Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3486236..3487034 Replicon chromosome
Accession NZ_CP027544
Organism Escherichia coli strain 2013C-3264

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0F3UPG9
Locus tag MJ68_RS19065 Protein ID WP_000854698.1
Coordinates 3486236..3486613 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0F3T7G0
Locus tag MJ68_RS19070 Protein ID WP_000017094.1
Coordinates 3486660..3487034 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ68_RS19040 3482328..3483866 - 1539 WP_001187182.1 lysine decarboxylation/transport transcriptional activator CadC -
MJ68_RS19050 3484615..3485457 - 843 WP_001280439.1 DUF4942 domain-containing protein -
MJ68_RS19055 3485542..3485739 - 198 WP_000839251.1 DUF957 domain-containing protein -
MJ68_RS19060 3485751..3486239 - 489 WP_001054226.1 hypothetical protein -
MJ68_RS19065 3486236..3486613 - 378 WP_000854698.1 TA system toxin CbtA family protein Toxin
MJ68_RS19070 3486660..3487034 - 375 WP_000017094.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MJ68_RS19075 3487109..3487330 - 222 WP_001220316.1 DUF987 domain-containing protein -
MJ68_RS19080 3487399..3487875 - 477 WP_001443324.1 RadC family protein -
MJ68_RS19085 3487890..3488375 - 486 WP_000213700.1 antirestriction protein -
MJ68_RS19090 3488466..3488906 - 441 Protein_3449 DUF932 domain-containing protein -
MJ68_RS19095 3489025..3490185 - 1161 Protein_3450 reverse transcriptase -
MJ68_RS19100 3490730..3491110 - 381 Protein_3451 DUF932 domain-containing protein -
MJ68_RS19110 3491265..3491423 - 159 WP_001369071.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13975.94 Da        Isoelectric Point: 7.9087

>T99286 WP_000854698.1 NZ_CP027544:c3486613-3486236 [Escherichia coli]
MKTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRSHYRTVNDITLGKRTEAKR

Download         Length: 378 bp

>T99286 NZ_CP027544:c3486613-3486236 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CCACTACAGAACGGTAAATGACATTACCCTGGGTAAACGCACGGAGGCAAAACGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13732.42 Da        Isoelectric Point: 5.4488

>AT99286 WP_000017094.1 NZ_CP027544:c3487034-3486660 [Escherichia coli]
VSGTLHETNYPNDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT99286 NZ_CP027544:c3487034-3486660 [Escherichia coli]
GTGTCAGGCACACTCCATGAGACAAATTATCCCAACGACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAATTACATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F3UPG9

Antitoxin

Source ID Structure
AlphaFold DB A0A0F3T7G0

References