Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 4447323..4447849 | Replicon | chromosome |
| Accession | NZ_CP027457 | ||
| Organism | Escherichia coli strain 88-3493 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | C6W79_RS22495 | Protein ID | WP_000323025.1 |
| Coordinates | 4447323..4447610 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | C6W79_RS22500 | Protein ID | WP_000534858.1 |
| Coordinates | 4447610..4447849 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C6W79_RS22455 | 4442347..4442562 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| C6W79_RS26750 | 4442782..4442952 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| C6W79_RS22460 | 4443316..4443531 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| C6W79_RS22465 | 4443832..4444044 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| C6W79_RS26430 | 4444099..4444188 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| C6W79_RS22470 | 4444466..4445218 | - | 753 | WP_001047135.1 | antitermination protein | - |
| C6W79_RS22475 | 4445232..4446281 | - | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| C6W79_RS22480 | 4446283..4446561 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| C6W79_RS22485 | 4446628..4446879 | - | 252 | WP_000980994.1 | hypothetical protein | - |
| C6W79_RS22490 | 4447096..4447251 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| C6W79_RS22495 | 4447323..4447610 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| C6W79_RS22500 | 4447610..4447849 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| C6W79_RS22505 | 4447874..4448179 | + | 306 | WP_001326990.1 | hypothetical protein | - |
| C6W79_RS22510 | 4448382..4448714 | + | 333 | WP_001301033.1 | protein FlxA | - |
| C6W79_RS22520 | 4449151..4450464 | - | 1314 | WP_000589005.1 | ISNCY family transposase | - |
| C6W79_RS26605 | 4451233..4451520 | - | 288 | Protein_4122 | hypothetical protein | - |
| C6W79_RS22535 | 4451742..4452146 | + | 405 | WP_000839179.1 | IS66 family insertion sequence hypothetical protein | - |
| C6W79_RS22540 | 4452143..4452490 | + | 348 | WP_000612626.1 | IS66 family insertion sequence element accessory protein TnpB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4404939..4467465 | 62526 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T99007 WP_000323025.1 NZ_CP027457:c4447610-4447323 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T99007 NZ_CP027457:c4447610-4447323 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT99007 WP_000534858.1 NZ_CP027457:c4447849-4447610 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT99007 NZ_CP027457:c4447849-4447610 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|