCTGGTGGATGCGCAGAT
TGCAGCGATATGCCGGGTCCACGACGCCGCGATCGCCACTCGTAACACCAAGGATTTCACCGACACCGGGCTGATCGTTA
TCAACCCCTGGCTGCCGCTCGAGGTCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9103.27 Da
• Isoelectric Point: 6.2314

>AT99983 WP_009046453.1 NZ_CP027721:c323433-323188 [Pseudomonas chlororaphis subsp. aureofaciens]
MASLTIRNLDDHIKERLRIEAAHNGHSMEEEARLILRRALSRTADSQGLGSRIRARFAETGGVELELPERTEPARLVDLG
E

Nucleotide

• Length: 246 bp

>AT99983 NZ_CP027721:c323433-323188 [Pseudomonas chlororaphis subsp. aureofaciens]
ATGGCCAGCCTTACGATCCGTAATCTGGACGACCACATCAAAGAACGCCTGCGCATCGAGGCCGCTCACAATGGTCATTC
CATGGAAGAAGAAGCCCGATTGATTTTGCGCCGCGCATTGAGCAGGACAGCTGACAGCCAAGGCCTGGGCAGCCGTATCA
GGGCACGCTTTGCCGAGACCGGCGGAGTAGAGCTGGAGCTGCCTGAACGTACCGAACCGGCACGCTTGGTGGACCTGGGC
GAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3G7DZE9