Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-AbrB
Location 3912474..3913026 Replicon chromosome
Accession NZ_CP027527
Organism Magnetospirillum gryphiswaldense strain R3/S1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MSR1L_RS18465 Protein ID WP_106003476.1
Coordinates 3912688..3913026 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MSR1L_RS18460 Protein ID WP_106003475.1
Coordinates 3912474..3912698 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MSR1L_RS18440 3908472..3909071 - 600 WP_106003471.1 hypothetical protein -
MSR1L_RS18445 3909058..3909687 - 630 WP_106003472.1 glycoside hydrolase family 19 protein -
MSR1L_RS18450 3909697..3912000 - 2304 WP_106003473.1 phage tail protein -
MSR1L_RS18455 3911997..3912422 - 426 WP_106003474.1 C40 family peptidase -
MSR1L_RS18460 3912474..3912698 + 225 WP_106003475.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MSR1L_RS18465 3912688..3913026 + 339 WP_106003476.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MSR1L_RS18470 3913023..3913547 - 525 WP_106003477.1 DUF1833 family protein -
MSR1L_RS18475 3913540..3913890 - 351 WP_068490551.1 hypothetical protein -
MSR1L_RS18480 3913920..3914357 - 438 WP_106003478.1 hypothetical protein -
MSR1L_RS18485 3914360..3915703 - 1344 WP_106003479.1 hypothetical protein -
MSR1L_RS18490 3915706..3916272 - 567 WP_106003480.1 hypothetical protein -
MSR1L_RS18495 3916277..3916687 - 411 WP_106003481.1 hypothetical protein -
MSR1L_RS18500 3916698..3917567 - 870 WP_106003482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3888718..3952175 63457


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-108)

Antitoxin

SpoVT-AbrB domain

(6-37)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12406.44 Da        Isoelectric Point: 7.8960

>T99164 WP_106003476.1 NZ_CP027527:3912688-3913026 [Magnetospirillum gryphiswaldense]
VDFKPFEIVVVPFPFTDKVGAKRRPALIVSTSAFNRSHDQAVLAMITTAQQSDWPSDVHLEEWSAAGLSTACRVRLKLFT
LDRELILRRVGTLAPHDMMAVQTALSQCIAVV

Download         Length: 339 bp

>T99164 NZ_CP027527:3912688-3913026 [Magnetospirillum gryphiswaldense]
GTGGACTTTAAGCCGTTCGAAATCGTGGTCGTGCCATTCCCGTTCACGGACAAGGTCGGCGCGAAGCGGCGTCCAGCCCT
GATCGTTTCGACATCGGCGTTCAATCGCAGCCATGATCAAGCCGTGCTGGCCATGATCACGACGGCCCAACAGAGCGACT
GGCCCAGCGATGTCCACCTTGAAGAATGGAGTGCCGCTGGCCTATCCACCGCATGTCGGGTTCGGCTGAAGTTGTTCACA
CTTGATCGAGAGCTGATTCTCAGGCGGGTGGGAACCTTGGCTCCGCACGACATGATGGCTGTCCAGACGGCTCTGTCGCA
GTGCATCGCCGTCGTCTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8273.37 Da        Isoelectric Point: 4.7672

>AT99164 WP_106003475.1 NZ_CP027527:3912474-3912698 [Magnetospirillum gryphiswaldense]
MELARITAKGQMTIPKKVRDSAHLSAGDLVAFVVEDDRVQFRKVMPGGDEYLRAVQGTLGEWNSPEDEEAWRGL

Download         Length: 225 bp

>AT99164 NZ_CP027527:3912474-3912698 [Magnetospirillum gryphiswaldense]
ATGGAACTCGCTCGCATCACGGCGAAAGGGCAGATGACGATCCCGAAGAAGGTGCGTGATTCCGCCCACCTATCGGCAGG
GGACTTGGTTGCCTTCGTTGTTGAGGATGACCGTGTCCAATTCCGCAAAGTCATGCCCGGTGGTGACGAATACCTGCGGG
CCGTCCAGGGGACGCTCGGCGAATGGAACAGTCCCGAGGACGAGGAGGCGTGGCGTGGACTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References