Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 349737..350535 Replicon chromosome
Accession NZ_CP027548
Organism Escherichia coli strain 2014C-3061

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0F3UPG9
Locus tag C6992_RS01790 Protein ID WP_000854698.1
Coordinates 349737..350114 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0F3T7G0
Locus tag C6992_RS01795 Protein ID WP_000017094.1
Coordinates 350161..350535 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6992_RS01775 348116..348958 - 843 WP_061317356.1 DUF4942 domain-containing protein -
C6992_RS01780 349043..349240 - 198 WP_000839251.1 DUF957 domain-containing protein -
C6992_RS01785 349252..349740 - 489 WP_001054226.1 hypothetical protein -
C6992_RS01790 349737..350114 - 378 WP_000854698.1 TA system toxin CbtA family protein Toxin
C6992_RS01795 350161..350535 - 375 WP_000017094.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C6992_RS01800 350610..350831 - 222 WP_001220316.1 DUF987 domain-containing protein -
C6992_RS01805 350900..351376 - 477 WP_001186714.1 RadC family protein -
C6992_RS01810 351392..351877 - 486 WP_000213709.1 antirestriction protein -
C6992_RS01815 351969..352787 - 819 WP_001234402.1 DUF945 domain-containing protein -
C6992_RS29405 352868..353079 + 212 Protein_338 hypothetical protein -
C6992_RS29020 353198..353653 - 456 Protein_339 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13975.94 Da        Isoelectric Point: 7.9087

>T99334 WP_000854698.1 NZ_CP027548:c350114-349737 [Escherichia coli]
MKTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRSHYRTVNDITLGKRTEAKR

Download         Length: 378 bp

>T99334 NZ_CP027548:c350114-349737 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CCACTACAGAACGGTAAATGACATTACCCTGGGTAAACGCACGGAGGCAAAACGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13732.42 Da        Isoelectric Point: 5.4488

>AT99334 WP_000017094.1 NZ_CP027548:c350535-350161 [Escherichia coli]
VSGTLHETNYPNDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT99334 NZ_CP027548:c350535-350161 [Escherichia coli]
GTGTCAGGCACACTCCATGAGACAAATTATCCCAACGACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAATTACATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F3UPG9

Antitoxin

Source ID Structure
AlphaFold DB A0A0F3T7G0

References