Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2939764..2940562 | Replicon | chromosome |
| Accession | NZ_CP027449 | ||
| Organism | Escherichia coli strain 2014C-3097 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | C6W73_RS15160 | Protein ID | WP_000854902.1 |
| Coordinates | 2939764..2940141 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A093DMQ4 |
| Locus tag | C6W73_RS15165 | Protein ID | WP_001280952.1 |
| Coordinates | 2940188..2940562 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C6W73_RS15130 | 2935110..2936087 | + | 978 | WP_000633220.1 | type II secretion system minor pseudopilin GspK | - |
| C6W73_RS15135 | 2936084..2937262 | + | 1179 | WP_000094974.1 | type II secretion system protein GspL | - |
| C6W73_RS15140 | 2937264..2937800 | + | 537 | WP_000942795.1 | GspM family type II secretion system protein YghD | - |
| C6W73_RS15145 | 2938143..2938985 | - | 843 | WP_001280537.1 | DUF4942 domain-containing protein | - |
| C6W73_RS15150 | 2939070..2939267 | - | 198 | WP_000839249.1 | DUF957 domain-containing protein | - |
| C6W73_RS15155 | 2939279..2939767 | - | 489 | WP_000779175.1 | hypothetical protein | - |
| C6W73_RS15160 | 2939764..2940141 | - | 378 | WP_000854902.1 | TA system toxin CbtA family protein | Toxin |
| C6W73_RS15165 | 2940188..2940562 | - | 375 | WP_001280952.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| C6W73_RS15170 | 2940725..2940946 | - | 222 | WP_000692311.1 | DUF987 domain-containing protein | - |
| C6W73_RS15175 | 2941009..2941485 | - | 477 | WP_001186726.1 | RadC family protein | - |
| C6W73_RS15180 | 2941501..2941986 | - | 486 | WP_001562321.1 | antirestriction protein | - |
| C6W73_RS15185 | 2942041..2942859 | - | 819 | WP_001234620.1 | DUF945 domain-containing protein | - |
| C6W73_RS15195 | 2942959..2943192 | - | 234 | WP_106879165.1 | DUF905 family protein | - |
| C6W73_RS15200 | 2943271..2943726 | - | 456 | WP_032186189.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM | 2852639..2985917 | 133278 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14307.29 Da Isoelectric Point: 7.2922
>T98907 WP_000854902.1 NZ_CP027449:c2940141-2939764 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
NACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
NACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T98907 NZ_CP027449:c2940141-2939764 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AATGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AATGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13719.50 Da Isoelectric Point: 6.6249
>AT98907 WP_001280952.1 NZ_CP027449:c2940562-2940188 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS
Download Length: 375 bp
>AT98907 NZ_CP027449:c2940562-2940188 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGGCACAGGCACCCGCAACCACCTCATAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGGCACAGGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|