Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2629606..2630225 Replicon chromosome
Accession NZ_CP027706
Organism Pseudomonas sp. CMR12a

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C4K39_RS12370 Protein ID WP_124346520.1
Coordinates 2630043..2630225 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C4K39_RS12365 Protein ID WP_124346519.1
Coordinates 2629606..2630007 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K39_RS12345 2626463..2626894 - 432 WP_124346515.1 carboxymuconolactone decarboxylase family protein -
C4K39_RS12350 2626922..2627542 - 621 WP_124346516.1 NAD(P)H-dependent oxidoreductase -
C4K39_RS12355 2627539..2627985 - 447 WP_124346517.1 GNAT family N-acetyltransferase -
C4K39_RS12360 2628073..2629476 + 1404 WP_124346518.1 PLP-dependent aminotransferase family protein -
C4K39_RS12365 2629606..2630007 - 402 WP_124346519.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C4K39_RS12370 2630043..2630225 - 183 WP_124346520.1 type II toxin-antitoxin system HicA family toxin Toxin
C4K39_RS12375 2630608..2630868 - 261 WP_124346521.1 hypothetical protein -
C4K39_RS12380 2631371..2631652 - 282 WP_124346522.1 hypothetical protein -
C4K39_RS12385 2632250..2634856 + 2607 WP_124346523.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6827.05 Da        Isoelectric Point: 11.6157

>T99892 WP_124346520.1 NZ_CP027706:c2630225-2630043 [Pseudomonas sp. CMR12a]
VQSRQLIKELEAAGWILDRITGSHHLFKHPYRPNTVPVPHPKKDLPRGTVRAIRKLAGLI

Download         Length: 183 bp

>T99892 NZ_CP027706:c2630225-2630043 [Pseudomonas sp. CMR12a]
GTGCAAAGCAGACAGCTAATCAAGGAGCTTGAAGCCGCAGGATGGATACTGGACCGGATAACCGGAAGCCACCATCTGTT
CAAGCATCCTTACAGACCCAACACCGTTCCGGTGCCTCACCCGAAGAAGGACCTGCCACGGGGAACGGTCAGGGCCATCC
GAAAACTGGCCGGACTGATATAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14600.64 Da        Isoelectric Point: 5.1405

>AT99892 WP_124346519.1 NZ_CP027706:c2630007-2629606 [Pseudomonas sp. CMR12a]
MQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFESAYSAAIEIAHVMLEELARAGQAIPLPSPTHKHRVNPDFAGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQQIDRFVREHNIKSRSSFLADAALEKLGR

Download         Length: 402 bp

>AT99892 NZ_CP027706:c2630007-2629606 [Pseudomonas sp. CMR12a]
ATGCAATATCCCATCTGCATCGAATGGGGCGACGAACACACCGCCACCGGCATCCAGATTCCCGACATCCCCGGCGCAGT
CACCGCCGGCGACACCTTCGAGAGCGCCTACAGCGCCGCCATCGAGATCGCCCACGTCATGCTCGAAGAACTGGCCCGCG
CCGGACAAGCCATTCCCCTGCCCTCACCCACCCACAAACACCGCGTCAACCCCGATTTCGCGGGCATGGGCTGGGGCATG
CTGGACATCGACATCACGCCGTACCTGGGCAAGACCGAGAAGGTCAACGTGACGCTGCCAGGTTATGTGATTCAGCAGAT
CGACCGCTTTGTCCGTGAGCACAACATCAAGAGCCGGTCGTCCTTCCTGGCCGATGCCGCGCTGGAAAAGCTCGGGCGCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References